Abstract: The disclosure provides for solid products configured for oral use, the products including a carrier material; a releasable material; and wherein the releasable material is combined with the carrier material such that the releasable material is configured for sustained release from the solid product when the solid product is positioned in an oral cavity for a consumer. In another aspect, the disclosure provides for a method of preparing a solid product for oral use, the method comprising providing a releasable material in sprayable form; providing a pouch formed of a fibrous material; and spraying a flavor component onto a least a portion of the pouch one or both of before and after filling the pouch with the oral composition.

Abstract: The disclosure provides for solid products configured for oral use, the products including a carrier material; a releasable material; and wherein the releasable material is combined with the carrier material such that the releasable material is configured for sustained release from the solid product when the solid product is positioned in an oral cavity for a consumer. In another aspect, the disclosure provides for a method of preparing a solid product for oral use, the method comprising providing a releasable material in sprayable form; providing a pouch formed of a fibrous material; and spraying a flavor component onto a least a portion of the pouch one or both of before and after filling the pouch with the oral composition.

Abstract: The present disclosure provides an aerosol delivery device comprising an aerosol source member. In an example embodiment, an aerosol source member of the present disclosure may comprise a substrate portion comprising a nanocellulose material impregnated with an aerosol precursor composition, a heat source configured to heat the aerosol precursor composition from the substrate portion forming an aerosol, and an aerosol pathway extending from the substrate portion to a mouth-end of the aerosol delivery device.

Abstract: The present disclosure provides an aerosol source member and an aerosol delivery device that includes an aerosol source member. The aerosol source member includes a segmented substrate portion that includes a first substrate segment and a second substrate segment. The first substrate segment includes a first aerosol former, the second substrate segment includes a second aerosol former different from the first aerosol former, and the second substrate segment is positioned between the first substrate segment and a downstream end of the aerosol source member. The first substrate segment and the second substrate segment are configured such that when heated by a heat source, the first substrate segment is heated to a first temperature and the second substrate segment is heated to a second temperature that is less than the first temperature.

Abstract: The disclosure provides oral compositions and products formed therewith. Such compositions and products may include a first content of a flavor component having a first release rate and a second content of a flavor component having a second, different release rate. The disclosure further provides methods of preparing compositions and products for oral use. Such methods may include spray-drying a liquid flavor component to form particles of the liquid flavor component and mixing the particles of the liquid flavor component with a long-chain carbohydrate. Such methods also may include combining a content of a first flavor component, a content of a second flavor component, and a filler to form a composition suitable for insertion into an oral cavity. The compositions may be formed such that the first flavor component has a first release profile, and the second flavor component has a second, different release profile.

Abstract: The disclosure provides for solid products configured for oral use, the products including a carrier material; a releasable material; and wherein the releasable material is combined with the carrier material such that the releasable material is configured for sustained release from the solid product when the solid product is positioned in an oral cavity for a consumer. In another aspect, the disclosure provides for a method of preparing a solid product for oral use, the method comprising providing a releasable material in sprayable form; providing a pouch formed of a fibrous material; and spraying a flavor component onto a least a portion of the pouch one or both of before and after filling the pouch with the oral composition.

Abstract: The present disclosure provides an aerosol delivery device comprising an aerosol source member. In an example embodiment, an aerosol source member of the present disclosure may comprise a substrate portion comprising a nanocellulose material impregnated with an aerosol precursor composition, a heat source configured to heat the aerosol precursor composition from the substrate portion forming an aerosol, and an aerosol pathway extending from the substrate portion to a mouth-end of the aerosol delivery device.

Abstract: The present invention relates to a method of making a flavored menthol-containing solid object, which can be used as an input material for hot melt application to a smoking article component. The method generally includes the steps of combining and heating menthol and a flavorant to give a molten mixture; depositing the molten mixture onto a surface; allowing the deposited molten mixture to cool to give a solidified mixture; and removing the solidified mixture from the surface to afford a flavored menthol-containing solid object. The method can further involve melting the solid object and applying the melted material to a smoking article component to modify the flavor/aroma profile of a smoking article into which the coated component is incorporated.

Abstract: The present invention relates to a method of making a flavored menthol-containing solid object, which can be used as an input material for hot melt application to a smoking article component. The method generally includes the steps of combining and heating menthol and a flavorant to give a molten mixture; depositing the molten mixture onto a surface; allowing the deposited molten mixture to cool to give a solidified mixture; and removing the solidified mixture from the surface to afford a flavored menthol-containing solid object. The method can further involve melting the solid object and applying the melted material to a smoking article component to modify the flavor/aroma profile of a smoking article into which the coated component is incorporated.

Abstract: The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue.

Abstract: A smokeless tobacco product configured for insertion into the mouth of a user of the product is provided, the tobacco product including a water-permeable pouch containing a tobacco formulation, the tobacco formulation including a tobacco material and a plurality of microcapsules dispersed within the tobacco material, the plurality of microcapsules including an outer shell encapsulating an internal payload. The internal payload may include an additive such as water, flavorants, binders, colorants, pH adjusters, buffering agents, fillers, disintegration aids, humectants, antioxidants, oral care ingredients, preservatives, additives derived from herbal or botanical sources, and mixtures thereof. Microencapsulated flavorants include tobacco-containing flavorants, such as tobacco extracts or a particulate tobacco material, sweeteners (e.g., sweeteners containing neotame), and vanillin (optionally in a complexed form).

Abstract: Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials include coatings in the form of series of spaced apart bands, each band having a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer. Flavoring agent(s) are included in one or more of the wrapping material itself, a seam adhesive, and/or bands included on the wrapping material.

Abstract: The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue.