Abstract: A dense thick alloy coating with no layered organizational structure and a preparation method thereof are provided. The preparation method includes the following steps: step 1, placing a substrate in a plasma spraying apparatus, controlling a vacuum degree of the plasma spraying apparatus to be 0.2 mbar-0.5 mbar, controlling a length of a plasma flame of the plasma spraying apparatus to be 1000 mm-1200 mm, and controlling a diameter of the plasma flame to be 200 mm-300 mm; step 2, preheating, by using a plasma spray gun, the substrate to a temperature of 700° C.-1000° C. to obtain a preheated substrate; step 3, plasma spraying an alloy powder on the preheated substrate under a specific plasma spraying condition to obtain a sprayed substrate; and step 4, cooling the sprayed substrate after the plasma spraying, to thereby obtain the dense thick alloy coating without layered organizational structure.

Abstract: A titanium alloy blade tip with a wear-resistant protective coating and a preparation method thereof are provided. The method includes: (1) spraying MCrAlY alloy powder on a surface of a titanium alloy blade tip by high velocity oxygen fuel (HVOF) spraying at a spraying distance of 300-400 mm to obtain the titanium alloy blade tip with a MCrAlY layer on the surface; where M is one of Ni and NiCo; (2) pre-plating Ni at a current density of 4-10 A/dm2; (3) placing the pre-plated titanium alloy blade tip in a Watt solution, covering a surface of the pre-plated titanium alloy blade tip obtained in the step (2) with abrasive particles, and then performing composite electroplating at a current density of 0.5-2 A/dm2. In the method, the wear-resistant protective coating with the high adhesion strength is prepared on the titanium alloy blade tip, and the wear-resistant protective coating has good wear resistance.

Abstract: Provided are a content typesetting method and apparatus, a computer device, and a storage medium. The method includes: acquiring each text element in content to be typeset as well as the element type of each text element (S101); determining rendering size information of each text element on the basis of the element type of each text element and a preset rendering size relationship between element types indicated by a movable character template (S102); and on the basis of the rendering size information of each text element and typesetting style setting information, typesetting the content to be typed (S103). The rendering size of each text element can be determined according to the element type, which avoids a process where the rendering size of each text element needs to be separately measured each time typesetting is performed, thereby improving the computation efficiency of rendering size, and improving typesetting efficiency.

Abstract: A career aspiration-based educational method and system. The educational method includes: according to the user information, determining and recommending an ideal occupational role for the user to select a target occupational role (S102); searching in a ability and knowledge system library of career roles so as to determine a ability and knowledge system required for the target career role, and pre-establishing a ability and knowledge system library of the career role by means of collecting occupational qualification data (S104); customizing a personalized course system for the user according to the capability and knowledge system required for the target occupational role (S106); and providing the teaching of a corresponding course to the user according to the personalized course system (S108).

Abstract: A fully-automatic aluminum thermal-spraying corrosion prevention production line based on robots and visual recognition is provided. The production line comprises an automatic feeding system comprising feeding carrying and conveying mechanisms; a laser derusting system comprising a derusting robot, a laser cleaning nozzle and derusting conveying mechanisms; an aluminum thermal-spraying system comprising an aluminum spraying robot and an aluminum thermal-spraying gun; an automatic rolling system comprising a rolling pedestal, a first rolling wheel, a second rolling wheel and a rolling drive mechanism; a laser cutting system; and a discharging and stacking system.

Abstract: The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL 15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-L1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.

Abstract: Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The iPSC-derived cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the use thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.

Abstract: Disclosed are a method of underlying drive forwarding and a multi-core system implemented based on a UEFI, which can increase a running speed of the multi-core system implemented based on a UEFI. The underlying drive forwarding method is configured for underlying drive forwarding of a multi-core system. The multi-core system is implemented based on a UEFI and includes an application processor and a bootstrap processor. The bootstrap processor is provided with an execution interface configured to call underlying hardware. The application processor is configured with an instruction interface corresponding to the execution interface.

Abstract: The present disclosure relates to a memory test system and a memory test method. The memory test system comprises: a plurality of test devices, a host computer, and driving modules. Each of the test devices is provided with a test interface used for connecting a memory to be tested. The host computer is respectively connected to the plurality of test devices and configured to control the test devices to test the memory to be tested. The driving modules are connected to the test devices and configured to output, to the test devices, driving signals used for driving the test devices to perform data interaction with the host computer.

Abstract: Provided herein are recombinant antibodies, antigen-binding fragments, and fusion proteins thereof useful for binding to and inhibiting programmed death 1 (PD-1), nucleic acid molecules encoding the same and therapeutic compositions thereof, as well as methods of using such antibodies, including the methods for enhancing T cell and NK cell function to increase cell and cytokine mediated immunity and methods of treatment of various immune dysfunction related disorders including cancer and infectious diseases.

