Abstract: Provided are compositions of compounds effective for treating a pathology, the composition comprising at least two compounds that modulate the activity of one or more target molecules associated with one or more Single Nucleotide Polymorphisms (SNPs). Methods are also provided for increasing overall treatment efficacy for a population of patients having a pathology.

Abstract: Multiple fluid sample processors and systems for high throughput chemical synthesis and biological assays and/or processing. A multi-layered fluidic array having microchannels, reservoirs and reaction wells is subject to robotic and automated handling. A pressure pumping system is utilized for fluid delivery and control through the synthesis process. The sizes of the micro-sized channels, apertures, and valves are adjusted to optimize fluid distribution and channel filling. The fluid sample processors can be grouped together in a microtiter format to increase the speed, quantity and efficiency of the processing.

Abstract: Provided are compositions of compounds effective for treating a pathology, the composition comprising at least two compounds that modulate the activity of one or more target molecules associated with one or more Single Nucleotide Polymorphisms (SNPs). Methods are also provided for increasing overall treatment efficacy for a population of patients having a pathology.

Abstract: A method of programming a programmable controller in a manner by which a variety of menus, options, or questions seeking limited parameter answers are presented to the user; for example, setup parameters such as the type of labware, source and destination of reagent transfer etc. for conducting a particular biological and chemical assay experiments by an automated laboratory workstation. Software "templates" are used to focus the request for parameters from the user to tailor user needs to the laboratory workstation's capabilities. The software templates are designed to accommodate a wide variety of experimental setups in accordance with the setup parameters input by the user. By providing the parameters with the assistance of the templates, the user may program a complete set of instructions for conducting a biological or chemical assay. The instructions may include the time and method for undertaking the experiment.

Abstract: A telescoping pool cue or similar ball-striking device wherein a continuously variable amount of energy is stored. A main spring within an elongated handle is held in compression by a ratchet and pawl which provides an audible or visible signal of the amount of stored energy. A telescoping member may be marked with vernier indicia to visibly indicate the amount of stored energy or an electronic display provided. The main spring urges an outer plunger forwardly, but an actuator spring urges an inner plunger rearwardly. Upon release, the inner plunger moves rearward to release the pawl and ratchet after which both plungers move forwardly. This reciprocal action allows the cue to begin and end a stroke near the desired point of impact.

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The work station combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.

Abstract: A liquid boundary level detector employing an open-ended conduit which directs pressure waves toward a liquid boundary layer. The conduit is moved from a starting position toward the liquid boundary and, upon contact with the boundary, there is a change in acoustic impedance within the conduit. This change is monitored and a signal is generated indicative of such contact. Once the initial liquid boundary position is determined, that may become the reference position for subsequent liquid boundary measurements or motions.

Abstract: A laser tape system for use in the resonant cavity of laser consisting of a flexible tape carrying at least one lasing dye and adapted for insertion into the resonant cavity, and a drive mechanism for moving the tape such that different portions of the tape may be focused within the cavity.