Abstract: The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.

Abstract: The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.

Abstract: Systems, methods, computer program products, and kits involving deformation mechanisms are provided for the removal of corneal tissue in optical vision treatments. According to exemplary embodiments, deformation mechanisms may be used in combination with the administration of femtosecond photoalteration lasers to create or define volumetric tissue portions for such removal.

Abstract: Embodiments of the present invention encompass the manufacture of pre-cut lenses and the use of such lenses in combination with laser surgical techniques, including femtosecond laser photodisruption or photoalteration treatments. These techniques further expand the capabilities of lasers, and allow their use for both incising and refractively altering the eye. In many instances, embodiments disclosed herein are suitable for the treatment or correction of regular refractive errors and an irregular refractive alterations (such as correcting an irregular refractive error of the eye), without having to resort to two separate laser systems.

Abstract: Systems, methods, computer program products, and kits involving deformation mechanisms are provided for the removal of corneal tissue in optical vision treatments. According to exemplary embodiments, deformation mechanisms may be used in combination with the administration of femtosecond photoalteration lasers to create or define volumetric tissue portions for such removal.