Patents by Inventor Craig M. Stolen
Craig M. Stolen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11666749Abstract: An implantable antibacterial barrier device for an elongated medical device, the elongated medical device configured to extend from a first site, through a second site, to a third site. The implantable antibacterial barrier device includes a housing configured to be disposed at the first site, a working electrode configured to be disposed at the second site, and a reference electrode configured to be disposed at the first site. The housing includes barrier circuitry. The working electrode electrically is coupled to the barrier circuitry. The reference electrode is electrically coupled to the barrier circuitry. The barrier circuitry is configured to selectively maintain the working electrode at a negative electrical potential relative to the reference electrode to form an antibacterial barrier.Type: GrantFiled: October 21, 2020Date of Patent: June 6, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Jeffrey E. Stahmann, Keith R. Maile, Danielle Frankson, Craig M. Stolen, David J. Ternes
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Publication number: 20210121683Abstract: An implantable antibacterial barrier device for an elongated medical device, the elongated medical device configured to extend from a first site, through a second site, to a third site. The implantable antibacterial barrier device includes a housing configured to be disposed at the first site, a working electrode configured to be disposed at the second site, and a reference electrode configured to be disposed at the first site. The housing includes barrier circuitry. The working electrode electrically is coupled to the barrier circuitry. The reference electrode is electrically coupled to the barrier circuitry. The barrier circuitry is configured to selectively maintain the working electrode at a negative electrical potential relative to the reference electrode to form an antibacterial barrier.Type: ApplicationFiled: October 21, 2020Publication date: April 29, 2021Inventors: Jeffrey E. Stahmann, Keith R. Maile, Danielle Frankson, Craig M. Stolen, David J. Ternes
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Patent number: 10905883Abstract: Methods and systems for selecting electrical stimulation parameters for an electrical stimulation device implanted in a patient can use an iterative process for identifying electrodes for stimulation, as well as suitable stimulation parameters. The process begins with an initial set of electrode combinations to identify regions of the nerve or other tissue for stimulation. This leads to selection of other electrode combinations to test, followed by the selection of multiple electrode groups (which can include three or more electrodes) for stimulation.Type: GrantFiled: December 1, 2017Date of Patent: February 2, 2021Assignee: BOSTON SCIENTIFIC NEUROMODULATION CORPORATIONInventors: Bryan Allen Clark, William Conrad Stoffregen, Michael X. Govea, Craig M. Stolen, David J. Ternes, David Blum, Pramodsingh Hirasingh Thakur, Stephen B. Ruble
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Patent number: 10773077Abstract: A device for producing a trabecular fiber within a ventricle of a heart. The device includes a substrate and a first tissue anchor connected to the substrate. The substrate is formed of a non-rigid material.Type: GrantFiled: September 22, 2017Date of Patent: September 15, 2020Assignee: Boston Scientific Scimed IncInventors: Thomas J. Herbst, Craig M. Stolen, Candace A. Rhodes
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Patent number: 10751375Abstract: Embodiments herein include methods for enhancing post-ischemic functional recovery through administration of mitochondria and related devices and methods. In an embodiment, a method for enhancing post-ischemic functional recovery is included. The method can include harvesting somatic cells from a patient or a donor, converting the somatic cells into induced pluripotent stem cells, extracting mitochondria from the induced pluripotent stem cells, and transplanting the mitochondria into the patient. Other embodiments are also included herein.Type: GrantFiled: September 25, 2017Date of Patent: August 25, 2020Assignee: Boston Scientific Scimed, Inc.Inventors: Craig M. Stolen, Allan Charles Shuros
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Patent number: 10502747Abstract: Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data with respect to medical devices and methods, amongst other things. In an embodiment, the disclosure can include a method of predicting the likelihood of response to CRT therapy. The method can include quantifying levels of one or more biomarkers in a biological sample of a patient, analyzing the quantified levels to determine response to CRT therapy, wherein a panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein.Type: GrantFiled: January 31, 2013Date of Patent: December 10, 2019Assignees: Cardiac Pacemakers, Inc., MUSC Foundation for Research DevelopmentInventors: Craig M. Stolen, Timothy E. Meyer, Milan Seth, Francis G. Spinale, Nicholas David Wold
