Patents by Inventor Daniëlle Anne Marie Heideman

Daniëlle Anne Marie Heideman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methylation classifier for detection of HPV-induced invasive cancers, nonHPV-induced gynaecological and anogenital cancers and their high-grade precursor lesions
    Patent number: 11932909
    Abstract: The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of a methylation classifier consisting of the genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the methylation classifier consisting of genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in such a method and a test kit for the detection of LHX8. ASCL1 and/or ST6GALNAC5 methylation.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: March 19, 2024
    Assignee: SELF-SCREEN B.V.
    Inventors: Christophorus Joannes Lambertus Maria Meijer, Renske Daniëla Maria Steenbergen, Petrus Josephus Ferdinandus Snijders, Daniëlle Anne Marie Heideman
  • METHYLATION CLASSIFIER FOR DETECTION OF HPV-INDUCED INVASIVE CANCERS, NONHPV-INDUCED GYNAECOLOGICAL AND ANOGENITAL CANCERS AND THEIR HIGH-GRADE PRECURSOR LESIONS
    Publication number: 20200032348
    Abstract: The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of a methylation classifier consisting of the genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the methylation classifier consisting of genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in such a method and a test kit for the detection of LHX8. ASCL1 and/or ST6GALNAC5 methylation.
    Type: Application
    Filed: March 9, 2018
    Publication date: January 30, 2020
    Inventors: Christophorus Joannes Lambertus Maria MEIJER, Renske Daniëla Maria STEENBERGEN, Petrus Josephus Ferdinandus SNIJDERS, Daniëlle Anne Marie HEIDEMAN
  • METHYLATION ANALYSIS ON SELF-SAMPLES AS TRIAGE TOOL FOR HPV-POSITIVE WOMEN
    Publication number: 20150225796
    Abstract: The inventors now have developed a (molecular) diagnostic assay based on detection of alterations in markers MAL and hsa-mi R124, in particular promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, within cell material obtained via self-sampling. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the hsa-mi R124 gene as marker for HPV-induced high-grade premalignant lesions, allowing early detection and a better treatment option for the individual patient.
    Type: Application
    Filed: September 13, 2012
    Publication date: August 13, 2015
    Applicant: Self-screen B.V.
    Inventors: Petrus Josephus Ferdinandus Snijders, Renske Daniëla Maria Steenbergen, Daniëlle Anne Marie Heideman, Christophorus Joannes Lambertus Maria Meijer
  • CERVICAL SCREENING ALGORITHMS
    Publication number: 20110171628
    Abstract: This invention describes new protocols for screening for cervical carcinomas or high-grade premalignant cervical lesions based on combinations of testing for the presence of high-risk HPV, HPV genotyping, marker analysis, and/or cytology. With these protocols the number of women that have to undergo follow-updiagnostic testing and/or clinical examinations will decrease. Further, the number of false positives and false negatives will decrease.
    Type: Application
    Filed: March 13, 2009
    Publication date: July 14, 2011
    Applicant: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg
    Inventors: Christophorus Joannes Lambertus Maria Meijer, Petrus Josephus Ferdinandus Snijders, Renske Daniëla Maria Steenbergen, Daniëlle Anne Marie Heideman