Patents by Inventor Damian Curtin
Damian Curtin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10513729Abstract: Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.Type: GrantFiled: February 26, 2016Date of Patent: December 24, 2019Assignee: STOKES BIO LIMITEDInventors: Mauro Aguanno, Brian T. Chawke, Kieran Curran, Tara Dalton, Mark Davies, Xiaona Hou, David Kinahan, Mark Korenke, David McGuire, Michael Sayers, Noel Sirr, Ryan J. Talbot, Brian Barrett, Damian Curtin, Damien King, Conor McCarthy
-
Publication number: 20180256174Abstract: An arthroscopic surgical tool arrangement for performing endoscopic surgical procedures which includes a powered handpiece and a cutting accessory which detachably connects to the handpiece is provided. The cutting accessory has a distal end which defines a cutting head incorporating diamond-grit particles.Type: ApplicationFiled: February 15, 2018Publication date: September 13, 2018Inventors: Bryan DEENY, Patrick CUSHEN, Damian CURTIN, James O'CONNOR
-
Patent number: 9897596Abstract: The invention relates to a microfluidic system for processing biological samples comprising a rotary motor; a means for controlling said motor; a platform coupled to the rotary motor and adapted to provide at least one particle-washing structure and one particle receiving structure for receiving washed particles; and a detection zone for detection of particles of the sample in the particle receiving structure while the platform rotates. The invention provides a sample processing system that is both automated and prone to fewer errors than manual processing. This is accomplished using a centrifugal microfluidic platform that can process raw biological samples (e.g., blood, sputum, urine,) in order to perform high-quality bead-based immunofluorescent assays. The invention uses a simple rotary motor and custom-designed plastic disc to perform the sample preparation steps outlined above.Type: GrantFiled: June 5, 2012Date of Patent: February 20, 2018Assignee: Radisens Diagnostics LimitedInventors: Greg Kellogg, Jerry O'Brien, Eoin O'Nuallain, Damian Curtin
-
Publication number: 20160340715Abstract: Systems and methods are used to detect spectral and spatial information in a continuous flow PCR system. An incident beam of electromagnetic radiation is emitted using a laser. The incident beam is received from the laser and the incident beam is transformed into an incident line of electromagnetic radiation using a line generator. The incident line is received from the line generator using a tube array that includes one or more transparent tubes in fluid communication with one or more micro-channels. Reflected electromagnetic radiation is received from the tube array and the reflected electromagnetic radiation is focused using an imaging lens. The focused reflected electromagnetic radiation is received from the imaging lens and a spectral intensity is detected from the focused reflected electromagnetic radiation using a spectrograph. The focused reflected electromagnetic radiation is received from the imaging lens and a location of the spectral intensity is detected using an imager.Type: ApplicationFiled: May 23, 2016Publication date: November 24, 2016Inventors: Mauro Aguanno, Damian Curtin, Damien King
-
Publication number: 20160281135Abstract: Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.Type: ApplicationFiled: February 26, 2016Publication date: September 29, 2016Inventors: Mauro Aguanno, Brian T. Chawke, Kieran Curran, Tara Dalton, Mark Davies, Xiaona Hou, David Kinahan, Mark Korenke, David McGuire, Michael Sayers, Noel Sirr, Ryan J. Talbot, Brian Barrett, Damian Curtin, Damien King, Conor McCarthy
-
Publication number: 20150352513Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries help in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: ApplicationFiled: August 17, 2015Publication date: December 10, 2015Inventors: Mark Davies, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin
-
Publication number: 20150316542Abstract: The invention relates to a microfluidic system and method of processing biological samples in microfluidic system comprising the steps of the steps of positioning at least one detection chamber adapted for receiving particles, said particles comprising a reference label and reporter label, wherein the labels exhibit different wavelength properties when irradiated with light; and normalising the particle reporter label by using any detected magnitude in the measured properties of the reference label.Type: ApplicationFiled: December 5, 2013Publication date: November 5, 2015Inventor: Damian Curtin
-
