Patents by Inventor Damon Jude Wischik
Damon Jude Wischik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230346794Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of a acetylcholinesterase levels.Type: ApplicationFiled: April 6, 2023Publication date: November 2, 2023Applicant: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Bjorn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Patent number: 11759469Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.Type: GrantFiled: June 16, 2021Date of Patent: September 19, 2023Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Bjorn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Publication number: 20230165877Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.Type: ApplicationFiled: October 7, 2022Publication date: June 1, 2023Applicant: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Bjorn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Publication number: 20220172821Abstract: A method, a computer implemented method, and a device, all for adaptively testing a subjects neurological state. The method comprising the steps of: administering one or more seed questions; obtaining one or more answer(s) to the one or more seed questions; calculating a score value of a latent subject trait from the answers to the one or more seed questions; the method comprising an adaptive test loop, comprising: (a) selecting, based on the score value, one or more further questions from a bank of questions; (b) administering the one or more further questions to the subject; (c) updating the score value based on the answers to the one or more further questions; (d) determining whether a test completion criteria has been met; wherein the method repeats steps (a)-(d) in sequence until the test completion criteria has been met, and provides an output of the test based on the score value which is indicative of the subjects neurological state.Type: ApplicationFiled: April 6, 2020Publication date: June 2, 2022Inventors: Helen Christine Shiells, Suzannah Marie Morson, Björn Olaf Schelter, Damon Jude Wischik, Claude Michel Wischik
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Publication number: 20220008431Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.Type: ApplicationFiled: June 16, 2021Publication date: January 13, 2022Applicant: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Bjorn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Patent number: 11065256Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.Type: GrantFiled: July 25, 2017Date of Patent: July 20, 2021Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Bjorn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Patent number: 11022454Abstract: A system for reconstructing vehicle itinerary include a processor and a memory storing instructions, implemented by the processor, to cluster historical trip records into a plurality of clusters, each of the plurality of clusters including a set of historical trip records that describe events occurring within a predetermined time range at one location; identify a sequence of clusters that includes a cluster at each location; and estimate an itinerary for a vehicle based on the sequence of clusters and constraint data describing physical constraints, the itinerary for the vehicle describing a sequence of arrival and departure times at a sequence of locations for the vehicle.Type: GrantFiled: March 12, 2018Date of Patent: June 1, 2021Assignee: GOOGLE LLCInventors: Morteza Ibrahimi, Damon Jude Wischik, Christopher David Pluntke, Balaji Satyanarayana Prabhakar, Deepak Merugu
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Patent number: 10842796Abstract: The invention describes improved treatments for Frontotemporal dementia based on the use of a methylthioninium compound in combination with a compound which directly modifies synaptic neurotransmission in the brain, such as a symptomatic Alzheimer's disease treatment (e.g. acetylcholinesterase and/or memantine).Type: GrantFiled: August 25, 2017Date of Patent: November 24, 2020Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Björn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Publication number: 20200016165Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.Type: ApplicationFiled: July 25, 2017Publication date: January 16, 2020Inventors: Claude Michel Wischik, Bjorn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Publication number: 20190192530Abstract: The invention describes improved treatments for Frontotemporal dementia based on the use of a methylthioninium compound in combination with a compound which directly modifies synaptic neurotransmission in the brain, such as a symptomatic Alzheimer's disease treatment (e.g. acetylcholinesterase and/or memantine).Type: ApplicationFiled: August 25, 2017Publication date: June 27, 2019Applicant: Wis Ta Laboratories Ltd.Inventors: Claude Michel Wischik, Björn Olaf Schelter, Damon Jude Wischik, John Mervyn David Storey
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Publication number: 20190151329Abstract: Described are methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.Type: ApplicationFiled: January 15, 2019Publication date: May 23, 2019Applicant: WisTa Laboratories Ltd.Inventors: Claude Michel WISCHIK, Damon Jude WISCHIK, John Mervyn David STOREY, Charles Robert HARRINGTON
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Patent number: 10188658Abstract: Described are methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimized pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.Type: GrantFiled: September 25, 2015Date of Patent: January 29, 2019Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Damon Jude Wischik, John Mervyn David Storey, Charles Robert Harrington
