Abstract: A system and process are provided for analyzing nucleic acid data. An example process can include receiving nucleic acid data including a set of sequence data. The nucleotides of the sequence data can be assigned numerical values. Using these assigned values, partial sums can be calculated for each position in the set of sequence data. The resulting sums can then be displayed in form of Charts or Maps which is so called sequence spectrum to make it easy to navigate and analyze the whole data set. In some examples, patterns or similar/identical sequence segments can be identified within a single set of sequence data or between different sets of sequence data in the spectrum.

Abstract: The invention provides a blood-based noninvasive early lung cancer detection method, which investigates a panel of miRNA levels in a blood or plasma sample. The panel of miRNA includes miR-17, miR-21, miR-24, miR-106a, miR-125b, miR-128, miR-155, miR-182, miR-183, miR-197, miR-199b, miR-203, miR-205, miR-210, miR-221, and a combination thereof. Preferably, the panel of miRNA may include miR-21, miR-128, miR-155, miR-182, miR-183, and miR-197. The inventive method can not only detect stage I lung cancer patients with high accuracy, but also differentiate between all stages of lung cancer patients and lung cancer-free individuals, metastatic and non-metastatic lung cancer patients and monitor the significant changes of miRNA levels during chemotherapy.

Abstract: Provided are new and improved methods for detecting circulating tumor cells and tumor cell DNA in patient blood or other biofluid samples. Particular aspects comprise three steps: DNA extraction from patient samples, DNA digestion with multiple selected methylation-sensitive enzymes, and target amplification by a conventional or a real-time PCR with specific probe and/or primers. Also provided are a total of 40 tumor-specific DNA methylation loci as biomarkers having substantial utility and specificity in major types of human malignancies including hematopoietic and solid tumors.

Abstract: This invention provides a strong magnetism therapeutic apparatus with permanent-magnet sets rotating at low frequency in which a base set made of magnetic material is fixed on a plate capable of rotating in both direction and at least two adjacent permanent-magnet sets for producing strong magnetic field are secured to said base set and separated by a isolating block made of non-magnetic material. A pole head is secured to the upper surface of each permanent-magnet set. The penetrating depth within the object to be treated is up to 500 mm. When used as a therapeutic instrument, this apparatus can produce desirable analgesic effect for late patient of, for example, cancer without the minus effect of radiation therapy and chemotherapy. The apparatus has also wide application in biologic and chemical field.