Abstract: An in vitro chamber for mimicking the mechanical and electrical forces found in vivo under physiological or pathological state. A chamber provides conditioning stimuli. The conditioning stimuli replicate a pathology, including the ability to replicate a diseased pathology. The chamber is configured to allow the additional stimuli to test physical, chemical or electrical stimuli impact on cells experiencing the particular pathology. Pharmaceuticals may be tested ex-vivo on cells exhibiting a pathology in an environment mimicking the in-vitro environment. Physical components such as pacemakers may also be tested on such cells in the chamber.