Abstract: A system suitable for delivering a therapeutic agent to a target site may include a container for holding a therapeutic agent; a pressure source having pressurized fluid, the pressure source in selective fluid communication with at least a portion of the container; a catheter in selective fluid communication with the container and configured for delivery of the therapeutic agent or the pressurized fluid to a target site; and a housing configured to securely retain the container and movably support a switch, where the switch is movable between a first position and a second position, where when the switch is in the first position, delivery of the therapeutic agent is prevented while delivery of the pressurized fluid is permitted, and where when the switch is in the second position, delivery of the therapeutic agent is permitted.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent and a distal constraining arrangement is engaged with a distal end of the stent, the distal constraining arrangement including a first distal constraining member engaged with a first distal portion of the stent and a second distal constraining member engaged with a second distal portion of the stent. When the stent is in the first configuration, the proximal restraining assembly and the distal restraining assembly applies an axial mechanical force to the distal constraining member.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A release wire is disposed through the elongate shaft and releasably engaged with portion of the proximal constraining arrangement and the distal constraining arrangement member. A handle assembly is operably connected to the proximal constraining arrangement and the distal constraining arrangement, the handle assembly comprising a brake assembly. The proximal arrangement and the distal arrangement are coupled to the brake of the handle.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A sheath is positioned longitudinally around the inner elongate shaft, the elongate shaft extending coaxially at least partially within the lumen of the sheath is also included. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A handle assembly comprising an axially moveable outer shuttle, a first inner shuttle operably connected to the proximal constraining arrangement and a second inner shuttle operably connected to the distal constraining arrangement and outer sheath.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A sheath is positioned longitudinally around the inner elongate shaft, the inner elongate shaft extending coaxially at least partially within the lumen of the outer sheath, the outer sheath moveably positionable relative to the outer elongate shaft. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A handle assembly is connected to the proximal constraining arrangement, the distal constraining arrangement, and the outer sheath. A brake assembly is positioned within the handle assembly.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. The stent delivery system includes a handle assembly comprising a first shuttle operably connected to the proximal constraining arrangement and a second shuttle operably connected to the distal constraining arrangement. A brake assembly positioned is within the handle assembly, the proximal constraining arrangement being coupled to a portion of the brake assembly.

Abstract: A stent delivery system includes an inner elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. An outer elongate shaft including a proximal portion, a distal portion, and first, second, and third lumens. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. The first proximal constraining member is positioned within the first lumen of the outer elongate shaft, the second proximal constraining member is positioned within the second lumen of the outer elongate shaft, and the distal constraining arrangement is positioned within the inner elongate shaft.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A release wire is disposed through the elongate shaft and releasably engaged with portion of the proximal constraining arrangement and the distal constraining arrangement member. A handle assembly comprising a shuttle and a spring arrangement is positioned therein. A first brake assembly is disposed within the handle assembly and a second brake assembly is disposed within the handle assembly proximal to the first brake assembly.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A sheath is positioned longitudinally around the inner elongate shaft, the inner elongate shaft extending coaxially at least partially within the lumen of the outer sheath, the outer sheath moveably positionable relative to the outer elongate shaft. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A handle assembly is connected to the proximal constraining arrangement, the distal constraining arrangement, and the outer sheath. A brake assembly is positioned within the handle assembly.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. The stent delivery system includes a handle assembly comprising a first shuttle operably connected to the proximal constraining arrangement and a second shuttle operably connected to the distal constraining arrangement. A brake assembly positioned is within the handle assembly, the proximal constraining arrangement being coupled to a portion of the brake assembly.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A release wire is disposed through the elongate shaft and releasably engaged with portion of the proximal constraining arrangement and the distal constraining arrangement member. A handle assembly comprising a shuttle and a spring arrangement is positioned therein. A first brake assembly is disposed within the handle assembly and a second brake assembly is disposed within the handle assembly proximal to the first brake assembly.

Abstract: A stent delivery system includes an inner elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. An outer elongate shaft including a proximal portion, a distal portion, and first, second, and third lumens. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. The first proximal constraining member is positioned within the first lumen of the outer elongate shaft, the second proximal constraining member is positioned within the second lumen of the outer elongate shaft, and the distal constraining arrangement is positioned within the inner elongate shaft.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent and a distal constraining arrangement is engaged with a distal end of the stent, the distal constraining arrangement including a first distal constraining member engaged with a first distal portion of the stent and a second distal constraining member engaged with a second distal portion of the stent. When the stent is in the first configuration, the proximal restraining assembly and the distal restraining assembly applies an axial mechanical force to the distal constraining member.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A sheath is positioned longitudinally around the inner elongate shaft, the elongate shaft extending coaxially at least partially within the lumen of the sheath is also included. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A handle assembly comprising an axially moveable outer shuttle, a first inner shuttle operably connected to the proximal constraining arrangement and a second inner shuttle operably connected to the distal constraining arrangement and outer sheath.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent. A distal constraining arrangement is engaged with a distal end of the stent. A release wire is disposed through the elongate shaft and releasably engaged with portion of the proximal constraining arrangement and the distal constraining arrangement member. A handle assembly is operably connected to the proximal constraining arrangement and the distal constraining arrangement, the handle assembly comprising a brake assembly. The proximal arrangement and the distal arrangement are coupled to the brake of the handle.