Patents by Inventor Daniel D. Carson

Daniel D. Carson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR REPAIR OF TISSUES
    Publication number: 20110082081
    Abstract: Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and a growth factor, and, optionally, collagen.
    Type: Application
    Filed: October 12, 2010
    Publication date: April 7, 2011
    Applicant: University of Delaware
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Weidong (William) Yang
  • Bioactive peptide for cell adhesion
    Patent number: 7897727
    Abstract: Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: March 1, 2011
    Assignee: University of Delaware
    Inventors: Mary C. Farach-Carson, Daniel D. Carson, Jeffrey B. Safran
  • Delivery system for heparin-binding growth factors
    Patent number: 7875591
    Abstract: A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce replication and/or differentiation of connective tissue cells and to repair tissue.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: January 25, 2011
    Assignee: University of Delaware
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Margaret French, Ronald Gomes
  • Bioactive peptide for cell adhesion
    Patent number: 7803905
    Abstract: The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scaffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: September 28, 2010
    Assignee: University of Delaware
    Inventors: Mary C. Farach-Carson, Daniel D. Carson, Jeffrey B. Safran
  • Delivery System For Heparin-Binding Growth Factors
    Publication number: 20100221302
    Abstract: A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce replication and/or differentiation of connective tissue cells and to repair tissue.
    Type: Application
    Filed: April 22, 2009
    Publication date: September 2, 2010
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: DANIEL D. CARSON, MARY C. FARACH-CARSON, MARGARET FRENCH, RONALD GOMES
  • Delivery system for heparin-binding growth factors
    Patent number: 7671018
    Abstract: New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and scaffolds coated with such proteoglycans are disclosed. The proteoglycan of the invention is derived from domain I or perlecan.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: March 2, 2010
    Assignee: University of Delaware
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Margaret French, Ronald Gomes, Rupert Timpl
  • BIOACTIVE PEPTIDE FOR CELL ADHESION
    Publication number: 20090239304
    Abstract: Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.
    Type: Application
    Filed: March 5, 2009
    Publication date: September 24, 2009
    Applicant: University of Delaware
    Inventors: Mary C. Farach-Carson, Daniel D. Carson, Jeffrey B. Safran
  • Compositions and methods for repair of tissues
    Publication number: 20090162436
    Abstract: Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and a growth factor, and, optionally, collagen.
    Type: Application
    Filed: June 7, 2007
    Publication date: June 25, 2009
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Weidong (William) Yang
  • Delivery system for heparin-binding growth factors
    Publication number: 20040063619
    Abstract: New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and scaffolds coated with such proteoglycans are disclosed. The proteoglycan of the invention is derived from domain I or perlecan.
    Type: Application
    Filed: August 4, 2003
    Publication date: April 1, 2004
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Margaret French, Ronald Gomes, Rupert Timpl
  • Bioactive peptide for cell adhesion
    Publication number: 20040043450
    Abstract: The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scalffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.
    Type: Application
    Filed: July 7, 2003
    Publication date: March 4, 2004
    Inventors: Mary C Farach-Carson, Daniel D Carson, Jeffrey B Safran