Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A method for de-identification of visual media data, including: merging a sequence of images from a set of visual media data into an averaged image; bounding portions of the averaged image that are determined to be relatively fixed, wherein each bounded portion is identified by a corresponding position in the averaged image; generating a template comprising the bounded portions and the corresponding position for each bounded portion in the averaged image; and de-identifying the sequence of images by obfuscating content in the bounded portions.

Abstract: A visual media de-identification system is described. The system includes an image merger and a de-identifying engine. The image merger is configured to merge a sequence of images from a set of visual media data into an averaged image. The de-identifying engine is configured to: bound portions of the averaged image that are determined to be relatively fixed, wherein each bounded portion is identified by a corresponding position in the averaged image; generate a template comprising the bounded portions and the corresponding position for each bounded portion in the averaged image; and de-identify the sequence of images by obfuscating content in the bounded portions.

Abstract: Embodiments of the present invention provide a data transmission method and apparatus. ROHC packets that use a same Context ID are encapsulated into MAC PDU, wherein the MAC PDU is formed by a MAC PDU packet header and a MAC PDU payload. The Context ID of the ROHC packets is carried in the MAC PDU packet header, and the Context ID is not carried in the ROHC packets. The MAC PDU is sent. In this way, transmission resources are saved, and transmission efficiency is improved.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.

Abstract: A visual media de-identification system is described. The system includes an image merger and a de-identifying engine. The image merger is configured to merge a sequence of images from a set of visual media data into an averaged image. The de-identifying engine is configured to: bound portions of the averaged image that are determined to be relatively fixed, wherein each bounded portion is identified by a corresponding position in the averaged image; generate a template comprising the bounded portions and the corresponding position for each bounded portion in the averaged image; and de-identify the sequence of images by obfuscating content in the bounded portions.

Abstract: A method for de-identification of visual media data, including: merging a sequence of images from a set of visual media data into an averaged image; bounding portions of the averaged image that are determined to be relatively fixed, wherein each bounded portion is identified by a corresponding position in the averaged image; generating a template comprising the bounded portions and the corresponding position for each bounded portion in the averaged image; and de-identifying the sequence of images by obfuscating content in the bounded portions.

Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Abstract: A method for transmitting a header-compressed packet based on a retransmission mechanism is disclosed according to the present disclosure. The method mainly includes: a header compressor of a sending device obtains feedback information of a header-compressed packet in a transmission process; and the header compressor determines a state of the header compressor according to the feedback information, compresses a header for the packet according to the state of the header compressor, and sends the packet to a decompressor of a receiving device. According to the present disclosure, a header compression mechanism is combined with an automatic retransmission mechanism, so that the header compressor obtains feedback information of an automatic retransmission technology, and estimates the decompression information of the decompressor correctly, so as to change a state machine of the header compressor at proper time and improve transmission efficiency of the packet.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I), wherein X is O or N(R3); and R1, R2, R3 and Y are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: A method for transmitting a header-compressed packet based on a retransmission mechanism is disclosed according to the present disclosure. The method mainly includes: a header compressor of a sending device obtains feedback information of a header-compressed packet in a transmission process; and the header compressor determines a state of the header compressor according to the feedback information, compresses a header for the packet according to the state of the header compressor, and sends the packet to a decompressor of a receiving device. According to the present disclosure, a header compression mechanism is combined with an automatic retransmission mechanism, so that the header compressor obtains feedback information of an automatic retransmission technology, and estimates the decompression information of the decompressor correctly, so as to change a state machine of the header compressor at proper time and improve transmission efficiency of the packet.

Abstract: Embodiments of the present invention provide a data transmission method and apparatus. ROHC packets that use a same Context ID are encapsulated into MAC PDU, wherein the MAC PDU is formed by a MAC PDU packet header and a MAC PDU payload. The Context ID of the ROHC packets is carried in the MAC PDU packet header, and the Context ID is not carried in the ROHC packets. The MAC PDU is sent. In this way, transmission resources are saved, and transmission efficiency is improved.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, ?3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Abstract: Compounds having the structure: are HIV reverse transcriptase inhibitors, wherein A, X, Y, Z, R1 and R2 are defined herein. The compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.

Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.