Patents by Inventor Dale E. Shuster

Dale E. Shuster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
    Patent number: 7713950
    Abstract: Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CHX1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected halogens; and R3 is CH2Cl, CH2F, CHF2, CHCl2 or CH2OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: May 11, 2010
    Assignee: Intervet Inc.
    Inventors: Dale E. Shuster, Scott J. Hecker, Tomasz W. Glinka, Rajeshwar Singh, Zhuoyi Su
  • ANTIBACTERIAL 1-(4-MONO- AND DI-HALOMETHYLSULPHONYLPHENYL)-2-ACYLAMINO-3-FLUOROPROPONALS AND PREPARATION THEREOF
    Publication number: 20080146527
    Abstract: Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected halogens; and R3 is CH2Cl, CH2F, CHF2, CHCl2 or CH2OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
    Type: Application
    Filed: February 27, 2008
    Publication date: June 19, 2008
    Inventors: Dale E. Shuster, Scott Hecker, Tomasz W. Glinka, Rajeshwar Singh, Zhuoyi Su
  • Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
    Patent number: 7361689
    Abstract: Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected halogens; and R3 is CH2Cl, CH2F, CHF2, CHCl2 or CH2OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: April 22, 2008
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: Dale E. Shuster, Scott Hecker, Tomasz W. Glinka, Rajeshwar Singh, Zhuoyi Su
  • Florfenicol-type antibiotics
    Patent number: 7041670
    Abstract: The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: May 9, 2006
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: Constantine G. Boojamra, Lee S. Chong, Scott J. Hecker, Tomasz W. Glinka, Dale E. Shuster
  • Compositions and method for treating microbial and parasitic infections in cattle and other animals
    Publication number: 20040198704
    Abstract: Novel formulations combining an antiparasitic compounds, such as an avermectin, with a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as Florfenicol are disclosed. Methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease and parasitic infections are also disclosed.
    Type: Application
    Filed: April 2, 2004
    Publication date: October 7, 2004
    Applicant: Schering Corporation
    Inventors: Dale E. Shuster, David G. Sawutz, Kanwal J. Varma
  • Novel florfenicol-type antibiotics
    Publication number: 20040082553
    Abstract: The present invention relates to novel florfenicol compounds having the chemical structure: 1
    Type: Application
    Filed: April 8, 2003
    Publication date: April 29, 2004
    Inventors: Constantine G. Boojamra, Lee S. Chong, Scott J. Hecker, Tomasz W. Glinka, Dale E. Shuster
  • Diagnostic assays for genetic mutations associated with bovine leukocyte adhesion deficiency
    Patent number: 5234810
    Abstract: A point mutation in the CD18 gene responsible for causing bovine leukocyte adhesion deficiency (BLAD) and a silent mutation linked thereto have been identified. Nucleic acid sequences encompassing these mutations serve as bases for testing and identifying cattle alleles attributable to BLAD using any of a variety of diagnostic assays. Suitable nucleic acid probes and primers have also been designed for use in such assays.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: August 10, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Marcus E. Kehrli, Jr., Dale E. Shuster