Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to SCHIZOPHRENIA disease and/or their response to a particular drug or drugs.

Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to ADHD disease and/or their response to a particular drug or drugs.

Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to psoriasis disease and/or their response to a particular drug or drugs.

Abstract: The invention concerns a method for calibrating a tool, of the touch probe type, used on a contact type measuring machine, in order to take account of its dynamic geometrical features. Said method enables, in particular, the uncertainties associated with the bending deformation of said touch probe, to be precisely determined.

Abstract: A manual dispenser dispenses a liquid substance by pressure, and automatically closes in the absence of pressure. The dispenser has a push button for controlling an aerosol valve or pump, or a stopper for a receptacle having flexible, compressible walls. The dispenser is characterized in that it comprises a nozzle (3) with an elastically deformable distribution slot (7) which nozzle is integrated by molding into a relatively rigid body (1).

Abstract: The invention concerns a method for calibrating a tool, of the touch probe type, used on a contact type measuring machine, in order to take account of its dynamic geometrical features.

Abstract: The present invention has for its object a watch movement more particularly a wrist watch, a chronograph watch or a pocket watch which comprises a time display formed by a dial and hands and which comprises a tide indicator constituted by a tides disk 16 which is to be seen through a window of the dial 5 and which makes one turn in twenty-four hours. This disk is driven in rotation through the hand display. A moon phases hand 15 is also driven by the hand display, at the speed of one turn in 29.5 days and cooperates simultaneously with the tides disk 16 and with the signs 20 to 23 representing the phases of the moon disposed on the dial 5 around the tides disk 16.

Abstract: A contact sensing probe with a cylindrical housing component (1), with a bearing (4) and a hemispherical element (3), possesses a stylus (13) which displaces the hemispherical element (3) and, with that, the transmission element (2). A measured value converter (14) is provided within the contact sensing probe. The running surfaces (1a, 2a) of the housing component (1) and the transmission element (2) comprise high strength ceramic material with a mean roughness value R.sub.a of .ltoreq.0.8 .mu.m, respectively 32 .mu.in. Rotational security is provided not only for the hemispherical element (3) but also for the transmission element (2).

Abstract: A double faced watch has a movement driving a first gearing actuating a first hands array cooperating with a first dial and a second dial 31 on its opposed face cooperating with a second hands array 32, 33', 43. An automatic winding mass 19 is pivoted concentrically to the two hands arrays by a bail bearing the internal housing of which is fastened on a sleeve giving passage to an axle 7, 7', carrying one hand of the first hands array. This axle 7, 7' is used as a driver for the driving of the second hands array. A time setting stem 55 is axially slidable between two positions, in one of which its rotation sets one of the hands arrays and in the other of which its rotation sets the other hands array. A tilting member 62 (FIG. 6) ensures that the setting stem 55 slides in the opposite direction from a sliding pinion 47 so that the stem 55 and pinion 47 are alternately in driving relation with one or the other of the drive trains of the two hands arrays.

Abstract: A motor actuates a wheel train which drives center hour and minute hands as in an ordinary analog-display watch. Another motor actuates a chronograph train which drives a chronograph sweep seconds-hand, a minute-register hand, and an hour-register hand offset toward 6 o'clock. A lever actuates a column wheel which starts and stops the second motor by means of a control lever integral with a stem. A hammer resets the chronograph gears. An electronic circuit comprises a liquid-crystal display element which displays the hundredths of a second when the chronograph is running or the date when the chronograph is not running.

Abstract: The liquid crystal display cell (21) indicates the date in an aperture situated at 12 o'clock. The hour wheel (31) and the center wheel (29) present coaxial pipes which pass through the dial and bear hour and minute hands. These wheels are driven by a wheel-train (30, 28, 27) actuated by the stepping motor (25) which receives its pulses from the circuit (23) controlled at a frequency of 1 Hz for example by the quartz (48). The 24-hour wheel (33) bears a contact element (46) which, once per revolution, grounds the terminal (47). The pulse which results therefrom is transmitted to a counter incorporated in the circuit (23). This counter controls the decoding circuit which controls the display cell (21). To effect the setting of the date, the stem (35) is brought into its intermediate position (II). The contact element (40) borne by the yoke (38) then grounds the terminal (41), which causes in the circuit (23) the emission of pulses at a frequency of 1 Hz which controls a repeated and rapid change of date.