Patents by Inventor Dan I. PIRANER

Dan I. PIRANER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modular dimerization thermoswitches and related monomers, dimers, constructs, dimeric complexes, vectors, cells, surfaces, devices compositions, methods and systems
    Patent number: 11965001
    Abstract: Provided herein are thermomer monomer, thermomer dimers, thermomer monomeric constructs, thermomer dimeric complexes, and related gene expression cassette vectors, cells, surfaces devices, compositions methods and systems, that provide a thermobioswitch suitable to control location and/or binding of cargo moiety of interest in a temperature regulated manner.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: April 23, 2024
    Assignee: California Institute of Technology
    Inventors: Dan I. Piraner, Mikhail Shapiro
  • THERMAL CONTROL OF T-CELL IMMUNOTHERAPY THROUGH MOLECULAR AND PHYSICAL ACTUATION
    Publication number: 20210324389
    Abstract: Disclosed herein include methods, compositions, and kits suitable for use in spatiotemporal regulation of therapeutic T-cells through a combination of molecular and physical actuation. There are provided, in some embodiments, thermal bioswitches that allow T-cells to sense small changes in temperature and use them as inputs for the actuation of genetic circuits. Also disclosed herein are T cell activity sensors. Genetic circuits capable of inducing expression of a payload upon thermal stimulation and/or immune cell stimulation are provided. There are provided, in some embodiments, thermally actuated immune cells and methods of using are provided. Oscillator circuits and methods of preventing T cell exhaustion are also disclosed.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Inventors: Mohamad H. Abedi, Mikhail Shapiro, Dan I. Piraner, Justin Lee
  • THERMAL BIOSWITCHES AND RELATED GENETIC CIRCUITS, VECTORS, CELLS, COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20210277453
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Application
    Filed: March 17, 2021
    Publication date: September 9, 2021
    Inventors: Mikhail G. SHAPIRO, Dan I. PIRANER, Mohamad H. ABEDI, Brittany MOSER, Audrey LEE-GOSSELIN
  • Thermal bioswitches and related genetic circuits, vectors, cells, compositions, methods and systems
    Patent number: 10975420
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: April 13, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Mikhail G. Shapiro, Dan I. Piraner, Mohamad H. Abedi, Brittany Moser, Audrey Lee-Gosselin
  • MODULAR DIMERIZATION THERMOSWITCHES AND RELATED MONOMERS, DIMERS, CONSTRUCTS, DIMERIC COMPLEXES, VECTORS, CELLS, SURFACES, DEVICES COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20210040161
    Abstract: Provided herein are thermomer monomer, thermomer dimers, thermomer monomeric constructs, thermomer dimeric complexes, and related gene expression cassette vectors, cells, surfaces devices, compositions methods and systems, that provide a thermobioswitch suitable to control location and/or binding of cargo moiety of interest in a temperature regulated manner.
    Type: Application
    Filed: July 13, 2020
    Publication date: February 11, 2021
    Inventors: Dan I. PIRANER, Mikhail SHAPIRO
  • THERMAL BIOSWITCHES AND RELATED GENETIC CIRCUITS, VECTORS, CELLS, COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20170298425
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Application
    Filed: December 19, 2016
    Publication date: October 19, 2017
    Inventors: Mikhail G. SHAPIRO, Dan I. PIRANER, Mohamad H. ABEDI, Brittany MOSER, Audrey LEE-GOSSELIN