Patents by Inventor Curtis Huttenhower

Curtis Huttenhower has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for screening and identifying clinically aggressive prostate cancer
    Patent number: 11971411
    Abstract: The present invention provides methods for screening and diagnosing prostate cancer based on a correlation between cancer cell growth, cancer lethality or recurrence and the expression level of ZFP36 or NEDD9 and PTEN in conjunction with ZFP36. The disclosure also provides methods for screening and diagnosing prostate cancer based on a correlation between cancer lethality and the genotype of rs1910301 SNP. Also provided are methods for treating prostate cancer comprising providing a treatment or monitoring based on the expression level of ZFP36, the expression level of NEDD9, and the expression level of ZFP36 in conjunction with PTEN levels or the genotype of rs1910301 SNP.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: April 30, 2024
    Assignees: DANA-FARBER CANCER INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Curtis Huttenhower, Travis Gerke, Christopher Sweeney, Lorelei Mucci, Gwo-Sho Mary Lee, Daniela Bornigen, Xiaodong Wang, Svitlana Tyekucheva, Kristina Jordahl
  • Methods of treating and diagnosing IBD associated with r. gnavus and/or r. gnavus group IBD colonization
    Patent number: 11806372
    Abstract: This application provides for methods of treatment for IBD, especially in subjects who have R. gnavus species or R. gnavus group IBD strains as a component of their microbiome. The application also provides for methods of diagnosing IBD, as well as kits for use in the claimed methods.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: November 7, 2023
    Assignees: The Broad Institute, Inc., The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Andrew Brantley Hall, Ramnik Xavier, Curtis Huttenhower, Moran Yassour, Hera Vlamakis
  • METHODS OF TREATING AND DIAGNOSING IBD ASSOCIATED WITH R. GNAVUS AND/OR R. GNAVUS GROUP IBD COLONIZATION
    Publication number: 20200155617
    Abstract: This application provides for methods of treatment for IBD, especially in subjects who have R. gnavus species or R. gnavus group IBD strains as a component of their microbiome. The application also provides for methods of diagnosing IBD, as well as kits for use in the claimed methods.
    Type: Application
    Filed: April 20, 2018
    Publication date: May 21, 2020
    Applicants: The Broad Institute, Inc., The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Andrew Brantley Hall, Ramnik Xavier, Curtis Huttenhower, Moran Yassour, Hera Vlamakis
  • COMPOSITIONS AND METHODS FOR SCREENING AND IDENTIFYING CLINICALLY AGGRESSIVE PROSTATE CANCER
    Publication number: 20200041515
    Abstract: The present invention provides methods for screening and diagnosing prostate cancer based on a correlation between cancer cell growth, cancer lethality or recurrence and the expression level of ZFP36 or NEDD9 and PTEN in conjunction with ZFP36. The disclosure also provides methods for screening and diagnosing prostate cancer based on a correlation between cancer lethality and the genotype of rs1910301 SNP. Also provided are methods for treating prostate cancer comprising providing a treatment or monitoring based on the expression level of ZFP36, the expression level of NEDD9, and the expression level of ZFP36 in conjunction with PTEN levels or the genotype of rs1910301 SNP.
    Type: Application
    Filed: January 20, 2017
    Publication date: February 6, 2020
    Inventors: CURTIS HUTTENHOWER, TRAVIS GERKE, CHRISTOPHER SWEENEY, LORELEI MUCCI, GWO-SHO MARY LEE, DANIELA BORNIGEN, XIAODONG WANG, SVITLANA TYEKUCHEVA, KRISTINA JORDAHL
  • PREVOTELLA COPRI AND ENHANCED SUSCEPTIBILITY TO ARTHRITIS
    Publication number: 20160186261
    Abstract: Methods, reagents and compositions thereof for predicting risk for NORA onset in susceptible individuals, diagnosing NORA onset, and/or evaluating efficacy of a therapeutic regimen for treating RA are described herein. Determining the amount of at least one of SEQ ID NOs: 1-19 and/or at least one of a KO presented in either of Tables S4 or S5 serves as a biomarker for the above indications.
    Type: Application
    Filed: November 4, 2014
    Publication date: June 30, 2016
    Inventors: Jose U. Scher, Andrew Sczesnak, Randy S. Longman, Nicola Segata, Carles Ubeda, Eric G. Pamer, Steven B. Abramson, Curtis Huttenhower, Dan R. Littman, Hannah Fehlner-Peach
  • Statistical classifiers for spoken language understanding and command/control scenarios
    Publication number: 20040148170
    Abstract: The present invention involves using one or more statistical classifiers in order to perform task classification on natural language inputs. In another embodiment, the statistical classifiers can be used in conjunction with a rule-based classifier to perform task classification. In one application, a statistical classifier is used in order ascertain if an input is a search query or a natural-language input.
    Type: Application
    Filed: May 30, 2003
    Publication date: July 29, 2004
    Inventors: Alejandro Acero, Ciprian Chelba, YeYi Wang, Leon Wong, Ravi Shahani, Michael Calcagno, Domenic Cipollone, Curtis Huttenhower