Patents by Inventor Craig E. Caufield

Craig E. Caufield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapamycin oximes
    Patent number: 5023264
    Abstract: A derivative of rapamycin in which the 27-position has the structure ##STR1## wherein R.sup.1 is hydrogen, alkyl, or --CH.sub.2 Ar;Ar is ##STR2## wherein R.sup.2, R.sup.3, and R.sup.4 are each, independently, hydrogen, alkyl, aralkyl, alkoxy, hydroxy, cyano, halo, nitro, carbalkoxy, trifluoromethyl, amino, or a carboxylic acid;X is N, O, or S;or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppresive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: June 11, 1991
    Assignee: American Home Products Corporation
    Inventors: Craig E. Caufield, Amedeo A. Failli
  • Hydrogenated rapamycin derivatives
    Patent number: 5023262
    Abstract: A derivative of rapamycin where one, two, or three of the double bonds at the 1-,3-, or 5-positions of rapamycin have been reduced to the corresponding alkane, or a pharmaceutically acceptable salt thereof, which by virtue of its antifungal activity is useful in treating fungal infections.
    Type: Grant
    Filed: August 14, 1990
    Date of Patent: June 11, 1991
    Assignee: American Home Products Corporation
    Inventors: Craig E. Caufield, John H. Musser, James M. Rinker