Abstract: Provided herein are methods and reagents for increasing chemosensitivity to chemotherapy and immunotherapy in cancer patients. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an DKK3-neutralizing agent, such as a DKK3-neutralizing antibody provided herein. The methods can further include administering an effective amount of chemotherapy or immunotherapy to said patient.

Abstract: An archery sight device for selectively illuminating fiber optic range markers calibrated to a specific distance, a selector switch and a range indicator display for accurately aiming and releasing an arrow at a designated target. The sight device comprises a housing that attaches between the upper and lower limb of an archery bow, and provides a sight window with a plurality of fiber optic pins with illuminating tips. A selective pin or set of pins is illuminated at a time, corresponding to a distance indicated by a digital display for the user to reference. A selector switch extending from the device and attached to the bow allows the user to cycle through pre-calibrated distances for a specific bow, while a range finder device may be incorporated to accurately measure the distance to a target and adjust the display and chosen illuminated pin as required.

Abstract: An archery sight device for selectively illuminating fiber optic range markers calibrated to a specific distance, a selector switch and a range indicator display for accurately aiming and releasing an arrow at a designated target. The sight device comprises a housing that attaches between the upper and lower limb of an archery bow, and provides a sight window with a plurality of fiber optic pins with illuminating tips. A selective pin or set of pins is illuminated at a time, corresponding to a distance indicated by a digital display for the user to reference. A selector switch extending from the device and attached to the bow allows the user to cycle through pre-calibrated distances for a specific bow, while a range finder device may be incorporated to accurately measure the distance to a target and adjust the display and chosen illuminated pin as required.

Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with pancreatic cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of pancreatic cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.