Abstract: One example method for biomarker detection in digitized pathology samples includes receiving a plurality of image patches corresponding to an image of a pathology slide having a hematoxylin and eosin-stained (“H&E”) stained sample of tissue, each image patch representing a different portion of the image; for each image patch, determining, using a first trained machine learning (“ML”) model, a patch biomarker status; and determining, using a second trained ML model, a tissue sample biomarker status for the sample of tissue based on the patch biomarker statuses of the image patches.

Abstract: One example method includes obtaining one or more histopathology images of a sample from a cancer patient; selecting a plurality of tissue image patches from the one or more histopathology images; determining, by a deep learning system comprising a plurality of trained machine learning (ML) models, a plurality of image features for the plurality of tissue image patch, wherein each tissue image patch is analyzed by one of the trained ML models; determining, by the deep learning system, probabilities of patient survival based on the determined plurality of image features; and generating, by the deep learning system, a prediction of patient survival based on the determined probabilities.

Abstract: One example method includes receiving a digital image of a needle core prostate biopsy, displaying, using a display device, a magnified portion of the digital image, obtaining, from a deep learning model, Gleason scores corresponding to patches of the magnified portion of the digital image, and displaying, using the display device, a superimposed overlay on the magnified portion of the digital image based on the Gleason scores and corresponding confidence values of the Gleason scores, the superimposed overlay comprising one or more outlines corresponding one or more Gleason scores associated with the magnified portion of the digital image and comprising image patches having colors based on a Gleason score of the Gleason scores corresponding to an underlying portion of the magnified portion of the digital image and a confidence value of the corresponding Gleason score.

Abstract: Systems and methods of analyzing a user's motion during a swimming session are described. One or more motions sensors can collect motion data of the user. A processor circuit can make motion analysis based on the motion data. The processor circuit can determine if the user's arm swing is a genuine swim stroke. The processor circuit can also determine whether the user is swimming or turning. The processor circuit can also classify the user's swim stroke style. The processor circuit can also determine the user's swim stroke phase. The processor circuit can also determine the user's stroke orbit consistency.

Abstract: One example method for AI prediction of prostate cancer outcomes involves receiving an image of prostate tissue; assigning Gleason pattern values to one or more regions within the image using an artificial intelligence Gleason grading model, the model trained to identify Gleason patterns on a patch-by-patch basis in a prostate tissue image; determining relative areal proportions of the Gleason patterns within the image; assigning at least one of a risk score or risk group value to the image based on the determined relative areal proportions; and outputting at least one of the risk score or the risk group value.

Abstract: Systems and methods are disclosed for tracking physiological states and parameters for calorie estimation. A start of an exercise session associated with a user of a wearable computing device is determined. Heart rate data is measured for a first period of time. An onset heart rate value of the user is determined based on the measured heart rate data, the onset heart rate value associated with a lowest valid heart rate measured during the first period of time. A resting heart rate parameter (RHR) of a calorimetry model is associated with at least one of the onset heart rate value, a preset RHR, and an RHR based on user biometric data. Energy expenditure of the user during a second period of time is estimated based on the calorimetry model and a plurality of heart rate measurements obtained by the wearable computing device during the second period of time.

Abstract: Systems and methods are disclosed for tracking physiological states and parameters for calorie estimation. A start of an exercise session associated with a user of a wearable computing device is determined. Heart rate data is measured for a first period of time. An onset heart rate value of the user is determined based on the measured heart rate data, the onset heart rate value associated with a lowest valid heart rate measured during the first period of time. A resting heart rate parameter (RHR) of a calorimetry model is associated with at least one of the onset heart rate value, a preset RHR, and an RHR based on user biometric data. Energy expenditure of the user during a second period of time is estimated based on the calorimetry model and a plurality of heart rate measurements obtained by the wearable computing device during the second period of time.

Abstract: A set of methods is described for identifying optimal repetition rates for certain repetitive processes, and identifying musical selections with tempi matched to those optimal rates, so as to use synchrony with musical rhythms as a guide to optimizing performance in repetitive physical, biomechanical, and physiologic processes.

Abstract: A method of estimating the maximal oxygen uptake of an individual on the basis of heart rate data, biometric data, biomechanical data, and geophysical data is described. These data can be collected as the individual engages in activities requiring various levels of exertion, without modifying those activities from the ordinary manner in which they are performed. In particular, in some embodiments the method described here obviates the conventional need for a laboratory setting when estimating maximal oxygen uptake and the method can be applied to estimate maximal oxygen uptake under more natural conditions than conventional testing protocols requiring treadmills or stationary ergometers typically permit. Furthermore, it is described how such estimates of maximal oxygen uptake can be used to estimate other quantities of interest, including fat and carbohydrate metabolism, lactate production, and water and electrolyte loss during exercise.