Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: A slope sensitive pitch adjustor for a bicycle seat includes a rotatable seat support, a gravity sensor mounted thereto, a means for rotating the rotatable seat support, and an automated controller configured to drive the rotating means in response to an acceleration signal received from the gravity sensor. The automated controller stores data representing an initial condition of a pitch angle of the rotatable seat support with respect to horizontal and executes a control algorithm to maintain the initial condition when the bicycle is ridden over changing gradients.

Abstract: A cell site test tool provides field technicians with resources to support multiple aspects of cell site testing. The cell site test tool includes multiple, integrated and removably connectable modules such as a base module, a user interface module, and a battery module. Additional modules include a CPRI module to provide Common Public Radio Interface testing, an OTDR module to provide dedicated Optical Time-Domain Reflectometer testing, a CAA module to provide Cable Antenna Analysis testing, a fiber inspection module to visually inspect optical fiber, and an SA/CPRI module to provide Radio Frequency over Common Public Radio Interface testing.

Abstract: A cell site test tool provides field technicians with resources to support multiple aspects of cell site testing. The cell site test tool includes multiple, integrated and removably connectable modules such as a base module, a user interface module, and a battery module. Additional modules include a CPRI module to provide Common Public Radio Interface testing, an OTDR module to provide dedicated Optical Time-Domain Reflectometer testing, a CAA module to provide Cable Antenna Analysis testing, a fiber inspection module to visually inspect optical fiber, and an SA/CPRI module to provide Radio Frequency over Common Public Radio Interface testing.

Abstract: A system may identify, by a first service, one or more faulted data links associated with a network device of the datacenter and update, by a second service, a configuration of the network device to remove data traffic from the identified one or more faulted data links based on a redundancy threshold associated with the network device. The system may also generate a repair ticket message associated with the identified one or more faulted data links and transmit test traffic across the identified one or more faulted data links while monitoring for a repair ticket resolution message associated with repairing the identified one or more faulted data links.

Abstract: A plunger, a needle assembly and a retractable syringe comprising same are provided. The plunger comprises a plunger member and a plunger outer having a lock spring that prevents or impedes movement of the plunger member after needle retraction. The plunger further comprises another locking member for engaging the barrel to prevent or impede further movement of the plunger outer after delivery of fluid contents. The plunger member has a plunger seal which engages a retractable needle of the needle assembly for retraction. The retractable needle comprises a cannula and needle body with a plurality of fluid channels that co-operate with a fluid conduit of the plunger seal to efficiently direct fluid to the cannula. A needle retainer comprises a plurality of barbed arms releasably coupled to the needle body, whereby an ejector with tabs facilitates release of the retractable needle from the needle retainer to allow compressed spring-driven retraction.

Abstract: A cache coherent system includes a directory with more than one snoop filter, each of which stores information in a different set of snoop filter entries. Each snoop filter is associated with a subset of all caching agents within the system. Each snoop filter uses an algorithm chosen for best performance on the caching agents associated with the snoop filter. The number of snoop filter entries in each snoop filter is primarily chosen based on the caching capacity of just the caching agents associated with the snoop filter. The type of information stored in each snoop filter entry of each snoop filter is chosen to meet the desired filtering function of the specific snoop filter.

Abstract: A modular test instrument for performing tests and measurements in a network is disclosed. The modular test instrument may include a modular processing unit comprising a processor and memory, the modular processing unit connectable to at least one modular test unit or modular test subunit. The modular test instrument may also include a modular display unit connectable to the modular processing unit or the modular test unit. Display modularity may enable quick and cost-efficient display replacement when damage, malfunction, or failure is incurred. Furthermore, the modular test instrument may include an additional modular test subunit connectable to at least one of the modular processing unit or the modular test unit.

Abstract: A system may identify, by a first service, one or more faulted data links associated with a network device of the datacenter and update, by a second service, a configuration of the network device to remove data traffic from the identified one or more faulted data links based on a redundancy threshold associated with the network device. The system may also generate a repair ticket message associated with the identified one or more faulted data links and transmit test traffic across the identified one or more faulted data links while monitoring for a repair ticket resolution message associated with repairing the identified one or more faulted data links.

