Abstract: A flexible coaxial tissue sampling device, comprising: a sheath; a displaceable wire within the sheath having a first end extending from a proximal end of the sheath and second end which extends, in a first state, from a distal end of the sheath, and in a second state, retracts into the distal end of the sheath; the second end of the displaceable wire comprising a cellular sampling structure and a porous absorptive material which are external to the sheath in the first state and internal in the second state. A tension on the first end of the displaceable wire at the proximal end of the sheath retracts the displaceable wire from the first state to the second state, along with the cellular sampling structure and the porous absorptive material. The porous absorptive material retains a fluid sample after retraction and protects against contact of the sample with other tissues.

Abstract: A biopsy device, comprising a flexible coaxial structure, comprising a wire within a sheath, the wire being adapted to be displaced with respect to the sheath along the coaxial axis by a force applied at a proximal end; a disruptor, at a distal end of the obturator, adapted to disrupt a tissue surface to free cells therefrom, having a first position covered within the sheath and a second position freely extending beyond the sheath; an element, on an exterior of the sheath, configured to limit a depth of insertion of the sheath into a body orifice.

Abstract: A biopsy device, comprising a flexible coaxial structure, comprising an obturator within a sheath, the obturator being adapted to be displaced with respect to the sheath along the coaxial axis by a force applied at a proximal end; a disruptor, at a distal end of the obturator, adapted to disrupt a tissue surface to free cells therefrom, having a first position covered within the sheath and a second position freely extending beyond the sheath; an element, having a fixed position on the sheath, configured to limit a depth of insertion of the sheath into a cervix.

Abstract: A biopsy device, comprising a flexible coaxial structure, comprising an obturator within a sheath, the obturator being adapted to be displaced with respect to the sheath along the coaxial axis by a force applied at a proximal end; a disruptor, at a distal end of the obturator, adapted to disrupt a tissue surface to free cells therefrom, having a first position covered within the sheath and a second position freely extending beyond the sheath; an element, having a fixed position on the sheath, configured to limit a depth of insertion of the sheath into a cervix.