Patents by Inventor Dan E. Berkowitz

Dan E. Berkowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF NITRIC OXIDE AND DELIVERY SYSTEMS
    Publication number: 20230321386
    Abstract: Provided herein are NO generating systems, methods for generating NO for inhaled therapy, and methods of treating patients in need of inhaled NO. The systems can include a reaction vessel having a headspace for NO accumulation, a NO storage system, and a gas mixing chamber. NO gas generated in the reaction vessel can be delivered to the NO storage system via pressure generated by generation of the NO gas, then the NO gas is mixed with a carrier gas in a gas mixing chamber. NO can be generated at the point of patient delivery.
    Type: Application
    Filed: August 20, 2021
    Publication date: October 12, 2023
    Inventors: Nagababu ENIKA, Dan E. BERKOWITZ
  • HDAC2 DEFENDS VASCULAR ENDOTHELIUM FROM INJURY
    Publication number: 20160199463
    Abstract: The invention features compositions comprising HDAC2 and methods for protecting the vascular endothelium from injury.
    Type: Application
    Filed: December 15, 2015
    Publication date: July 14, 2016
    Inventors: Lewis Romer, Deepesh Pandey, Dan E. Berkowitz
  • COMPOSITIONS AND METHODS OF TREATING ENDOTHELIAL DISORDERS
    Publication number: 20120065165
    Abstract: Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic combination of at least one arginase inhibitor and at least one phosphodiesterase (PDE1), (PDE2) and/or (PDE5) inhibitor are described.
    Type: Application
    Filed: November 2, 2009
    Publication date: March 15, 2012
    Applicant: ARGINETIX, INC
    Inventors: Simon E. Aspland, Dan E. Berkowitz, Trinity Bivalacqua, Hunter Champion
  • ARGINASE II: A TARGET FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS
    Publication number: 20110184052
    Abstract: The instant invention provides methods and compositions for the treatment of. atherosclerotic disease. Specifically, the invention provides methods and compositions for modulating the activity of Arginase II, the production of Arginase II or the amount of free Arginase II for the treatment of atherosclerotic disease.
    Type: Application
    Filed: December 21, 2010
    Publication date: July 28, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Dan E. Berkowitz, Sungwoo Ryoo, Artin A. Shoukas, Gaurav Gupta, Lewis Romer
  • SELECTIVE FLUORESCENT LABELING OF S-NITROSOTHIOLS (S-FLOS): A NOVEL METHOD FOR STUDYING S-NITROSYLATION
    Publication number: 20100025245
    Abstract: A method and kit for selectively labeling S-nitrosylated cysteines in proteins with a fluorescent tag. The method offers femtomolar sensitivity for the detection, quantification, in situ visualization, and a means for site-specific identification of S-nitrosylation events.
    Type: Application
    Filed: September 20, 2007
    Publication date: February 4, 2010
    Applicant: Johns Hopkins Univeristy
    Inventors: Robert N. Cole, Dan E. Berkowitz, Lakshmi Santhanam, Artin Andrew Shoukas
  • Arginase II: A Target treatment of aging heart and heart failure
    Publication number: 20090298912
    Abstract: The instant invention provides methods and compositions for the treatment of cardiac dysfunction. Specifically, the invention provides methods and compositions for modulating Arginase II for the treatment of cardiac dysfunction.
    Type: Application
    Filed: June 29, 2006
    Publication date: December 3, 2009
    Applicant: The Johns Hopkins University
    Inventors: Dan E. Berkowitz, Joshua M. Hare, Artin A. Shoukas, Hunter Champion, Jochen Steppan
  • Arginase II: a target for the prevention of atherosclerosis
    Publication number: 20090181010
    Abstract: The instant invention provides methods and compositions for the treatment of. atherosclerotic disease. Specifically, the invention provides methods and compositions for modulating the activity of Arginase II, the production of Arginase II or the amount of free Arginase II for the treatment of atherosclerotic disease.
    Type: Application
    Filed: September 23, 2008
    Publication date: July 16, 2009
    Applicant: The Johns Hopkins University
    Inventors: Dan E. Berkowitz, Sungwoo Ryoo, Artin A. Shoukas, Gaurav Gupta, Lewis Romer