Patents by Inventor Cristina Crescenzi

Cristina Crescenzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing sertraline hydrochloride polymorphs
    Patent number: 7189876
    Abstract: This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: March 13, 2007
    Assignee: Recordati Industria Chimica e Farmaceutica S.p.A.
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Sertraline hydrochloride form II and methods for the preparation thereof
    Patent number: 7173153
    Abstract: This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 6, 2007
    Assignee: Recordati Industria Chimica E. Farmaceutica S.p.A.
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Sertraline hydrochloride form II and methods for the preparation thereof
    Publication number: 20050032906
    Abstract: This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II.
    Type: Application
    Filed: July 14, 2004
    Publication date: February 10, 2005
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Methods for preparing sertraline hydrochloride polymorphs
    Publication number: 20050032907
    Abstract: This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, denominated form I, II and V, and methods for their preparation.
    Type: Application
    Filed: July 14, 2004
    Publication date: February 10, 2005
    Inventors: Fausto Bonifacio, Cristina Crescenzi, Maria Donnarumma, Dimitri Ippoliti
  • Industrial process for the production of L-carnitine
    Patent number: 6566552
    Abstract: The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative thus obtained is reacted with trimethylamine, obtaining crude L-carnitine, which is then finally purified. The catalyst used for the reduction is a complex of ruthenium bound to a penta-atomic bis-heteroaromatic system. The reduction reaction, performed in controlled conditions of hydrogen pressure, substrate concentration, temperature, and substrate: catalyst molar ratio, enables 4-chloro-3-hydoxybutyrate or 4-chloro-hydroxybutyamide to be obtained in a high yield. The process described, which leads to L-carnitine being obtained, is easily applicable on an industrial scale.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: May 20, 2003
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Maria Ornella Tinti, Oreste Piccolo, Fausto Bonifacio, Cristina Crescenzi, Sergio Penco
  • Industrial process for the production of L-carnitine
    Publication number: 20020165408
    Abstract: The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative thus obtained is reacted with trimethylamine, obtaining crude L-carnitine, which is then finally purified. The catalyst used for the reduction is a complex of ruthenium bound to a penta-atomic bis-heteroaromatic system. The reduction reaction, performed in controlled conditions of hydrogen pressure, substrate concentration, temperature, and substrate: catalyst molar ratio, enables 4-chloro-3-hydoxybutyrate or 4-chloro-hydroxybutyamide to be obtained in a high yield. The process described, which leads to L-carnitine being obtained, is easily applicable on an industrial scale.
    Type: Application
    Filed: May 7, 2001
    Publication date: November 7, 2002
    Inventors: Maria Ornella Tinti, Oreste Piccolo, Fausto Bonifacio, Cristina Crescenzi, Sergio Penco