Patents by Inventor Cristal I. Gama

Cristal I. Gama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chondroitin sulfate binding proteins and modulators thereof
    Patent number: 8623610
    Abstract: Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further, compounds that modulate the activity of chondroitin sulfate binding proteins can be identified. For example, TNF-? was found to bind specifically to CS-E and CS-E can be used to modulate the interaction of TNF-? with the TNF receptor.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: January 7, 2014
    Assignee: California Institute of Technology
    Inventors: Cristal I. Gama, Sarah E. Tully, Linda C. Hsieh-Wilson
  • Small molecule stimulators of neuronal growth
    Patent number: 8338387
    Abstract: Provided herein are small molecule stimulators of neuronal growth, their preparation, and their use for treatment of neurological disorders. In one embodiment, provided herein are methods of treatment, prevention, or amelioration of a variety of medical conditions associated with neurological disorders using the compounds and compositions provided herein.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: December 25, 2012
    Assignee: California Institute of Technology
    Inventors: Linda C. Hsieh-Wilson, Sarah E. Tully, Ross Mabon, Cristal I. Gama
  • Methods of inducing neuronal growth by a Fucose-?(1-2) galactose (fuc-?(1-2) gal) moiety and a lectin
    Patent number: 7858578
    Abstract: Fucose galactose carbohydrates have been shown to induce neuronal outgrowth. The invention includes methods of inducing neuronal outgrowth using carbohydrates, assemblies, and polymers bearing fucose-galactose moieties, as well as associated proteins. Cell growth can be stimulated in cells in culture or in cells within an animal or patient. Growth stimulation has application to understanding and treatment of neurodegenerative diseases including, for example, Parkinson's disease, Alzheimer's disease and multiple sclerosis and conditions such as stroke, brain injury and spinal cord injury. Such compounds, polymers, and assemblies also can be used to increase neural stem or progenitor cells in culture or in an animal, and to enervate engineered tissue.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: December 28, 2010
    Assignee: California Institute of Technology
    Inventors: Stacey Kalovidouris, Cristal I. Gama, Linda C. Hsieh-Wilson
  • SMALL MOLECULE STIMULATORS OF NEURONAL GROWTH
    Publication number: 20100075920
    Abstract: Provided herein are small molecule stimulators of neuronal growth, their preparation, and their use for treatment of neurological disorders. In one embodiment, provided herein are methods of treatment, prevention, or amelioration of a variety of medical conditions associated with neurological disorders using the compounds and compositions provided herein.
    Type: Application
    Filed: July 29, 2009
    Publication date: March 25, 2010
    Inventors: Linda C. Hsieh-Wilson, Sarah E. Tully, Ross Mabon, Cristal I. Gama
  • Small molecule stimulators of neuronal growth
    Patent number: 7638503
    Abstract: Provided herein are small molecule stimulators of neuronal growth, their preparation, and their use for treatment of neurological disorders. In one embodiment, provided herein are methods of treatment, prevention, or amelioration of a variety of medical conditions associated with neurological disorders using the compounds and compositions provided herein.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: December 29, 2009
    Assignee: California Institute of Technology
    Inventors: Linda C. Hsieh-Wilson, Sarah E. Tully, Ross Mabon, Cristal I. Gama