Abstract: Methods and compositions are provided for producing nucleic acid-based compositions. Methods include enzyme catalyzed or nucleic acid polymer conjugation. Compositions include nucleic acid-containing hydrogels which can be elongated via rolling circle amplification. The hydrogels can encapsulate bioactive agents for drug delivery.

Abstract: Compositions and methods are provided for constructing multi-functional nucleic acid nano-structures. Nano-structures are provided incorporating a built-in modularity, including nucleic acid modules. Modules contain moieties including detectible labels, nanoparticles, reactive moieties and other functional groups. Nano-structures can be used for delivery of target compounds, as well as identification of target nucleic acid molecules.

Abstract: Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. The nucleic acids are used to form dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds in biomedical and biotechnological applications. In particular, the macromolecules may be used for the delivery of drugs, genetic material, imaging components or other functional molecule to which they can be conjugated. An additional feature of the macromolecules is their ability to be targeted for certain organs, tumors, or types of tissues. Methods of utilizing such biomaterials include delivery of functional molecules to cells.

Abstract: The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further related to the use of DNA as building block for DNA-materials that are of high yield and purity and that can be incorporated into larger structures.

Abstract: Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.

Abstract: The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further relates to the use of DNA as a bulding block for DNA-materials that are of high yield and purity and that can be incorporated into larger structures.

Abstract: This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.

Abstract: Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.

Abstract: The invention is directed to a detection molecule for detection of a target molecule. The detection molecule includes a probe specific to the target molecule. One or more multimer nucleic acid molecules are connected to the probe, whereby the multimer is also coupled to at least one detectable label. The detection molecules are utilized in a method to detect the presence of one or more target molecules in a sample.

Abstract: A portable key assembly occupies less space and is attachable to certain attachment structures for providing a key-turning moment arm. The portable key assembly is set with a key body, a lock fastener, and an abbreviated key handle on one end of the key body. The portable key assembly can be connected and overlapped in face-to-face relation with other keys or key accessories so that the same may be well combined, easily located, and convenient to carry. A moment arm extension can be formed by connecting the portable key assembly with other keys or key accessories. The turning torque of the key handle may thus be enlarged so that the portable key assembly can function properly even if the key handle is shortened and the volume of the whole key is reduced.

Abstract: This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.

Abstract: One aspect of the present invention relates to a nucleic acid delivery system including a polymeric structure formed of a biocompatible polymer and a mixture comprising one or more nucleic acid molecules and a first co-dispersant, the mixture being contained within the polymeric structure, wherein the first co-dispersant is present in an amount effective to control diffusion of the one or more nucleic acid from the polymeric structure. Compositions including the nucleic acid delivery system and a pharmaceutically-acceptable carrier are disclosed. Methods of making the nucleic acid delivery system and their use in delivering nucleic acid into a patient and modifying gene expression in a target cell are also disclosed.

Abstract: The present invention relates to the design and use of nucleic acid molecules to create novel materials.

Abstract: This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.

Abstract: Compositions are disclosed comprising complexes of polynucleotide molecules which are covalently coupled to ligand moieties that are specifically bound to ligand-binding molecules, where the ligand binding molecules have multiple ligand-binding sites that specifically bind to the ligand moieties. Each polynucleotide molecule in these complexes is covalently coupled to at least one ligand moiety which is specifically bound to a ligand-binding site on a ligand-binding molecule. Most or all of the ligand-binding molecules in the complexes are linked to multiple polynucleotide molecules by specific binding to multiple ligand moieties; and most or all of the polynucleotide molecules in the compositions are included in these complexes. Also disclosed are methods for preparing compositions of the invention and for using them to introduce polynucleotides into cells, including for expressing genes for gene therapy.

Abstract: The present invention provides a method for enhancing the delivery of nucleic acid molecules to cells by increasing the concentration of cells at the cell surface. The method comprises the step of premixing of nucleic acid:vector molecules with nanoparticles that are biocompatible, reversibly associate with the nucleic acids and have a sedimentation rate which increases the concentration of the nucleic acids at the cell surface so as to enhance delivery into the cells.

Abstract: The present invention provides an economical and efficient means for removing grease and other contaminants from restaurant wastewater. There is a need for an easily removable drain filter. The present invention meets this need, as it is a low-cost, disposable, and efficient means for removing these contaminants.