Patents by Inventor Dan Zhou
Dan Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8927548Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: GrantFiled: January 13, 2012Date of Patent: January 6, 2015Assignee: Synta Pharmaceuticals Corp.Inventors: Weiwen Ying, David James, Shijie Zhang, Junghyun Chae, Teresa Kowalczyk-Przewloka, Howard P. Ng, Hao Li, Zachary Demko, Dinesh U. Chimmanamada, Chi-wan Lee, Zhenjian Du, Kevin Foley, Minghu Song, Lijun Sun, Keizo Koya, Dan Zhou, Shuzhen Qin
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Publication number: 20140380210Abstract: A method, system, and computer program product for human-machine interface devices. Embodiments commence upon receiving a set of dimensions, at least some of the dimensions having a plurality of dimension values, then generating for display, a first interactive user interface comprising a series of dimension tiles corresponding to the set of dimensions. A second interactive user interface comprising at least some of the dimensions is displayed in tandem such that a user interaction upon the first interactive user interface causes a change in the second interactive user interface. The dimension tiles can be used in configuration operations such that upon receiving a user interaction upon the dimension tiles, the change in configuration is reflected over the second interactive user interface.Type: ApplicationFiled: June 20, 2014Publication date: December 25, 2014Applicant: ORACLE INTERNATIONAL CORPORATIONInventors: Julia BLYUMEN, John CARTAN, Dan ZHOU
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Publication number: 20140371222Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: ApplicationFiled: August 29, 2014Publication date: December 18, 2014Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Kowalczyk-Prezewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Paul Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
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Patent number: 8892529Abstract: In embodiments of the present invention, when a duplicate data query is performed on a received data stream, a first physical node which corresponds to each first sketch value and is in a cluster system is identified according to a first sketch value representing the data stream, and then the first sketch value representing the data stream is sent to the identified physical node for the duplicate data query, and a procedure of the duplicate data query does not change with an increase of the number of nodes in the cluster system; therefore, a calculation amount of each node does not increase with an increase of the number of nodes in the cluster system.Type: GrantFiled: December 24, 2013Date of Patent: November 18, 2014Assignee: Huawei Technologies Co., Ltd.Inventors: Qiang Liu, Quancheng Sun, Xiaobo Liu, Jun You, Huadi Yang, Dan Zhou, Yan Huang
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Patent number: 8835464Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: GrantFiled: April 5, 2013Date of Patent: September 16, 2014Assignee: Synta Pharmaceuticals Corp.Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Kowalczyk-Prezewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Paul Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
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Patent number: 8827572Abstract: A side-coupling optical fiber assembly comprises a first substrate (200), on a surface of which at least one concave groove is provided; an optical fiber (210) disposed in the concave groove; and a second substrate (220) disposed on the first substrate (200) and pressed on the optical fiber (210). The end of the optical fiber (210) between the first substrate (200) and the second substrate (220) is set as a slant surface (240), which is used for performing total reflection for the light beam transmitted in the optical fiber (210). A method for making the side-coupling optical fiber assembly is provided.Type: GrantFiled: February 4, 2010Date of Patent: September 9, 2014Assignee: Wuhan Telecommunication Devices Co., Ltd.Inventor: Dan Zhou
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Publication number: 20140201169Abstract: In embodiments of the present invention, when a duplicate data query is performed on a received data stream, a first physical node which corresponds to each first sketch value and is in a cluster system is identified according to a first sketch value representing the data stream, and then the first sketch value representing the data stream is sent to the identified physical node for the duplicate data query, and a procedure of the duplicate data query does not change with an increase of the number of nodes in the cluster system; therefore, a calculation amount of each node does not increase with an increase of the number of nodes in the cluster system.Type: ApplicationFiled: December 24, 2013Publication date: July 17, 2014Applicant: HUAWEI TECHNOLOGIES CO.,LTD.Inventors: Qiang LIU, Quancheng SUN, Xiaobo LIU, Jun YOU, Huadi YANG, Dan ZHOU, Yan HUANG
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Publication number: 20140141511Abstract: The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.Type: ApplicationFiled: October 16, 2013Publication date: May 22, 2014Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Dan Zhou, Shuzhen Qin, Weiwen Ying
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Publication number: 20140127740Abstract: Provided is a method of identifying Hsp90 inhibitors with substantially less ocular toxicity or with substantially improved ocular toxicity profile. The method comprises measuring the respective concentrations of an Hsp90 inhibitor in the retina and plasma at certain time points following the administration of the Hsp90 inhibitor in a subject, and determining the concentration ratio of the Hsp90 inhibitor between retina and plasma, where a certain ratio is indicative that the Hsp90 inhibitor has substantially less ocular toxicity. The method also includes identifying an Hsp90 inhibitor with substantially less ocular toxicity, or with a substantially improved ocular toxicity profile, by determining the elimination rate of the Hsp90 inhibitor from the retina following administration of the Hsp90 inhibitor, where a certain elimination rate is indicative that the Hsp90 inhibitor will induce substantially less ocular toxicity.Type: ApplicationFiled: January 10, 2014Publication date: May 8, 2014Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Dan Zhou, Takayo Inoue
