Abstract: The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

Abstract: The invention relates to &ggr;-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.

Abstract: The invention relates to linear &ggr;-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

Abstract: The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

Abstract: The present invention is relates to a method for purifying a &ggr;-carboxylase from Conus snails and to a method for assaying the activity of this &ggr;-glutamyl carboxylase.

Abstract: A memory controller apparatus for controlling access to a memory array from a microprocessor and a plurality of devices is described. The memory controller apparatus interfaces the microprocessor and the plurality of devices. The microprocessor functions asynchronously with the plurality of devices. The memory controller apparatus comprises a delay line circuitry coupled to receive a selected request for accessing the memory array from one of the microprocessor and the plurality of devices, the delay line means further including means for generating a plurality of memory timing control signals. The memory timing control signals are used for accessing the memory array. The delay line circuitry functions independently of any clock signal. The delay line circuitry is only triggered by the selected request. The memory controller apparatus further comprises a memory state circuitry coupled to the delay line circuitry for controlling sequence and timing of the memory timing control signals.