Abstract: The invention provides improved compositions (e.g., combinations of signal transduction inhibitors) and methods for the prevention, stabilization, or treatment of cancer or other angiogenesis related diseases. In particular, the present methods use combination therapies to modulate the expression or activity of multiple mRNA molecules or proteins associated with angiogenesis or cancer in a mammal (e.g.

Abstract: The present invention pertains to improved methods for the destruction of undesirable tissue using photodynamic therapy (PDT) and/or sonodynamic therapy (SDT). Such methods include the use of fractionated dosing of the photosensitizer or sonosensitizer to ensure that the sensitizer can be found in various compartments of the tissue and appropriate vasculature prior to the application of activating energy such as electromagnetic radiation or ultrasonic energy.

Abstract: The present invention pertains to improved methods for the destruction of undesirable tissue using photodynamic therapy (PDT). Such methods include the use of fractionated dosing of the photosensitizer to ensure that the photosensitizer(s) has sufficient time to enter various compartments of the tissue and appropriate vasculature prior to the application of activating radiation.