Patents by Inventor Cynthia A. Maryanoff

Cynthia A. Maryanoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 1,5-diaryl-3-substituted pyrazoles
    Patent number: 6953860
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: October 11, 2005
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6890921
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the ?-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: May 10, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Heterocycles useful in the treatment of benign prostatic hyperplasia
    Patent number: 6841682
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the ?-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: January 11, 2005
    Assignee: Janseen Pharmaceutica N.V.
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
  • Process for preparing 1,5-diaryl-3-substituted pyrazoles
    Publication number: 20040230060
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III 1
    Type: Application
    Filed: June 12, 2003
    Publication date: November 18, 2004
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Continuous process for the preparation of fructopyranose sulfamate derivatives
    Publication number: 20040158081
    Abstract: The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) 1
    Type: Application
    Filed: October 23, 2003
    Publication date: August 12, 2004
    Inventors: Thomas W. Adkins, Charles F. Cicco, Penina Feibush, Donald A. Koch, Cynthia Maryanoff, Walter E. Stalzer
  • Novel substituted sulfamate anticonvulsant derivatives
    Publication number: 20040038911
    Abstract: The present invention is directed to novel compounds of the formula (I) 1
    Type: Application
    Filed: May 8, 2003
    Publication date: February 26, 2004
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff, Steven Mehrman, Kirk Sorgi, Frank Villani, Cheryl Kordik, Allen B. Reitz, Bruce Maryanoff
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Publication number: 20030220493
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I 1
    Type: Application
    Filed: June 2, 2003
    Publication date: November 27, 2003
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Novel anticonvulsant derivative salts
    Publication number: 20030176362
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 18, 2003
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Process for preparing 1, 5-diaryl-3-substituted pyrazoles
    Patent number: 6613914
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: September 2, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Synthesis of 3-amino-3-aryl propanoates
    Patent number: 6610855
    Abstract: A process for the synthesis of a compound of the formula wherein R1 is aryl, heteroaryl, substituted aryl or substituted heteroaryl and R2 is hydrogen, alkyl or aralkyl, or salt thereof.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: August 26, 2003
    Assignee: McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Judith H. Cohen, Cynthia A. Maryanoff, Frank John Villani, Jr., Hua M. Zhong
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6593474
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: July 15, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Linda Mulcahy, Xiaobing Li, Allen Reitz, Cynthia Maryanoff, Frank Villani
  • Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
    Patent number: 6576786
    Abstract: The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to a process for purifying the compound of formula (Ia) and novel crystalline forms of the compound of formula (Ia).
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: June 10, 2003
    Assignee: Biocryst Pharmaceuticals Inc.
    Inventors: Ahmed F. Abdel-Magid, Hans-Ulrich Bichsel, Daniel J. Korey, Gunther G. Laufer, Erja A. Lehto, Sebastiano Mattei, Max Rey, Thomas W. Schultz, Cynthia Maryanoff
  • Novel anticonvulsant derivative salts
    Publication number: 20030069190
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 10, 2003
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Process for preparing [S-(R*,S*)]-&bgr;-[[[1-[1-oxo-3(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives
    Patent number: 6515130
    Abstract: A process for preparing a compound of formula I wherein R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl and halogen
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: February 4, 2003
    Inventors: Judith H. Cohen, Michael Justus, Cynthia A. Maryanoff, Armin Rössler, Fridtjof Schröder, Kirk L. Sorgi, Frank J. Villani, Jr., Christian Weh
  • Synthesis of 3-amino-3-aryl propanoates
    Publication number: 20020198400
    Abstract: A process for the synthesis of a compound of the formula 1
    Type: Application
    Filed: July 15, 2002
    Publication date: December 26, 2002
    Inventors: Ahmed F. Abdel-Magid, Judith H. Cohen, Cynthia A. Maryanoff, Frank John Villani, Hua M. Zhong
  • Process for preparing (-)-(1S, 4R) N-protected 4-amino-2-cyclopentene-1-carboxylate esters
    Patent number: 6495711
    Abstract: The invention relates to a process for preparing (−)-(1S,4R) N protected 4-amino-2-cylcopentene-1-carboxylate esters represented by the formula (I) wherein R1 and R2 are as described within the specification.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: December 17, 2002
    Assignee: BioCryst Pharmaceuticals Inc.
    Inventors: Max Rey, Gregor Welti, Cynthia Maryanoff
  • Novel heterocycles useful in the treatment of benign prostatic hyperplasia
    Publication number: 20020165219
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I 1
    Type: Application
    Filed: November 26, 2001
    Publication date: November 7, 2002
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C.F. Yim, Cynthia Maryanoff
  • Process for preparing [S- (R*, S*) ] -beta- [ [ [1- [1-oxo-3- (4-piperidinyl) propyl] -3-piperidinyl] carbonyl]amino] -3-pyridinepropanoic acid and derivatives
    Publication number: 20020137937
    Abstract: A process for preparing a compound of formula I 1
    Type: Application
    Filed: February 22, 2002
    Publication date: September 26, 2002
    Inventors: Judith H. Cohen, Michael Justus, Cynthia A. Maryanoff, Armin Rossler, Fridtjof Harmen Schroder, Kirk L. Sorgi, Frank J. Villani, Christian Weh
  • Process for preparing 1, 5-diaryl-3-substituted pyrazoles
    Publication number: 20020128487
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III 1
    Type: Application
    Filed: March 1, 2002
    Publication date: September 12, 2002
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
    Publication number: 20020061930
    Abstract: The invention relates to a process for preparing substituted cyclopentane derivatives represented by the 1
    Type: Application
    Filed: November 26, 2001
    Publication date: May 23, 2002
    Inventors: Ahmed F. Abdel-Magid, Hans-Ulrich Bichsel, Daniel J. Korey, Gunther G. Laufer, Erja A. Lehto, Sebastiano Mattei, Max Rey, Thomas W. Schultz, Cynthia Maryanoff