Patents by Inventor Curtis Keith

Curtis Keith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations of drugs for the treatment of neoplasms
    Publication number: 20070099905
    Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
    Type: Application
    Filed: October 24, 2006
    Publication date: May 3, 2007
    Inventors: Alexis Borisy, Curtis Keith, Michael Foley, Brent Stockwell, Debra Gaw, M. Nichols, Margaret Lee
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20070010502
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 11, 2007
    Applicant: CombinatoRx Inc.
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmermann, Edward Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael Foley, Michael Slavonic, Brendan Smith, Benjamin Auspitz
  • Compounds and uses thereof
    Publication number: 20060281722
    Abstract: The invention features charge-modified antidepressants and compounds conjugated to either a charged group or a bulky group in a manner that resists in vivo cleavage. The invention provides a method for treating a patient having an inflammatory disease by administering to the patient a compound of the invention.
    Type: Application
    Filed: February 13, 2006
    Publication date: December 14, 2006
    Inventors: Michael Foley, Curtis Keith, Ronald Borchardt
  • Combinations of drugs for the treatment of neoplastic disorders
    Patent number: 7148216
    Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: December 12, 2006
    Assignee: CombinatoRx, Inc.
    Inventors: Alexis Borisy, Curtis Keith, Michael A. Foley, Brent R. Stockwell
  • Combinations for the treatment of immunoinflammatory disorders
    Publication number: 20060234991
    Abstract: The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
    Type: Application
    Filed: February 15, 2006
    Publication date: October 19, 2006
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmermann, Edward Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael Foley
  • Methods for identifying drug combinations for the treatment of proliferative diseases
    Publication number: 20060177864
    Abstract: The invention features methods for identifying new combination therapies for the treatment of cancer and other proliferative diseases.
    Type: Application
    Filed: March 15, 2006
    Publication date: August 10, 2006
    Inventors: M. Nichols, Margaret Lee, Curtis Keith, Yanzhen Zhang
  • Combinations for the treatment of rheumatoid arithritis
    Publication number: 20060148770
    Abstract: The invention features a method for treating a patient diagnosed with rheumatoid arthitis by systemically administering an azole and a steroid to the patient. The invention also features a pharmaceutical composition containing an azole and a steroid for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: June 5, 2003
    Publication date: July 6, 2006
    Inventors: Jason Fong, Edward Jost-Price, Curtis Keith, Palaniyandi Manivasakam, Grant Zimmermann, Robyn Sackeyfio, Grant Zimmermann
  • Combinations for the treatment of inflammatory skin disorders
    Publication number: 20060100181
    Abstract: The invention features methods and compositions for the treatment of inflammatory skin conditions.
    Type: Application
    Filed: May 2, 2003
    Publication date: May 11, 2006
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Grant Zimmermann, Jason Fong, Nicole Hurst, Benjamin Auspitz, M Nichols, Curtis Keith
  • Methods and reagents for the treatment of metabolic disorders
    Publication number: 20060069161
    Abstract: The invention features compositions, methods, and kits for the treatment of metabolic disorders such as diabetes and obesity.
    Type: Application
    Filed: June 30, 2005
    Publication date: March 30, 2006
    Applicant: CombinatoRx, Inc.
    Inventors: Margaret Lee, Grant Zimmermann, Alyce Finelli, Daniel Grau, Curtis Keith, M. Nichols
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050271661
    Abstract: The invention involves the treatment, prevention, and reduction of immunoinflammatory disorders involving the combination of an agent that increases the signal activity of a glucocorticoid receptor (e.g., glucocorticoid receptor agonist) and an agent that modulates the signaling activity of one or more signaling pathways selected from the NF-?B pathway, NFAT pathway, AP-1 pathway, and Elk-1 pathway such that proinflammatory cytokine secretion or production, or any other inflammatory response, is reduced. Further, screening methods are provided for identifying candidate compounds and strategies useful for treating, preventing, or reducing such conditions.
