Abstract: The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: Methods and apparatus for processing a substrate using plasma are disclosed. The apparatus includes a plasma processing system having a process gas supply arrangement for supplying a process gas into an interior region of said chamber and a plasma source configured for generating said plasma at least from said process gas. The apparatus also includes an acoustic energy generator arrangement configured to apply acoustic energy to at least one of a chamber component and said substrate, wherein said acoustic energy generator generates said acoustic energy in the range of 10 Hz to 1 MHz using at least one of a piezoelectric transducing, mechanical coupling vibration, wafer backside gas pulsing, pulsing of said process gas, pressure wave pulsing, and electromagnetic coupling.

Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Abstract: The movement of a Virtual IP (VIP) address from cluster node to cluster node is coordinated via a load balancer. All or a subset of the nodes in a load balancer cluster may be configured as possible hosts for the VIP. The load balancer directs VIP traffic to the Dedicated IP (DIP) address for the cluster node that responds affirmatively to periodic health probe messages. In this way, a VIP failover is executed when a first node stops responding to probe messages, and a second node starts to respond to the periodic health probe messages. In response to an affirmative probe response from a new node, the load balancer immediately directs the VIP traffic to the new node's DIP. The probe messages may be configured to identify which nodes are currently responding affirmatively to probes to assist the nodes in determining when to execute a failover.

Abstract: The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I):(I) or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to 5 compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I):10 X NH O S O O R1 R2 R5 R4 R3 Het1 (I) or a pharmaceutically acceptable salt thereof, wherein X, Het1, R1, R2, R3, R4 and R5 are as defined in the description. 15 Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfon-amide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: A catheter having shaft segments which are joined together by a strong bond providing a low profile shaft section with a flexibility transition and/or a compositional transition. A balloon catheter embodying features of the invention has a distal tip member and a coupling band member surrounding a junction of an inner tubular member of the shaft, and has a gradual change in bending stiffness along a distal end section of the shaft which extends distally from a location within the balloon interior. Another catheter embodying features of the invention has shaft segments joined together by a diagonal seam.

Abstract: During generation of a signature on a message to create a signed message, a signer determines one of the signature components such that particular information can be extracted from the signature component. The particular information may be related to one or more of the signer and the message to be signed. After receiving a signed message purported to be signed by the signer, a verifier can extract the particular information from the signature component.

Abstract: During generation of an implicit certificate for a requestor, a certificate authority incorporates information in the public-key reconstruction data, where the public-key reconstruction data is to be used to compute the public key of the requestor. The information may be related to one or more of the requestor, the certificate authority, and the implicit certificate. The certificate authority reversibly encodes the public-key reconstruction data in the implicit certificate and sends it to the requestor. After receiving the implicit certificate from the certificate authority, the requestor can extract the incorporated information from the public-key reconstruction data. The implicit certificate can be made available to a recipient, and the recipient can also extract the incorporated information.

Abstract: An aspect of the disclosed subject matter includes a method of reducing the laser absorption of a beam reverser prism consisting of at least one of the following: increasing a first distance between a first incident point and a chamfered corner, wherein the first incident point is on a first reflective surface of the prism and the chamfered corner is formed between the first reflective surface and a second reflective surface of the prism, wherein the chamfered corner has a chamfered surface; increasing a second distance between a second incident point and the chamfered corner, wherein the second incident point is on the second reflective surface of the prism; and increasing a reflectivity of the chamfered surface of the chamfered corner of the prism. A method of determining a prime cut for an optical component is also disclosed. A laser including at least one prime cut optical component is also disclosed.

Abstract: A catheter having shaft segments which are joined together by a strong bond providing a low profile shaft section with a flexibility transition and/or a compositional transition. A balloon catheter embodying features of the invention has a distal tip member and a coupling band member surrounding a junction of an inner tubular member of the shaft, and has a gradual change in bending stiffness along a distal end section of the shaft which extends distally from a location within the balloon interior. Another catheter embodying features of the invention has shaft segments joined together by a diagonal seam.

Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Abstract: An aspect of the disclosed subject matter includes a method of reducing the laser absorption of a beam reverser prism consisting of at least one of the following: increasing a first distance between a first incident point and a chamfered corner, wherein the first incident point is on a first reflective surface of the prism and the chamfered corner is formed between the first reflective surface and a second reflective surface of the prism, wherein the chamfered corner has a chamfered surface; increasing a second distance between a second incident point and the chamfered corner, wherein the second incident point is on the second reflective surface of the prism; and increasing a reflectivity of the chamfered surface of the chamfered corner of the prism. A method of determining a prime cut for an optical component is also disclosed. A laser including at least one prime cut optical component is also disclosed.

Abstract: Embodiments allow access to geographic data objects on a per-object basis. A client may send a plurality of requests for geographic data to display within a view frustum. Map data may include a layer with a plurality of assets. Each request may be authenticated by an access control filter, which determines whether the user is authorized to view the data requested.

Abstract: A printing apparatus for printing within a predefined print zone on a selected surface of a skewed object moving in a given direction of travel includes a bracket, at least two sensors at known positions adjacent to the passing object detecting the leading edge of a given surface, a positioning mechanism mounted on the bracket, a printhead mounted on the positioning mechanism and operable to print on the moving object selected surface, the positioning mechanism operable to position the printhead into a known correct printing position relative to the selected surface, and a controller communicating with the sensors, positioning mechanism, and printhead, and operable to calculate object skew in response to the sensor signals and to operate the positioning mechanism to position the printhead into the known correct printing position and to operate the printhead to print within the predefined print zone on the skewed moving object.

Abstract: An apparatus and method for determining optimized path traversal in a radiation delivery system is described. In one embodiment, determining an optimized path traversal in a radiation delivery system involves providing a plurality of spatial nodes used in a treatment plan, where each of the plurality of spatial nodes represents a position of a radiation source made available to the treatment plan for delivering radiation to a target, identifying a number of unused spatial nodes, from among the plurality of spatial nodes, at which radiation is not delivered according to the treatment plan, and skipping travel to one or more of the unused nodes by the radiation source when administering the treatment plan. Other embodiments are also described.

Abstract: The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.