Abstract: The invention provides, for example, a novel compound having the general formula (I): or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.

Abstract: An electrostatic discharge (ESD) robust design for an input device such as a stylus is disclosed. The input device can include one or more components, such as one or more Schottky diodes, that can be damaged by ESD events. To reduce the likelihood of damage to sensitive components, the parasitic capacitance between sensitive conductive paths and reference ground paths of the input device that could otherwise provide electrostatic discharge paths can be reduced (arranging current limiting resistance at specific locations among sensitive components, creating physical separation between sensitive conductive paths and reference ground paths), shielding can be added to shield the sensitive electronics from ESD pulses, and high dielectric breakdown material can be added to prevent ESD pulse entry or exit of not otherwise protected circuit parts.

Abstract: The invention refers to a method for producing expanded polymer pellets, which comprises the following steps: melting a polymer comprising a polyamide; adding at least one blowing agent; expanding the melt through at least one die for producing an expanded polymer; and pelletizing the expanded polymer. The invention further concerns polymer pellets produced with the method as well as their use, e.g. for the production of cushioning elements for sports apparel, such as for producing soles or parts of soles of sports shoes. A further aspect of the invention concerns a method for the manufacture of molded components, comprising loading pellets of an expanded to polymer material into a mold, and connecting the pellets by providing heat energy, wherein the expanded polymer material of the pellets or beads comprises a chain extender. The molded components may be used in broad ranges of application.

Abstract: According to some embodiments, a method performed by a classification scanner comprises receiving an electronic message and determining a classification that applies to the electronic message. The classification is determined based on an express indication from a user. The method further comprises providing a machine learning trainer with the electronic message and an identification of the classification that applies to the electronic message. The machine learning trainer is adapted to determine a machine learning policy that associates attributes of the electronic message with the classification.

Abstract: There is a method of computing a stylized, animatable representation of a subject from a family of stylized animatable representations. The method comprises: accessing a realistic representation of the subject; computing a mesh mapping using a model that was formed using a data set of training examples which pair realistic representations of other subjects with instances of the family. The method also comprises applying the mesh mapping to the realistic representation of the subject to produce a target mesh; and selecting the stylized animatable representation from the family, by assessing closeness of the target mesh with instances of the family.

Abstract: A method for determining the thickness of a plurality of coating layers. The method comprises the steps of performing a calibration analysis on calibration data to determine initial values and search limits of optical parameters of the plurality of coating layers, irradiating the plurality of layers with a pulse of THz radiation in the range from 0.01 THz to 10 THz, detecting the reflected radiation to produce a sample response derived from the reflected radiation, producing a synthesized waveform using the optical parameters and predetermined initial thicknesses of the layers, varying the thicknesses and the optical parameters within the search limits to minimize the error measured between the sample response and the synthesized waveform, and outputting the thicknesses of the layers.

Abstract: A system and method for operating an analgesia administration system is disclosed. A control device is associated with a drug delivery device and configured to receive a first user input including at least a portion of a fingerprint of a patient, together with a second user input corresponding to a request to administer medication. The portion of the fingerprint is compared with previously-stored fingerprints to determine an identity of the patient and, in response to receiving the second user input and determining that the patient is an authorized user, one or more sensors are used to obtain one or more signals indicative of a state of the patient. If the state of the patient satisfies a set of medication delivery criteria, the drug delivery device is caused to administer a predefined amount of medication to the patient.

Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: A cutting and harvesting assembly for an agricultural machine includes a structural frame. A feed roller is operably coupled with the structural frame. A deflector assembly is operably coupled with the structural frame. The deflector assembly includes a deflector plate at least partially laterally outward of the feed roller. The deflector plate is rotatable between a first position and a second position relative to the structural frame.

Abstract: User identities can managed at an organization level, instead of across multiple individual resource accounts. In a resource provider environment, access to various resources and services may require users to have identities with specific resource accounts. Users can instead be associated with organization accounts, or virtual accounts that are not associated with specific resources or services. The organization accounts are attached at the appropriate location(s) in an organizational hierarchy. A user having an organization account can project the identity in any sub-account in the organization hierarchy. This can include any lower-level resource account, or can child accounts under a relevant branch of the hierarchy. A user can validate against the organization account, and receive access to the relevant service or resources using the identity projected in the corresponding resource account.