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Publication number: 20180368765Abstract: The present disclosure relates generally to systems and methods for detecting and monitoring the exercise pressor reflex. In some embodiments, a medical system includes a first sensor connected to a user, wherein the first sensor detects an exertion metric of the user, and a second sensor connected to the user, wherein the second sensor detects a blood pressure metric of the user. The medical system may further include a processing component in communication with the first and second sensors, wherein the processing component is capable of processing the exertion metric and the blood pressure metric to determine an elevated blood pressure metric of the user based on a comparison between a baseline blood pressure metric and the detected blood pressure metric. The processing component may further determine an exercise pressor reflex (EPR) metric based on a comparison between the elevated blood pressure metric and the exertion metric.Type: ApplicationFiled: June 26, 2018Publication date: December 27, 2018Inventors: Kyle H. Srivastava, Craig M. Stolen, Bryan A. Clark, Pramodsingh H. Thakur
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Publication number: 20180154156Abstract: Methods and systems for selecting electrical stimulation parameters for an electrical stimulation device implanted in a patient can use an iterative process for identifying electrodes for stimulation, as well as suitable stimulation parameters. The process begins with an initial set of electrode combinations to identify regions of the nerve or other tissue for stimulation. This leads to selection of other electrode combinations to test, followed by the selection of multiple electrode groups (which can include three or more electrodes) for stimulation.Type: ApplicationFiled: December 1, 2017Publication date: June 7, 2018Inventors: Bryan Allen Clark, William Conrad Stoffregen, Michael X. Govea, Craig M. Stolen, David J. Ternes, David Blum, Pramodsingh Hirasingh Thakur, Stephen B. Ruble
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Publication number: 20180147409Abstract: A device for producing a trabecular fiber within a ventricle of a heart. The device includes a substrate and a first tissue anchor connected to the substrate. The substrate is formed of a non-rigid material.Type: ApplicationFiled: September 22, 2017Publication date: May 31, 2018Inventors: Thomas J. Herbst, Craig M. Stolen, Candace A. Rhodes
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Publication number: 20180085407Abstract: Embodiments herein include methods for enhancing post-ischemic functional recovery through administration of mitochondria and related devices and methods. In an embodiment, a method for enhancing post-ischemic functional recovery is included. The method can include harvesting somatic cells from a patient or a donor, converting the somatic cells into induced pluripotent stem cells, extracting mitochondria from the induced pluripotent stem cells, and transplanting the mitochondria into the patient. Other embodiments are also included herein.Type: ApplicationFiled: September 25, 2017Publication date: March 29, 2018Inventors: Craig M. Stolen, Allan Charles Shuros
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Publication number: 20170326358Abstract: An implantable lead including a lead body, an electrode coupled to the lead body, and at least one cellular modulation segment. The lead body has a proximal end and a distal end. The lead body includes an outer layer defining a lumen. The outer layer has an outside surface. The electrical conductor is disposed within the lumen of the outer layer. The electrode is coupled to the lead body. The electrode is in electrical communication with the electrical conductor. The at least one cellular modulation segment is on the outside surface of the outer layer. The at least one cellular modulation segment includes topographic surface features configured to modulate cellular responses. The topographic surface features include a plurality of raised nodes and a plurality of raised ridges interconnecting the plurality of nodes and forming a lattice structure.Type: ApplicationFiled: August 2, 2017Publication date: November 16, 2017Inventors: Craig M. Stolen, Mark Schwartz, John Foley, Lili Liu
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Patent number: 9744348Abstract: Embodiments of the invention are related to leads with topographic surface features and related methods, amongst other things. In an embodiment, the invention includes an implantable lead including a lead body having a proximal end and a distal end, the lead body including an outer layer defining a lumen, the lead body further including a first electrical conductor disposed within the lumen of the outer layer. The implantable lead can further include a first electrode coupled to the lead body, the electrode in electrical communication with the first electrical conductor. The implantable lead can also include a cellular modulation segment on the external surface of the lead body, the cellular modulation segment comprising topographic surface features configured to modulate cellular responses. Other embodiments are also included herein.Type: GrantFiled: August 21, 2007Date of Patent: August 29, 2017Assignee: CARDIAC PACEMAKERS, INC.Inventors: Craig M. Stolen, Mark J. Schwartz, John D. Foley, Lili Liu
