Patents by Inventor Dan S. Kaufman

Dan S. Kaufman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NATURAL KILLER CELLS WITH ENHANCED ACTIVITY
    Publication number: 20240010980
    Abstract: Engineered immune cells, optionally natural killer (NK) cells, comprising an inactivating mutation for an endogenous A-Disintegrin-And-Metalloproteinase 17 (ADAM 17) gene. ADAM17-deficient immune cells produced from stem cells, optionally, induced pluripotent stem cells (iPSCs), having enhanced antibody-dependent cellular cytotoxicity (ADCC). Pharmaceutical compositions comprising said engineered immune cells. Methods for making the engineered immune cell and pharmaceutical compositions, and methods of use are provided.
    Type: Application
    Filed: October 27, 2021
    Publication date: January 11, 2024
    Inventors: Dan S. Kaufman, Kenta Yamamoto
  • CHMP2A as a Regulator of Natural Killer Cell-Mediated Activity
    Publication number: 20220154183
    Abstract: Methods and compositions for increasing tumor cell sensitivity to natural killer cell-mediated toxicity by inhibiting CHMP2A or other endosomal sorting complex required for transport in the tumor cell.
    Type: Application
    Filed: March 23, 2020
    Publication date: May 19, 2022
    Inventors: Dan S. Kaufman, Davide Bernareggi, Jeremy Rich, Qi Xie, Xiqing Li, Briana Prager
  • Switchable Chimeric Antigen Receptor-Engineered Human Natural Killer Cells
    Publication number: 20220152110
    Abstract: Engineered natural killer cells with switchable chimeric antigen receptor, methods of manufacture, pharmaceutical compositions, and methods of use in treating cancer and viral infection.
    Type: Application
    Filed: March 23, 2020
    Publication date: May 19, 2022
    Inventors: Dan S. Kaufman, Xiao-Hua Li, Eduardo Laborda, Travis Young
  • Method for developing natural killer cells from stem cells
    Patent number: 9260696
    Abstract: A method for producing NK cells from pluripotent stem cells, which includes culturing pluripotent stem cells in a first serum-free medium, aggregating the undifferentiated stem cells to form embryoid bodies, which are cultured to produce hematopoietic precursor cells, and culturing the precursor cells in a serum-free medium to produce the NK cells. Methods for using such NK cells, e.g., in the treatment of cancer and infectious disease are also provided.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: February 16, 2016
    Inventors: Dan S. Kaufman, David A. Knorr
  • METHOD FOR DEVELOPING NATURAL KILLER CELLS FROM STEM CELLS
    Publication number: 20130287751
    Abstract: A method for producing NK cells from pluripotent stem cells, which includes culturing pluripotent stem cells in a first serum-free medium, aggregating the undifferentiated stem cells to form embryoid bodies, which are cultured to produce hematopoietic precursor cells, and culturing the precursor cells in a serum-free medium to produce the NK cells. Methods for using such NK cells, e.g., in the treatment of cancer and infectious disease are also provided.
    Type: Application
    Filed: April 23, 2013
    Publication date: October 31, 2013
    Inventors: Dan S. KAUFMAN, David A. KNORR
  • Endothelial cells derived from primate embryonic stem cells
    Patent number: 7176023
    Abstract: A method is described to induce primate embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The ES derived endothelial cells have the general morphological and cell surface marker characteristics of endothelial cells. The ES derived endothelial cells also are capable of inducing and participating in blood vessel formation (or vascularization) when transplanted into tissue in vivo.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: February 13, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dan S. Kaufman, Rachel Lewis, Robert Auerbach
  • Hematopoietic differentiation of human embryonic stem cells
    Publication number: 20040043484
    Abstract: Disclosed herein are methods of obtaining human hematopoietic cells from human embryonic stem cells using mammalian stromal cells. Hematopoietic cells derived in this way are useful for creating cell cultures suitable for transplantation, transfusion, and other purposes.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 4, 2004
    Inventors: Dan S. Kaufman, James A. Thomson
  • Endothelial cells derived from primate embryonic stem cells
    Publication number: 20030166273
    Abstract: A method is described to induce primate embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The ES derived endothelial cells have the general morphological and cell surface marker characteristics of endothelial cells. The ES derived endothelial cells also are capable of inducing and participating in blood vessel formation (or vascularization) when transplanted into tissue in vivo.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 4, 2003
    Inventors: Dan S. Kaufman, Rachel Lewis, Robert Auerbach
  • Hematopoietic differentiation of human embryonic stem cells
    Patent number: 6613568
    Abstract: Disclosed herein are methods of obtaining human hematopoietic cells from human embryonic stem cells using mammalian stromal cells. Hematopoietic cells derived in this way are useful for creating cell cultures suitable for transplantation, transfusion, and other purposes.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: September 2, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dan S. Kaufman, James A. Thomson
  • Hematopoietic differentiation of human embryonic stem cells
    Publication number: 20020015694
    Abstract: Disclosed herein are methods of obtaining human hematopoietic cells from human embryonic stem cells using mammalian stromal cells. Hematopoietic cells derived in this way are useful for creating cell cultures suitable for transplantation, transfusion, and other purposes.
    Type: Application
    Filed: August 27, 2001
    Publication date: February 7, 2002
    Inventors: Dan S. Kaufman, James A. Thomson
  • Hematopoietic differentiation of human pluripotent embryonic stem cells
    Patent number: 6280718
    Abstract: Disclosed herein are methods of obtaining human hematopoietic cells from human pluripotent embryonic stem cells using mammalian stromal cells. Hematopoietic cells derived in this way are useful for creating cell cultures suitable for transplantation, transfusion, and other purposes.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: August 28, 2001
    Assignee: Wisconsin Alumni Reasearch Foundation
    Inventors: Dan S. Kaufman, James A. Thomson