Abstract: The present disclosure is directed to a pedal assembly that includes a pedal arm configured to move based on a load applied thereon and a housing that includes a first housing member having a first cavity and a pushrod operably connected to the pedal arm and to the first housing member. A first cradle positioned within the first cavity. The first cradle includes a second cavity. A first pair of springs positioned to extend within the second cavity. A second housing member having a third cavity. A second pair of springs positioned to extend within the second cavity and the third cavity. When a first predetermined load is applied to the pedal arm, the pushrod moves which drives the first cradle against the first pair of springs such that at least a compression energy by the first pair of springs generates a first force feedback onto the pedal arm.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

Abstract: A fluid input manifold distributes injected fluid around the body of a bulb to cool the bulb below a threshold. The injected fluid also distributes heat more evenly along the surface of the bulb to reduce thermal stress. The fluid input manifold may comprise one or more airfoils to direct a substantially laminar fluid flow along the surface of the bulb or it may comprise a plurality of fluid injection nozzles oriented to produce a substantially laminar fluid flow. An output portion may be configured to facilitate fluid flow along the surface of the bulb by allowing injected fluid to easily escape after absorbing heat from the bulb or by applying negative pressure to actively draw injected fluid along the surface of the bulb and away.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

Abstract: A cooling device and a cooled electronic assembly having a substrate having a first coefficient of thermal expansion, at least one heat source operably coupled to the substrate, a carrier plate operably coupled to the substrate and a heat sink wherein the heat sink, carrier plate, and substrate are configured to direct heat away from the at least one heat source.

Abstract: A system and method for automatically angularly positioning wheels of an automotive vehicle after parking. The system disclosed here includes a power-assisted steering system coupled to the wheels. Further, the system includes a controller, coupled to the steering system, which is configured to automatically position the wheels in a desired direction, based on a determination that the vehicle is parked.

Abstract: An apparatus for forming a wellbore in a formation may include a bit body and a sensor in the bit body. The sensor may include at least one cutting element and may be configured to generate information relating to a parameter of interest when the drill bit engages a wellbore surface.

Abstract: A Polycrystalline Diamond Compact (PDC) cutter for a rotary drill bit is provided with an integrated sensor and circuitry for making measurements of a property of a fluid in the borehole and/or an operating condition of the drill bit. A method of manufacture of the PDC cutter and the rotary drill bit is discussed.

Abstract: A fluid input manifold distributes injected fluid around the body of a bulb to cool the bulb below a threshold. The injected fluid also distributes heat more evenly along the surface of the bulb to reduce thermal stress. The fluid input manifold may comprise one or more airfoils to direct a substantially laminar fluid flow along the surface of the bulb or it may comprise a plurality of fluid injection nozzles oriented to produce a substantially laminar fluid flow. An output portion may be configured to facilitate fluid flow along the surface of the bulb by allowing injected fluid to easily escape after absorbing heat from the bulb or by applying negative pressure to actively draw injected fluid along the surface of the bulb and away.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

Abstract: A trailer connection assist system includes a towing vehicle having a hitch receiver, a trailer having a trailer hitch, a system controller, a position sensor provided on the hitch receiver and the trailer hitch and communicating with the system controller, a vehicle motor of the towing vehicle interfacing with the system controller, vehicle wheels of the towing vehicle interfacing with the vehicle motor and a steering system connected to the system controller and the vehicle wheels and adapted to steer the vehicle wheels. The system controller is adapted to operate the vehicle motor and the steering system responsive to input from the position sensor. A method of aligning a hitch with a hitch receiver provided on a towing vehicle is also disclosed.

Abstract: A system and method for automatically angularly positioning wheels of an automotive vehicle after parking. The system disclosed here includes a power-assisted steering system coupled to the wheels. Further, the system includes a controller, coupled to the steering system, which is configured to automatically position the wheels in a desired direction, based on a determination that the vehicle is parked.

Abstract: An apparatus for forming a wellbore in a formation may include a bit body and a sensor in the bit body. The sensor may include at least one cutting element and may be configured to generate information relating to a parameter of interest when the drill bit engages a wellbore surface.

Abstract: A Polycrystalline Diamond Compact (PDC) cutter for a rotary drill bit is provided with an integrated sensor and circuitry for making measurements of a property of a fluid in the borehole and/or an operating condition of the drill bit. A method of manufacture of the PDC cutter and the rotary drill bit is discussed.

Abstract: A trailer connection assist system includes a towing vehicle having a hitch receiver, a trailer having a trailer hitch, a system controller, a position sensor provided on the hitch receiver and the trailer hitch and communicating with the system controller, a vehicle motor of the towing vehicle interfacing with the system controller, vehicle wheels of the towing vehicle interfacing with the vehicle motor and a steering system connected to the system controller and the vehicle wheels and adapted to steer the vehicle wheels. The system controller is adapted to operate the vehicle motor and the steering system responsive to input from the position sensor. A method of aligning a hitch with a hitch receiver provided on a towing vehicle is also disclosed.

Abstract: The invention teaches the removal of unwanted features from an image, or the transformation of a region, by selectively expanding at least one region, and then selectively contracting the region. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: An audio/video (A/V) component networking system comprises a source component, a presentation device, and a sink component. The sink component is adapted to control presentation of A/V program data received from the source component on the presentation device. The sink component is also adapted to transmit a command to the source component to control display of an A/V menu data stream on the presentation device.

Abstract: An audio/video (A/V) component networking system comprises a plurality of source components each adapted to provide A/V program data. The system also comprises a presentation device adapted to present A/V program data to a user. The system further comprises a sink component communicatively coupled to each of the source components. The sink component is adapted to present to the user an aggregated listing of the A/V program data available from each of the plurality of source components to enable the user to select particular A/V program data from at least one of the plurality of source components for presentation on the presentation device.