Patents by Inventor Dalit Barkan

Dalit Barkan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apoptosis related protein in the tgf-beta signaling pathway (ARTS) mimetic compounds, compositions, methods and uses thereof in induction of differentiation and/or apoptosis of premalignant and malignant cells, thereby restoring their normal-like phenotype
    Patent number: 11866409
    Abstract: Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: January 9, 2024
    Assignee: CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.
    Inventors: Sarit Larisch, Dalit Barkan
  • APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF DIFFERENTIATION AND/OR APOPTOSIS OF PREMALIGNANT AND MALIGNANT CELLS, THEREBY RESTORING THEIR NORMAL-LIKE PHENOTYPE
    Publication number: 20180230096
    Abstract: Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.
    Type: Application
    Filed: November 2, 2016
    Publication date: August 16, 2018
    Applicant: CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.
    Inventors: Sarit LARISCH, Dalit BARKAN
  • CD11 B[low] MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
    Publication number: 20170340670
    Abstract: A conditioned cell culture medium of CD11blow human macrophages or a biologically active fraction thereof can be prepared by a method that includes (i) culturing a population of human mononuclear cells of the monocyte/macrophage lineage for 5-7 days, so as to induce differentiation of the mononuclear cells to macrophages; (ii) incubating the macrophages obtained in (i) with apoptotic cells or in the presence of a pro-resolving lipid mediator to reduce the CD11b expression, thus obtaining a culture of CD11blow macrophages; and (iii) collecting the conditioned cell culture medium of CD11blow macrophages. Pharmaceutical compositions containing the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages can be used in the treatment of cancer or fibrosis.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 30, 2017
    Inventors: Dalit Barkan, Odelya Gilon, Amiram Ariel, Sagie Schif-Zuck, Aroesti-Assi Simaan
  • CD11 B[low] macrophages and conditioned media thereof for treating cancer and/or fibrosis
    Patent number: 9724366
    Abstract: A conditioned medium of CD11blow macrophages and methods for preparing it are provided. Pharmaceutical compositions comprising the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages and their use in the treatment of cancer or fibrosis are also provided.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: August 8, 2017
    Assignee: Carmel-Haifa University Economic Corporation Ltd
    Inventors: Dalit Barkan, Odelya Gilon, Amiram Ariel, Sagie Schif-Zuck, Aroesti-Assi Simaan
  • CD11 B[low] MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
    Publication number: 20150342992
    Abstract: A conditioned medium of CD11blow macrophages and methods for preparing it are provided. Pharmaceutical compositions comprising the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages and their use in the treatment of cancer or fibrosis are also provided.
    Type: Application
    Filed: December 30, 2013
    Publication date: December 3, 2015
    Applicant: CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD
    Inventors: Dalit BARKAN, Odelya GILON, Amiram ARIEL, Sagie SCHIF-ZUCK
  • Leptin as an inhibitor of tumor cell proliferation
    Patent number: 7109159
    Abstract: The use of leptin and leptin-related molecules in oncology is disclosed.
    Type: Grant
    Filed: April 26, 1998
    Date of Patent: September 19, 2006
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Dalit Barkan, Batya Cohen, Menachem Rubinstein
  • Use of leptin in fertility
    Publication number: 20050065080
    Abstract: The present invention relates to the use of leptin in treating infertility and particularly to the use of leptin in triggering ovulation.
    Type: Application
    Filed: November 21, 2002
    Publication date: March 24, 2005
    Inventors: Dalit Barkan, Nava Dekel, Menachem Rubinstein, Vladimir Hurgin