Abstract: Preventing freezing in a heat exchanger can include passing first and second cooling fluids through the heat exchanger, monitoring a temperature and/or pressure of the second cooling fluid entering the heat exchanger, heating the second cooling fluid entering the heat exchanger by opening a valve when the monitored temperature and/or monitored pressure is below a trigger temperature and/or trigger pressure, and closing the valve when a condition is met. The first cooling fluid can have a first freezing temperature and the second cooling fluid can have a second, lower freezing temperature. Opening the valve can cause the second cooling fluid, in gaseous phase, to mix with the second cooling fluid, in liquid phase, upstream of the heat exchanger.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: A wing structure having a unitary body formed by a plurality of tubular sections that are arranged side-by-side and configured such that adjacent internal walls of the tubular sections create internal spar structures that substantially reduce or eliminate the need for non-integral spars, or for fasteners to attach conventional spars and ribs into the wing skins. The unitized structure formed by the plurality of tubular sections can be further overwrapped with a composite material to provide additional strength to the wing structure.

Abstract: The updating of a definition layer or schema for a large distributed database can be accomplished using a plurality of data store tiers. A distributed database can be made up of many individual data stores, and these data stores can be allocated across a set of tiers based on business logic or other allocation criteria. The update can be applied sequentially to the individual tiers, such that only data stores for a single tier are being updated at any given time. This can help to minimize downtime for the database as a whole, and can help to minimize problems that may result from an unsuccessful update. Such an approach can also allow for simplified error detection and rollback, as well as providing control over a rate at which the update is applied to the various data stores of the distributed database.

Abstract: According to some embodiments, a method performed by a classification scanner comprises receiving an electronic message and determining a classification that applies to the electronic message. The classification is determined based on an express indication from a user. The method further comprises providing a machine learning trainer with the electronic message and an identification of the classification that applies to the electronic message. The machine learning trainer is adapted to determine a machine learning policy that associates attributes of the electronic message with the classification.

Abstract: Described implementations obtain credential information including an encrypted digital identity (ID). The encrypted digital ID may include a public component of a credential and identity data. Furthermore, the credential information may include cryptographically obfuscated data based on the identity data and a private component of the credential. A proof is obtained that includes proof data. The proof data may confirm that the credential information was correctly generated. Verification of the proof data, and confirmation that the cryptographically obfuscated data is not associated in a collection of cryptographically obfuscated data, cause a computer-implemented service to issue a pseudonym. The pseudonym is usable to generate a relationship associated with a computer-implemented service.

Abstract: A cutting and harvesting assembly for an agricultural machine includes a structural frame. A central portion divider set is operably coupled with the structural frame and includes one or more central portion feed rollers. A first line divider set is laterally offset from the central portion divider set. The first line divider set includes a first pivoting frame, a first connection element operably coupled to the first pivoting frame and the structural frame, one or more first set feed rollers operably coupled with the first pivoting frame. A second line divider set is positioned on an opposing side of the central portion divider set from the first line divider set. The second line divider set includes a second pivoting frame, a second connection element operably coupled to the second pivoting frame and the structural frame, and one or more second set feed rollers operably coupled with the second pivoting frame.

Abstract: According to some embodiments, a method performed by a classification scanner comprises receiving an electronic message and determining whether the electronic message includes an express indication from the user indicating that a classification applies to the electronic message. In response to determining that the electronic message does not include the express indication that the classification applies to the electronic message, the message further comprises sending the electronic message to a machine learning scanner. The machine learning scanner is adapted to use a machine learning policy to determine whether the classification applies to the electronic message.

Abstract: A method and apparatus for testing and simulating an access control policy are disclosed. Evaluating an access control policy may be performed by utilizing a deny statement that causes the access request to be rejected despite actions indicated in the access request being authorized. Further, an independent simulation environment may be utilized for testing access control policy evaluation.

Abstract: Visual content of media programs is recognized using text-based scripts of the media programs. A script of a media program includes sets of words to be spoken by actors during the media program, and also descriptions of points of interest of the media program. A file of subtitles or captions of a media program includes sets of words actually spoken by actors during the media program along with marks or stamps of times when such words were spoken. The sets of words of a script and in subtitles or captions are processed to determine where such words align. The sets of words of the script are then marked or stamped with times from the subtitles. The descriptions may then be processed to predict the visual content from such descriptions, and times at which the visual content appears within the media program are determined from the sets of words.