Abstract: The present invention provides unique methodologies for inducing new bone apposition in-vivo generally or at a localized site and for therapeutically treating a subject afflicted with a pathological disorder of bone which is characterized by a deficiency of calcium ions in the bone matrix. The methodology for treating generalized defective skeletile mineralization comprises administering sufficient quantities of .alpha..sub.2 HS-glycoprotein to the subject such that the concentration of this naturally occurring plasma protein is not substantially less than about 600 micrograms per milliliter of serum in-vivo. Alternatively, the method for treatment of localized defective skeletile mineralization comprises administration of a therapeutic admixture containing about 300 mircograms of .alpha..sub.2 HS-glycoprotein per gram of filler material to the site of skeletal defect.

Abstract: A device for clasping hair comprises a comb member that includes a base portion having a facing surface and a plurality of teeth extending in spaced, generally mutually parallel relation from the base portion. A clasp member having a clasp surface includes a loop for embracing at least one of the teeth of the comb member in sliding relation to thereby mount the clasp member on the comb member with the facing and clasping surfaces in tightly confronting relation. At least one of the facing and the clasping surfaces is contoured to diverge from the other of the surfaces and define a region having a generally V-shaped cross-section therebetween when in confronting relation.