    Type: Application
    Filed: May 16, 2005
    Publication date: December 8, 2005
    Applicant: CombinatoRx, Incorporated
    Inventors: Palaniyandi Manivasakam, Edward Jost-Price, Jane Staunton, Curtis Keith
  • Combinations for the treatment of inflammatory disorders
    Patent number: 6955815
    Abstract: The invention features a pharmaceutical composition that includes amoxapine and a corticosteroid.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: October 18, 2005
    Assignee: CombinatoRx, Incorporated
    Inventors: Robyn Sackeyfio, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy
  • Combinations of drugs for the treatment of neoplastic disorders
    Publication number: 20050192274
    Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
    Type: Application
    Filed: December 28, 2004
    Publication date: September 1, 2005
    Inventors: Alexis Borisy, Curtis Keith, Michael Foley, Brent Stockwell
  • Methods and reagents for the treatment of inflammatory disorders
    Publication number: 20050187200
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: November 12, 2004
    Publication date: August 25, 2005
    Inventors: Benjamin Auspitz, Alexis Borisy, Jason Fong, Nicole Hurst, Edward Jost-Price, Curtis Keith, Palaniyandi Manivasakam, Robyn Sackeyfio, Michael Slavonic, Brendan Smith, Grant Zimmermann
  • Combinations for the treatment of proliferative diseases
    Publication number: 20050158320
    Abstract: The invention features combinations of drugs for the treatment of proliferative diseases (e.g., cancer). The invention also features methods for identifying new combination therapies for the treatment of cancer and other proliferative diseases.
    Type: Application
    Filed: November 9, 2004
    Publication date: July 21, 2005
    Inventors: M. Nichols, Margaret Lee, Curtis Keith, Yanzhen Zhang
  • Combinations for the treatment of immunoinflammatory disorders and proliferative skin diseases
    Publication number: 20050159485
    Abstract: The invention features a method for treating a patient who has an immunoinflammatory disorder or a proliferative skin disease, or is at risk for developing an immunoinflammatory disorder or a proliferative skin disease, by administering to the patient a prostaglandin and a retinoid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammatory or dermal/epidermal proliferation.
    Type: Application
    Filed: January 2, 2003
    Publication date: July 21, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Grant Zimmermann, Nicole Hurst, Jason Fong, Curtis Keith, Alexis Borisy
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20050153947
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 20, 2004
    Publication date: July 14, 2005
    Inventors: Mahesh Padval, Edward Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin Auspitz, M. Nichols, Curtis Keith, Grant Zimmerman, Bradley Brasher, Noah Sachs, Todd Chappell
  • Combinations of drugs for the treatment of neoplasms
    Publication number: 20050137185
    Abstract: The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient chlorpromazine or a chlorpromazine analog and an antiproliferative agent simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
    Type: Application
    Filed: September 17, 2004
    Publication date: June 23, 2005
    Inventors: Margaret Lee, Matthew Nichols, Yanzhen Zhang, Curtis Keith
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050119160
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
    Type: Application
    Filed: October 15, 2004
    Publication date: June 2, 2005
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmermann, Edward Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael Foley, Michael Slavonic, Brendan Smith, Benjamin Auspitz
  • Combinations for the treatment of inflammatory disorders
    Patent number: 6897206
    Abstract: The invention features a method for treating a patient having an inflammatory disorder, by administering to the patient (i) a tricyclic antidepressant (e.g., amoxapine); and (ii) a corticosteroid (e.g., prednisolone) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit inflammation.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: May 24, 2005
    Assignee: CombinatoRx, Inc.
    Inventors: Robyn Sackeyfio, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy
  • Methods for identifying drug combinations for the treatment of proliferative diseases
    Publication number: 20050100508
    Abstract: The invention features methods for identifying new combination therapies for the treatment of cancer and other proliferative diseases.
    Type: Application
    Filed: May 27, 2004
    Publication date: May 12, 2005
    Inventors: M. Nichols, Margaret Lee, Curtis Keith, Yanzhen Zhang