Abstract: Disclosed is a dual squeegee apparatus that may be sold to fuel station chains to replace the previous single squeegee designs, and thus offer patrons the ability to clean exterior automotive mirrors, lights and smaller windows in addition to the rest of the windows. This may enable fuel station chains to benefit from offering a competitive advantage to their customers to ideally secure more fuel sales and customer attention. This idea has very important benefits: It allows customers to clean the exterior of their vehicles mirrors, lights and smaller windows in addition to the rest of the windows. Never previously offered by any fuel station chains, and by facilitating extra customer service for the purchasing fuel station chains, this may in turn secure more sales and suggests increased profits.

Abstract: There is described a water purifying apparatus comprising: (i) at least one water inlet; (ii) an ultra-violet (UVC) radiation chamber connected to the water inlet(s); (iii) a plurality of UVC light emitting diodes (UVC-LEDs) for the emission of UVC light into the radiation chamber; (iv) a control to operate UVC-LEDs in use, and (v) at least one UVC-LED aging monitor to provide feedback to the control.

Abstract: A method for protecting software from tampering includes steps for processing, using a computer, first compiled software stored in a computer memory to generate a cryptographic key, the first compiled software configured to perform software protection functions and defined second functions distinct from the software protection functions when executed by a computer processor, the cryptographic key consisting of a first portion of the first compiled software comprising executable code compiled from the software protection functions, encrypting a second portion of the first compiled software using the cryptographic key to produce second compiled software comprising the first portion in unencrypted form and the second portion encrypted with the cryptographic key, wherein the second portion comprises executable code compiled from the defined second functions, and storing the second compiled software in a computer memory for distribution to a client device.

Abstract: A cache coherent system includes a directory with more than one snoop filter, each of which stores information in a different set of snoop filter entries. Each snoop filter is associated with a subset of all caching agents within the system. Each snoop filter uses an algorithm chosen for best performance on the caching agents associated with the snoop filter. The number of snoop filter entries in each snoop filter is primarily chosen based on the caching capacity of just the caching agents associated with the snoop filter. The type of information stored in each snoop filter entry of each snoop filter is chosen to meet the desired filtering function of the specific snoop filter.

Abstract: A replaceable needle assembly is provided for a retractable, prefilled syringe comprising a barrel having a mounting member and a plunger, whereby the retractable needle can be replaced by a user without affecting the retraction mechanism. The replaceable needle assembly comprises a needle fitted to a retractable needle mount and a needle retainer. The needle mount is removably, screw-threadedly mountable to the mounting member of the barrel. The needle retainer comprises a plurality of fingers that releasably engage the retractable needle to thereby prevent inadvertent retraction of the retractable needle before engagement by the plunger. The plunger comprises a plunger seal comprising an outer member and an inner member that engages the needle for spring-driven retraction. At the end of retraction, a lock is formed between the plunger and barrel to prevent re-use of the syringe.

Abstract: A resealable wet or dry application roller container, with optional disposable insert liner, for the sealed storage and transportation of a wet or dry application roller, either by itself, or while remaining attached to the application roller frame, and after rolling off any excess paint from a wet application roller, and being sealed within container, with, or without, optional disposable insert liner, does not leak regardless of orientation.

Abstract: Methods and systems are provided for diagnosing a shock absorber coupled to a vehicle tire. In one example, a sensor of a tire pressure measurement system coupled inside a tire is used to measure a tire pressure as well as an oscillatory behavior of the tire. A state of health of a shock absorber coupled to the tire is estimated based on the oscillatory behavior.

Abstract: A cache coherent system includes a directory with more than one snoop filter, each of which stores information in a different set of snoop filter entries. Each snoop filter is associated with a subset of all caching agents within the system. Each snoop filter uses an algorithm chosen for best performance on the caching agents associated with the snoop filter. The number of snoop filter entries in each snoop filter is primarily chosen based on the caching capacity of just the caching agents associated with the snoop filter. The type of information stored in each snoop filter entry of each snoop filter is chosen to meet the desired filtering function of the specific snoop filter.

Abstract: The present invention is directed to genome editing systems, reagents and methods for the treatment of hemoglobinopathies.

Abstract: A resealable wet or dry application roller container, with optional disposable insert liner, for the sealed storage and transportation of a wet or dry application roller, either by itself, or while remaining attached to the application roller frame, and after rolling off any excess paint from a wet application roller, and being sealed within container, with, or without, optional disposable insert liner, does not leak regardless of orientation.