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Patent number: 9227071Abstract: Embodiments of the invention are related to systems and methods for setting parameters of implantable medical devices, amongst other things. In an embodiment, the invention includes a method for programming an implantable medical device including sensing concentrations of a predictive marker such as ET-1 in a patient, selecting programming parameter values based on the sensed concentrations of the predictive marker, and implementing the selected programming parameter values. In an embodiment the invention includes a method for detecting arrhythmia in a patient including sensing concentrations of the predictive marker in a patient, selecting a level of stringency to be used in an arrhythmia detection module based on the sensed concentrations of the predictive marker, sensing electrical signals in the patient, and evaluating the sensed electrical signals for indicia of an arrhythmia using the arrhythmia detection module. Other embodiments are also included herein.Type: GrantFiled: June 28, 2012Date of Patent: January 5, 2016Assignee: Cardiac Pacemakers, Inc.Inventors: Craig M. Stolen, Harlan Bos, Timothy E. Meyer, Arjun Sharma
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Publication number: 20130237439Abstract: Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data with respect to medical devices and methods, amongst other things. In an embodiment, the disclosure can include a method of predicting the likelihood of response to CRT therapy. The method can include quantifying levels of one or more biomarkers in a biological sample of a patient, analyzing the quantified levels to determine response to CRT therapy, wherein a panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein.Type: ApplicationFiled: January 31, 2013Publication date: September 12, 2013Applicants: MEDICAL UNIVERSITY OF SOUTH CAROLINA, CARDIAC PACEMAKERS, INC.Inventors: Craig M. Stolen, Timothy E. Meyer, Milan Seth, Francis G. Spinale, Nicholas David Wold
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Publication number: 20130196870Abstract: Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data and related medical devices and methods, amongst other things. An embodiment can include a method of screening patients. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include analyzing the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. In an embodiment, the disclosure can include a method of diagnosing a patient. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include diagnosing the patient based at least in part on the quantified levels.Type: ApplicationFiled: January 31, 2013Publication date: August 1, 2013Applicants: MEDICAL UNIVERSITY OF SOUTH CAROLINA, CARDIAC PACMAKERS, INC.Inventors: Craig M. Stolen, Timothy E. Meyer, Milan Seth, Francis G. Spinale, Nicholas David Wold
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Publication number: 20130046196Abstract: Embodiments of the invention are related to systems and methods for setting parameters of implantable medical devices, amongst other things. In an embodiment, the invention includes a method for programming an implantable medical device including sensing concentrations of a predictive marker such as ET-1 in a patient, selecting programming parameter values based on the sensed concentrations of the predictive marker, and implementing the selected programming parameter values. In an embodiment the invention includes a method for detecting arrhythmia in a patient including sensing concentrations of the predictive marker in a patient, selecting a level of stringency to be used in an arrhythmia detection module based on the sensed concentrations of the predictive marker, sensing electrical signals in the patient, and evaluating the sensed electrical signals for indicia of an arrhythmia using the arrhythmia detection module. Other embodiments are also included herein.Type: ApplicationFiled: June 28, 2012Publication date: February 21, 2013Applicant: CARDIAC PACEMAKERS, INC.Inventors: Craig M. Stolen, Harlan Bos, Timothy E. Meyer, Arjun Sharma
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Publication number: 20090054960Abstract: Embodiments of the invention are related to leads with topographic surface features and related methods, amongst other things. In an embodiment, the invention includes an implantable lead including a lead body having a proximal end and a distal end, the lead body including an outer layer defining a lumen, the lead body further including a first electrical conductor disposed within the lumen of the outer layer. The implantable lead can further include a first electrode coupled to the lead body, the electrode in electrical communication with the first electrical conductor. The implantable lead can also include a cellular modulation segment on the external surface of the lead body, the cellular modulation segment comprising topographic surface features configured to modulate cellular responses. Other embodiments are also included herein.Type: ApplicationFiled: August 21, 2007Publication date: February 26, 2009Applicant: Cardiac Pacemakers, Inc.Inventors: Craig M. Stolen, Mark J. Schwartz, John D. Foley, Lili Liu