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Patent number: 8628752Abstract: Provided is a method of identifying Hsp90 inhibitors with substantially less ocular toxicity or with substantially improved ocular toxicity profile. The method comprises measuring the respective concentrations of an Hsp90 inhibitor in the retina and plasma at certain time points following the administration of the Hsp90 inhibitor in a subject, and determining the concentration ratio of the Hsp90 inhibitor between retina and plasma, where a certain ratio is indicative that the Hsp90 inhibitor has substantially less ocular toxicity. The method also includes identifying an Hsp90 inhibitor with substantially less ocular toxicity, or with a substantially improved ocular toxicity profile, by determining the elimination rate of the Hsp90 inhibitor from the retina following administration of the Hsp90 inhibitor, where a certain elimination rate is indicative that the Hsp90 inhibitor will induce substantially less ocular toxicity.Type: GrantFiled: October 26, 2012Date of Patent: January 14, 2014Inventors: Dan Zhou, Takayo Inoue
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Publication number: 20130345219Abstract: The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.Type: ApplicationFiled: August 28, 2013Publication date: December 26, 2013Applicant: Synta Pharmaceuticals Corp.Inventors: Chi-Wan Lee, Teresa Prezewloka, Weiwen Ying, Minghu Song, Zhenjian Du, Kevin Foley, Dan Zhou, Shuzhen Qin
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Publication number: 20130296378Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: ApplicationFiled: April 5, 2013Publication date: November 7, 2013Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Prezewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Paul Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
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Patent number: 8524712Abstract: The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.Type: GrantFiled: March 24, 2008Date of Patent: September 3, 2013Assignee: Synta Pharmaceuticals Corp.Inventors: Chi-Wan Lee, Teresa Przewloka, Weiwen Ying, Minghu Song, Zhenjian Du, Kevin Foley, Dan Zhou, Shuzhen Qin
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Patent number: 8415377Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: GrantFiled: September 9, 2011Date of Patent: April 9, 2013Assignee: Synta Pharmaceuticals Corp.Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Przewloka, Shijie Zhang, Dinesh Chimmanamada, Kevin Foley, Zhenjian Du, Hao Li, David James, Howard Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
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Patent number: 8329736Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: GrantFiled: April 20, 2012Date of Patent: December 11, 2012Assignee: Synta Pharmaceuticals, Corp.Inventors: Dinesh U. Chimmanamada, Weiwen Ying, Teresa Kowalczyk Przewloka, Shijie Zhang, Kevin Foley, Zhenjian Du, Dan Zhou, Shuzhen Qin
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Publication number: 20120302888Abstract: This invention relates to a radial array ultrasound endoscopic probe and its manufacture method and a fixing and rotating device. The probe comprises: a metal cylinder located at the center; a plurality of piezoelectric elements which are cut from piezoelectric ceramic or single crystal rings and arranged around the metal cylinder, said piezoelectric elements and said metal cylinder being provided with a backing material layer for absorbing sound therebetween, said piezoelectric elements being covered with a matching material layer on the outer side thereof, and said piezoelectric elements are filled with decoupling material therebetween; a plurality of coaxial cables correspondingly connected with the plurality of piezoelectric elements; and a circular lattice in a gear shape which sleeves over said metal cylinder and functions to arrange and separate the coaxial cables.Type: ApplicationFiled: May 23, 2012Publication date: November 29, 2012Applicant: The Hong Kong Polytechnic UniversityInventors: Jiyan Dai, Kwok Fung Cheung, Dan Zhou, Yat Ching Chiu, Kwok Ho Lam, Yan Chen, Helen L. W. Chan
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Patent number: 8318790Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: GrantFiled: May 25, 2007Date of Patent: November 27, 2012Assignee: Synta Pharmaceuticals Corp.Inventors: Weiwen Ying, David James, Shijie Zhang, Junghyun Chae, Teresa Przewloka, Howard P. Ng, Hao Li, Zachary Demko, Dinesh U. Chimmanamada, Chi-wan Lee, Zhenjian Du, Kevin Foley, Minghu Song, Lijun Sun, Keizo Koya, Dan Zhou, Shuzhen Qin
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Publication number: 20120231542Abstract: Compositions and methods for culturing therapeutic cells are provided herein. According to at least one embodiment, compositions comprising cord blood plasma and lysed platelets and methods for making and using same are provided herein.Type: ApplicationFiled: March 12, 2012Publication date: September 13, 2012Applicant: GENERAL BIOTECHNOLOGY, LLCInventors: Erik J. Woods, Sreedhar Thirumala, Dan Zhou, W. Scott Goebel
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Publication number: 20120202813Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: ApplicationFiled: April 20, 2012Publication date: August 9, 2012Applicant: Synta Pharmaceuticals Corp.Inventors: Dinesh U. Chimmanamada, Weiwen Ying, Teresa Kowalczyk Przewloka, Shijie Zhang, Kevin Foley, Zhenjian Du, Dan Zhou, Shuzhen Qin
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Patent number: 8183384Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.Type: GrantFiled: May 25, 2007Date of Patent: May 22, 2012Assignee: Synta Pharmaceuticals Corp.Inventors: Dinesh U. Chimmanamada, Weiwen Ying, Teresa Przewloka, Shijie Zhang, Kevin Foley, Zhenjian Du, Dan Zhou, Shuzhen Qin