Patents by Inventor Daniel Bratton
Daniel Bratton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230357846Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: May 26, 2023Publication date: November 9, 2023Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 11702694Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: March 1, 2021Date of Patent: July 18, 2023Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Publication number: 20220073907Abstract: Described is a method for screening an encoded chemical library, which library comprises a plurality of different chemical structures each releasably linked to an encoding tag, the method comprising the steps of: (a) providing said library of tagged chemical structures; (b) releasing each chemical structure from its tag to produce a plurality of free, tagless chemical structures (TCSs); (c) screening the TCSs by contacting them with a assay system under conditions whereby a spatial association between each TCS and its tag is maintained, to produce a plurality of different screened TCSs each spatially associated with its tag; and (d) identifying a screened TCS by decoding a tag that is spatially associated therewith.Type: ApplicationFiled: November 29, 2021Publication date: March 10, 2022Applicant: NANNA THERAPEUTICS LIMITEDInventors: David Hugh WILLIAMS, Ipshita MANDAL, Stuart Robert WOOD, Daniel BRATTON
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Publication number: 20210254151Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: March 1, 2021Publication date: August 19, 2021Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 10954561Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: April 10, 2019Date of Patent: March 23, 2021Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Publication number: 20190264199Abstract: Described is a method for screening an encoded chemical library, which library comprises a plurality of different chemical structures each releasably linked to an encoding tag, the method comprising the steps of: (a) providing said library of tagged chemical structures; (b) releasing each chemical structure from its tag to produce a plurality of free, tagless chemical structures (TCSs); (c) screening the TCSs by contacting them with a assay system under conditions whereby a spatial association between each TCS and its tag is maintained, to produce a plurality of different screened TCSs each spatially associated with its tag; and (d) identifying a screened TCS by decoding a tag that is spatially associated therewith.Type: ApplicationFiled: November 8, 2017Publication date: August 29, 2019Applicant: NANNA THERAPEUTICS LIMITEDInventors: David Hugh WILLIAMS, Ipshita MANDAL, Stuart Robert WOOD, Daniel BRATTON
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Publication number: 20190233890Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
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Patent number: 10266891Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: August 18, 2017Date of Patent: April 23, 2019Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan C. Smith
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Publication number: 20170342487Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: August 18, 2017Publication date: November 30, 2017Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan C. Smith
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Patent number: 9752186Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: April 6, 2015Date of Patent: September 5, 2017Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan C. Smith
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Publication number: 20150259735Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: April 6, 2015Publication date: September 17, 2015Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan C. Smith
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Patent number: 9012022Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: GrantFiled: March 4, 2013Date of Patent: April 21, 2015Assignee: Illumina, Inc.Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan C. Smith
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Patent number: 8828210Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).Type: GrantFiled: October 16, 2008Date of Patent: September 9, 2014Assignee: Cambridge Enterprise LimitedInventors: Chris Abell, Wilhelm T. S. Huck, Daniel Bratton, Graeme Whyte, Luis M. Fidalgo
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Publication number: 20140079923Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.Type: ApplicationFiled: March 4, 2013Publication date: March 20, 2014Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan C. Smith
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Publication number: 20120091004Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).Type: ApplicationFiled: October 16, 2008Publication date: April 19, 2012Inventors: Chris Abell, Wilhelm T.S. Huck, Daniel Bratton, Graeme Whyte, Luis M. Fidalgo