Patents by Inventor Czeslaw H. Radziejewski

Czeslaw H. Radziejewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME
    Publication number: 20150071944
    Abstract: The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 12, 2015
    Inventors: Ivan R.S. Correia, Czeslaw H. Radziejewski, Wolfgang Fraunhofer, Nicholas William Warne, Angela Kantor
  • STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME
    Publication number: 20100172862
    Abstract: The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.
    Type: Application
    Filed: November 24, 2009
    Publication date: July 8, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Ivan R. Correia, Czeslaw H. Radziejewski, Wolfgang Fraunhofer, Nicholas W. Warne, Angela Kantor