Patent number: 9108177Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: GrantFiled: October 18, 2013Date of Patent: August 18, 2015Assignee: Stokes Bio LimitedInventors: Mark Davies, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin
-
Publication number: 20140308671Abstract: The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including: a sampling member for acquiring or dispensing a sample; and a supply of a fluid that is immiscible with the sample; in which the device is configured to provide a continuous flow of immiscible fluid enveloping the sampling member.Type: ApplicationFiled: April 11, 2014Publication date: October 16, 2014Applicant: STOKES BIO LIMITEDInventors: David McGuire, Kieran Curran, Julie Garvey, Damian Curtin
-
Publication number: 20140242721Abstract: The invention relates to a microfluidic system for processing biological samples comprising a rotary motor; a means for controlling said motor; a platform coupled to the rotary motor and adapted to provide at least one particle-washing structure and one particle receiving structure for receiving washed particles; and a detection zone for detection of particles of the sample in the particle receiving structure while the platform rotates. The invention provides a sample processing system that is both automated and prone to fewer errors than manual processing. This is accomplished using a centrifugal microfluidic platform that can process raw biological samples (e.g., blood, sputum, urine,) in order to perform high-quality bead-based immunofluorescent assays. The invention uses a simple rotary motor and custom-designed plastic disc to perform the sample preparation steps outlined above.Type: ApplicationFiled: June 5, 2012Publication date: August 28, 2014Applicant: RADISENS DIAGNOSTICS LTD.Inventors: Greg Kellogg, Jerry O'Brien, Eoin O'Nuallain, Damian Curtin
-
Publication number: 20140127701Abstract: Systems and methods are used to detect spectral and spatial information in a continuous flow PCR system. An incident beam of electromagnetic radiation is emitted using a laser. The incident beam is received from the laser and incident beam is transformed into an incident line of electromagnetic radiation using a line generator. The incident line is received from the line generator using a tube array that includes one or more transparent tubes in fluid communication with one or more micro-channels. Reflected electromagnetic radiation is received from the tube array and the reflected electromagnetic radiation is focused using an imaging lens. The focused reflected electromagnetic radiation is received from the imaging lens and a spectral intensity is detected from the focused reflected electromagnetic radiation using a spectrograph. The focused reflected electromagnetic radiation is received from the imaging lens and a location of the spectral intensity is detected using an imager.Type: ApplicationFiled: April 6, 2012Publication date: May 8, 2014Applicant: STOKES BIO LIMITEDInventors: Mauro Aguanno, Damian Curtin, Damien King
-
Publication number: 20140120604Abstract: Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.Type: ApplicationFiled: April 6, 2012Publication date: May 1, 2014Applicant: STOKES BIO LIMITEDInventors: Mauro Aguanno, Brian Barrett, Brian Chawke, Kieran Curran, Damian Curtin, Tara Dalton, Mark Davies, Xiaona Hou, David Kinahan, Damien King, Mark Korenke, Conor McCarthy, David McGuire, Michael Sayers, Noel Sirr, Ryan J. Talbot
-
Publication number: 20140051604Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: ApplicationFiled: October 18, 2013Publication date: February 20, 2014Applicant: STOKES BIO LIMITEDInventors: Mark Davies, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin
-
Patent number: 8563244Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: GrantFiled: July 6, 2011Date of Patent: October 22, 2013Assignee: Stokes Bio LimitedInventors: Mark Davies, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin
-
Publication number: 20120003658Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: ApplicationFiled: July 6, 2011Publication date: January 5, 2012Applicant: STOKES BIO LIMITEDInventors: Mark DAVIES, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin
-
Patent number: 7993911Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: GrantFiled: February 7, 2007Date of Patent: August 9, 2011Assignee: Stokes Bio LimitedInventors: Mark Davies, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin
-
Publication number: 20100015606Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow.Type: ApplicationFiled: February 7, 2007Publication date: January 21, 2010Applicant: STOKES BIO LIMITEDInventors: Mark Davies, Tara Dalton, Julie Garvey, Kieran Curran, Damian Curtin