Patents by Inventor Dagfinn Lovhaug
Dagfinn Lovhaug has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8182790Abstract: A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding affinity for areas of collagen formation, L is a covalent bond, a biomodifier or a linker moiety.Type: GrantFiled: November 21, 2005Date of Patent: May 22, 2012Assignee: GE Healthcare ASInventors: Dagfinn Lovhaug, Morten Eriksen, Hege B. Fjerdingstad, Andrew Healey
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Patent number: 7763234Abstract: A pharmaceutical of the general formula Z—(L)n-V, wherein V denotes an amino acid sequence X1-X2-Val-Tyr-Ile-His-Pro-X8-X9-X10; L denotes a bond or a linker; Z denotes a group that optionally can carry an imaging moiety M; X1 denotes an amino acid; X2 denotes Arg or N-alkylated Arg or a mimetic of Arg; X8, X9 and X10 constitute an ACE cleavage site; Z forms a bond with the amino acid X1 optionally through the linker L; and M where denotes an imageable moiety capable of detection either directly or indirectly in a diagnostic imaging procedure.Type: GrantFiled: March 3, 2005Date of Patent: July 27, 2010Assignee: GE Healthcare ASInventor: Dagfinn Lovhaug
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Publication number: 20090208412Abstract: A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding affinity for areas of collagen formation, L is a covalent bond, a biomodifier or a linker moiety.Type: ApplicationFiled: November 21, 2005Publication date: August 20, 2009Inventors: Dagfinn Lovhaug, Morten Eriksen, Hege B. Fjerdingstad, Andrew Healey
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Patent number: 7431914Abstract: A contrast agent of formula I: V-L-R (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linear or branched amino acid-comprising biomodifier or linker moiety, and R is a reporter moiety detectable in in vivo imaging of a human or animal body.Type: GrantFiled: November 23, 2004Date of Patent: October 7, 2008Assignee: GE Healthcare ASInventors: Alan Cuthbertson, Magne Solbakken, Dagfinn Lovhaug, Philip Duncanson, Harry John Wadsworth, Anthony Eamon Storey, Nigel Anthony Powell
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Publication number: 20070297979Abstract: A pharmaceutical of the general formula Z-(L)n-V, wherein V denotes an amino acid sequence X1—X2-Val-Tyr-Ile-His-Pro-X8—X9—X10; L denotes a bond or a linker; Z denotes a group that optionally can carry an imaging moiety M; X1 denotes an amino acid; X2 denotes Arg or N-alkylated Arg or a mimetic of Arg ; X8, X9 and X10 constitute an ACE cleavage site; Z forms a bond with the amino acid X1 optionally through the linker L; and M where denotes an imageable moiety capable of detection either directly or indirectly in a diagnostic imaging procedure.Type: ApplicationFiled: March 3, 2005Publication date: December 27, 2007Inventor: Dagfinn Lovhaug
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Publication number: 20050002865Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: ApplicationFiled: December 15, 2003Publication date: January 6, 2005Applicant: Amersham Health ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Naevestad, Dagfinn Lovhaug, Halldis Hellebust, Magne Solbakken
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Patent number: 6806045Abstract: A method for the identification and characterization of a receptor in target tissue for which a selected vector has affinity, wherein a transfected cell line expressing the receptor is added to a suspension of encapsulated microbubbles to which the selected vector is coupled and allowing the microbubbles and cells coupled thereto to float to the surface of the suspension. Upon isolating the microbubble-bound cells at the surface, these may be cultured to study the receptor, or cells may be lysed, amplifying the receptor-encoding cDNA and sequencing the cDNA.Type: GrantFiled: January 18, 2002Date of Patent: October 19, 2004Assignee: Amersham Health ASInventors: Mari Ann Kulseth, Dagfinn Lovhaug, Aslak Godal
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Publication number: 20040141922Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: ApplicationFiled: November 26, 2003Publication date: July 22, 2004Applicant: NYCOMED IMAGING ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Anne Naevestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Lovhaug, Magne Solbakken
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Patent number: 6680047Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: GrantFiled: August 10, 2001Date of Patent: January 20, 2004Assignee: Amersham Health ASInventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Nævestad, Dagfinn Løvhaug, Halldis Hellebust, Magne Solbakken
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Publication number: 20030104359Abstract: Separation of target material from a liquid sample is achieved by coupling the target to targetable encapsulated gas microbubbles, allowing the microbubbles and coupled target to float to the surface of the sample to form a floating microbubble/target layer, and separating this layer from the sample. In a positive separation process the microbubbles are then removed from the target, e.g. by bursting. In a negative separation process target-free sample material is recovered following separation of the floating layer. The method may also be used diagnostically to detect the presence of a disease marker in a sample. Novel separation apparatus is also described.Type: ApplicationFiled: November 15, 2002Publication date: June 5, 2003Applicant: NYCOMED IMAGING ASInventors: Alan Cuthbertson, Dagfinn Lovhaug, Hege Fjerdingstad, Pal Rongved, Magne Solbakken, Aslak Godal
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Publication number: 20020106643Abstract: A method for the identification and characterization of a receptor in target tissue for which a selected vector has affinity, wherein a transfected cell line expressing the receptor is added to a suspension of encapsulated microbubbles to which the selected vector is coupled and allowing the microbubbles and cells coupled thereto to float to the surface of the suspension. Upon isolating the microbubble-bound cells at the surface, these may be cultured to study the receptor, or cells may be lysed, amplifying the receptor-encoding cDNA and sequencing the cDNA.Type: ApplicationFiled: January 18, 2002Publication date: August 8, 2002Inventors: Mari Ann Kulseth, Dagfinn Lovhaug, Aslak Godal
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Publication number: 20020102217Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: ApplicationFiled: August 10, 2001Publication date: August 1, 2002Applicant: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Naevestad, Dagfinn Lovhaug, Halldis Hellebust, Magne Solbakken
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Publication number: 20020102215Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilized by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: ApplicationFiled: January 22, 2001Publication date: August 1, 2002Applicant: NYCOMED IMAGING ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Anne Naevestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Lovhaug, Magne Solbakken
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Patent number: 6264917Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: GrantFiled: October 28, 1997Date of Patent: July 24, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pål Rongved, Dagfinn Løvhaug
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Patent number: 6261537Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: GrantFiled: October 29, 1997Date of Patent: July 17, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Anne Nævestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Løvhaug, Magne Solbakken