Abstract: The present disclosure provides two specific T cell receptors targeting a G12V or G12C mutant epitope of a KRAS gene, and an anti-tumor use thereof. Each of the two T cell receptors consists of an ? peptide chain and a ? peptide chain. Further provided are an antigen binding fragment of the T cell receptors, a nucleic acid encoding the T cell receptors or an antigen binding fragment thereof, a vector comprising the nucleic acid, and a host cell comprising the vector. Further provided is a method for preparing a specific T cell receptor for a KRAS G12V mutation or an antigen-binding fragment thereof. The specific T cell receptor and antigen-binding fragment thereof can be used as an immune activator to stimulate an immune response of an organism, thereby generating an effect against tumors and other diseases.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: Provided herein are recombinant antibodies, antigen-binding fragments thereof, and fusion proteins thereof useful for binding to and inhibiting B7-H4. Also provided are nucleic acid molecules encoding the antibodies, antigen-binding fragments thereof, and fusion proteins thereof disclosed herein and therapeutic compositions thereof. Disclosed are further methods of using the disclosed antibodies, antigen-binding fragments thereof, and fusion proteins thereof for the treatment of disease.

Abstract: A method and system for modeling, simulating, and optimizing a FinFET device based on self-heating effect are provided. The method includes: building and electrically simulating a FinFET device model based on general data through simulation software; thermally simulating the FinFET device model to obtain a thermal parameter; modifying a simulated ambient temperature according to the thermal parameter and modifying the electrical characteristic parameter of the FinFET device model in an environment where a FinFET device is affected by self-heating; and finally building the FinFET device model based on self-heating effect. The method and system for modeling, simulating, and optimizing the FinFET device based on self-heating effect in disclosure provides lowered errors of device simulation, improved modeling precision, and enhanced accuracy of reliability analyses when being compared with conventional modeling without considering the self-heating effect.

Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.

Abstract: For a distributed and decentralized blockchain system using state function driven consensus protocol, the identity of the network node that is selected for building the next block is publicly known since it is determined by the blockchain state function at the current blockchain state. An administrator proxy contract protocol is proposed and implemented to protect the identity of the actual builder of the next block until the block is built and synchronized across the blockchain network. A notion of blockchain clock and a method to construct such a clock are introduced to replace computer system clock as a synchronized measure of blockchain state progression. A secured form of the blockchain state function is constructed based on the administrator proxy contract protocol and is used to against any blockchain state manipulation attempts by an adversary.

Abstract: Magic cube speaker with charging stand, charging block, and methods for controlling the same, comprising a magic cube module having a liner with a cavity inside and splicing blocks installed on surface of the liner, a speaker inside the cavity, a charging interface, and a button mounted to the splicing block. The splicing block comprises sound passages formed by a sound inlet port, a sound outlet port, and a middle section between the sound inlet and outlet ports. A first sound transmission channel is formed by the cavity inside the liner, the sound transmission holes, the sound inlet port, the hollow space inside the splicing block, and the sound outlet port, and a second sound transmission channel is formed by the cavity inside the liner, the sound transmission holes, the sound inlet port, the hollow space inside the splicing block, and the plurality of the micro holes.

Abstract: A method of forming a high temperature sensor includes preparing a substrate having a surface from an electrically insulative material having a first coefficient of thermal expansion (CTE), preparing an electrical conductor from a metal material having a second CTE that is different from the first CTE, and creating an interface between the electrical conductor and the substrate with a CTE blending medium that is provided between the substrate and the electrical conductor. The CTE blending medium accommodates differing thermal expansion rates of the substrate and the electrical conductor at temperatures of at least 700° C.

Abstract: The present disclosure relates to a memory test system and a memory test method. The memory test system comprises: a plurality of test devices, a host computer, and driving modules. Each of the test devices is provided with a test interface used for connecting a memory to be tested. The host computer is respectively connected to the plurality of test devices and configured to control the test devices to test the memory to be tested. The driving modules are connected to the test devices and configured to output, to the test devices, driving signals used for driving the test devices to perform data interaction with the host computer.

Abstract: A method of forming a high temperature sensor includes preparing a substrate having a surface from an electrically insulative material having a first coefficient of thermal expansion (CTE), preparing an electrical conductor from a metal material having a second CTE that is different from the first CTE, and creating an interface between the electrical conductor and the substrate with a CTE blending medium that is provided between the substrate and the electrical conductor. The CTE blending medium accommodates differing thermal expansion rates of the substrate and the electrical conductor at temperatures of at least 700° C.