Abstract: A method and apparatus for noninvasive and real-time monitoring and feedback control of the extent and geometry of tissue damage induced by various thermal modalities (laser, electromagnetic wave, ultrasound and thermistor) in different thermal therapies (hyperthermia, thermal coagulation and ablation) is provided. Unlike the existing ultrasound configurations, which use non-Doppler ultrasound techniques, the single-beam configuration in this invention employs a multiple-range-gate pulsed Doppler technique. The configuration may be operated in A-mode, M-mode, or multi-dimensional image mode to monitor tissue thermal response in the tissue being treated at multiple tissue depths along the sound beam. By measuring changes in phase (i.e., motion) and amplitude (i.e., echogenicity) of the echoes returned from the tissue under treatment, the Doppler system can determine temporal and spatial profiles of tissue temperature and the extent and geometry of tissue thermal damage.

Abstract: An epicardial multifunctional probe has been designed to measure blood flow velocity and muscle thickening with two sensors. The probe is implantable and remains inside the patient after surgery. The probe is removable through a small opening in the patient's chest.

Abstract: This invention is an implantable, extractable probe for biological sensors which has a stable attachment to different sizes of vessels or organs and is safety and easily removed from the patient. The body of the probe is made up of a biocompatible flexible material. The probe encircles the vessel or organ to be monitored by suture attachment of the probe body to itself. A release wire within the probe body holds the suture in place until time for the removal of the probe from the body. The probe is then extracted without a surgical procedure.

Abstract: A novel method and device for performing percutaneous transluminal angioplasty to treat occlusive artery disease is disclosed. The method involves simultaneous measurement and display of the fluid pressure and volume existing within the balloon catheter as the procedure is performed. Information is produced which is useful in determining the efficacy of the procedure as it is performed which obviates the need for arbitrary repeated inflations. The information is also useful in the subsequent management of the patient's disease.