Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: A filter cartridge and filter assembly using the filter cartridge is provided. The filter cartridge having a contoured end member to angularly orient and/or axially orient the filter cartridge, and particularly a seal thereof, relative to a filter housing. The filter housing is reconfigurable to allow it to be used in different locations having different spatial configurations.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: A filter element includes a filter media having opposite first and second faces, and an outer face extending in a longitudinal direction perpendicular from the first face to the second face. An undulating sealing element is directly bonded to the outer face at a location closer to and offset from the first face. The undulations of the sealing element define an offset region of the outer face of the filter media from the first face, the offset region being defined by an amplitude of the undulations. The filter element may be incorporated into a filter assembly including the filter element enclosed by a filter housing. The sealing element may be made of urethane and be compressible within a mating groove in the filter housing.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: A filter cartridge and filter assembly using the filter cartridge is provided. The filter cartridge having a contoured end member to angularly orient and/or axially orient the filter cartridge, and particularly a seal thereof, relative to a filter housing. The filter housing is reconfigurable to allow it to be used in different locations having different spatial configurations.

Abstract: A filter element includes a filter media having opposite first and second faces, and an outer face extending in a longitudinal direction perpendicular from the first face to the second face. An undulating sealing element is directly bonded to the outer face at a location closer to and offset from the first face. The undulations of the sealing element define an offset region of the outer face of the filter media from the first face, the offset region being defined by an amplitude of the undulations. The filter element may be incorporated into a filter assembly including the filter element enclosed by a filter housing. The sealing element may be made of urethane and be compressible within a mating groove in the filter housing.

Abstract: Provided is a filter that filters air flowing from the filter to a downstream component, while preventing fluid from flowing from the filter to the downstream component and preventing a substance, such as urea or fuel, entering the filter from the downstream component from degrading the filter element in the filter. The filter includes a filter element having an interior surface defining an inner chamber and a standpipe extending through the inner chamber and terminating at a point that allows air that flows from outside the filter element through the filter element and into the inner chamber to flow into the standpipe and out of the filter, while preventing fluid flowing from the opposite direction through the standpipe from entering the filter element.

Abstract: A separator has a first inlet arranged to receive a fluid stream, and first and second separation stages coupled together in series; A pump coupled to the second separation stage generates an area of reduced pressure to draw the fluid stream through the first and second separation stages. One of the stages includes a variable impactor separator comprising a first chamber arranged to receive the fluid stream, and a second chamber coupled to the first chamber through an aperture to accelerate the first fluid stream. The stream is incident upon an impaction surface to separate contaminants from the fluid stream. An actuator adjusts the open area of the aperture according to a pressure differential between fluid pressure in the first chamber and a reference fluid pressure in a third chamber. The other of the separation stages is a second variable impactor separator or a filter media.

Abstract: Provided is a filter that filters air flowing from the filter to a downstream component, while preventing fluid from flowing from the filter to the downstream component and preventing a substance, such as urea or fuel, entering the filter from the downstream component from degrading the filter element in the filter. The filter includes a filter element having an interior surface defining an inner chamber and a standpipe extending through the inner chamber and terminating at a point that allows air that flows from outside the filter element through the filter element and into the inner chamber to flow into the standpipe and out of the filter, while preventing fluid flowing from the opposite direction through the standpipe from entering the filter element.

Abstract: A separator has a first inlet arranged to receive a fluid stream, and first and second separation stages coupled together in series; A pump coupled to the second separation stage generates an area of reduced pressure to draw the fluid stream through the first and second separation stages. One of the stages includes a variable impactor separator comprising a first chamber arranged to receive the fluid stream, and a second chamber coupled to the first chamber through an aperture to accelerate the first fluid stream. The stream is incident upon an impaction surface to separate contaminants from the fluid stream. An actuator adjusts the open area of the aperture according to a pressure differential between fluid pressure in the first chamber and a reference fluid pressure in a third chamber. The other of the separation stages is a second variable impactor separator or a filter media.

Abstract: A regulator (108) comprising a first chamber (132), and second chamber (134) and an actuator (130). The second chamber (134) is coupled to the first chamber (132) through an aperture (156). The actuator (130) is arranged to the adjust the size of the aperture (156) according to a pressure differential between fluid pressure in the first chamber (132) and a pressure reference (36). The rate of change of the cross sectional area of the aperture (156) is arranged to have a non-linear response to a change in the pressure differential.

Abstract: A regulator (108) comprising a first chamber (132), and second chamber (134) and an actuator (130). The second chamber (134) is coupled to the first chamber (132) through an aperture (156). The actuator (130) is arranged to the adjust the size of the aperture (156) according to a pressure differential between fluid pressure in the first chamber (132) and a pressure reference (36). The rate of change of the cross sectional area of the aperture (156) is arranged to have a non-linear response to a change in the pressure differential.