Patents by Inventor Cuiping Chen

Cuiping Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of selecting nonsedating H1-antagonists
    Publication number: 20030144336
    Abstract: A method is described in accordance with which one may select a nonsedating histamine H1-antagonist; comprising the step of determining whether a candidate H1-antagonist is a substrate for P-gp, especially P-gp expressed by MDR1 or mdr1a/1b, comprising the step of determining the brain-to-plasma AUC ratio in mdr1a/1b KO mice, and in WT mice, and selecting said candidate where the brain-to-plasma AUC ratio for said KO mice to the brain-to-plasma concentration ratio for said WT mice is 1.5 or greater.
    Type: Application
    Filed: May 30, 2002
    Publication date: July 31, 2003
    Applicant: Pfizer Inc.
    Inventors: Cuiping Chen, Jae S. Lee, John W. Watson
  • Method of screening candidate compounds for susceptibility to oxidative metabolism
    Publication number: 20020058295
    Abstract: A method of screening a candidate compound for susceptibility to metabolism by a selected enzyme. The method includes the steps of reacting the candidate compound, an indicator compound precursor and the selected enzyme, the enzyme characterized as having a side reaction associated with metabolic activity of the enzyme wherein a chemical species capable of reacting with the indicator compound precursor is produced; and detecting an indicator compound, the indicator compound produced from the indicator compound precursor by reaction with the chemical species produced from the side reaction associated with metabolic activity of the enzyme, the detection of the indicator compound indicating the susceptibility of the candidate compound to metabolism by the enzyme. A preferred example of the selected enzyme is a cytochrome P450 (CYP).
    Type: Application
    Filed: November 5, 2001
    Publication date: May 16, 2002
    Inventors: Dhiren R. Thakker, Cuiping Chen
  • Method of screening candidate compounds for susceptibility to oxidative metabolism
    Patent number: 6312917
    Abstract: A method of screening a candidate compound for susceptibility to metabolism by a selected enzyme. The method includes the steps of reacting the candidate compound, an indicator compound precursor and the selected enzyme, the enzyme characterized as having a side reaction associated with metabolic activity of the enzyme wherein a chemical species capable of reacting with the indicator compound precursor is produced; and detecting an indicator compound, the indicator compound produced from the indicator compound precursor by reaction with the chemical species produced from the side reaction associated with metabolic activity of the enzyme, the detection of the indicator compound indicating the susceptibility of the candidate compound to metabolism by the enzyme. A preferred example of the selected enzyme is a cytochrome P450 (CYP).
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: November 6, 2001
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Dhiren R. Thakker, Cuiping Chen