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Publication number: 20180202827Abstract: A system for reconstructing vehicle itinerary include a processor and a memory storing instructions, implemented by the processor, to cluster historical trip records into a plurality of clusters, each of the plurality of clusters including a set of historical trip records that describe events occurring within a predetermined time range at one location; identify a sequence of clusters that includes a cluster at each location; and estimate an itinerary for a vehicle based on the sequence of clusters and constraint data describing physical constraints, the itinerary for the vehicle describing a sequence of arrival and departure times at a sequence of locations for the vehicle.Type: ApplicationFiled: March 12, 2018Publication date: July 19, 2018Inventors: Morteza Ibrahimi, Damon Jude Wischik, Christopher David Pluntke, Balaji Satyanarayana Prabhakar, Deepak Merugu
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Patent number: 9915542Abstract: A system for reconstructing vehicle itinerary include a processor and a memory storing instructions, implemented by the processor, to cluster historical trip records into a plurality of clusters, each of the plurality of clusters including a set of historical trip records that describe events occurring within a predetermined time range at one location; identify a sequence of clusters that includes a cluster at each location; and estimate an itinerary for a vehicle based on the sequence of clusters and constraint data describing physical constraints, the itinerary for the vehicle describing a sequence of arrival and departure times at a sequence of locations for the vehicle.Type: GrantFiled: December 19, 2014Date of Patent: March 13, 2018Assignee: GOOGLE LLCInventors: Morteza Ibrahimi, Damon Jude Wischik, Christopher David Pluntke, Balaji Satyanarayana Prabhakar, Deepak Merugu
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Publication number: 20160030444Abstract: Described are methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.Type: ApplicationFiled: September 25, 2015Publication date: February 4, 2016Applicant: WisTa Laboratories Ltd.Inventors: Claude Michel WISCHIK, Damon Jude WISCHIK, John Mervyn David STOREY, Charles Robert HARRINGTON
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Patent number: 9211294Abstract: The present invention relates generally to methods and materials based on diaminophenothiazines for use in the treatment of Mild Cognitive Impairment (MCI).Type: GrantFiled: June 17, 2008Date of Patent: December 15, 2015Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Dominic Venay Harbaran, Gernot Riedel, Serena Deiana, Elizabeth Anne Goatman, Damon Jude Wischik, Alison Dorothy Murray, Roger Todd Staff
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Patent number: 9149481Abstract: The present invention relates generally to methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.Type: GrantFiled: October 1, 2008Date of Patent: October 6, 2015Assignee: WisTa Laboratories Ltd.Inventors: Claude Michel Wischik, Damon Jude Wischik, John Mervyn David Storey, Charles Robert Harrington
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Publication number: 20150177011Abstract: A system for reconstructing vehicle itinerary include a processor and a memory storing instructions, implemented by the processor, to cluster historical trip records into a plurality of clusters, each of the plurality of clusters including a set of historical trip records that describe events occurring within a predetermined time range at one location; identify a sequence of clusters that includes a cluster at each location; and estimate an itinerary for a vehicle based on the sequence of clusters and constraint data describing physical constraints, the itinerary for the vehicle describing a sequence of arrival and departure times at a sequence of locations for the vehicle.Type: ApplicationFiled: December 19, 2014Publication date: June 25, 2015Inventors: Morteza Ibrahimi, Damon Jude Wischik, Christopher David Pluntke, Balaji Satyanarayana Prabhakar, Deepak Merugu
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Publication number: 20100290986Abstract: The present invention relates generally to methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.Type: ApplicationFiled: October 1, 2008Publication date: November 18, 2010Inventors: Claude Michel Wischik, Damon Jude Wischik, John Mervyn David Storey, Charles Robert Harrington
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Publication number: 20100280975Abstract: The invention provides methods and systems for assessing the efficacy of a pharmaceutical which is putatively disease modifying of a cognitive disorder, for use in the treatment or prophylaxis of that cognitive disorder, the method comprising the steps of: (1) stratifying a subject group into at least 2 sub-groups according to a baseline indicator of likely disease progression, (2) treating members of each subject group with the pharmaceutical for a treatment time frame, (3) deriving psychometric and optionally physiological outcome measures for each treated patient group, (4) comparing the outcomes at (3) with a comparator arm of said sub-groups which is optionally a placebo or minimal efficacy comparator arm, (5) using the comparison in (4) to derive an efficacy measure for the pharmaceutical.Type: ApplicationFiled: November 5, 2008Publication date: November 4, 2010Inventors: Claude Michel Wischik, Damon Jude Wischik, Roger Todd Staff, Alison Dorothy Murray