Abstract: Chlorotoxin derivatives containing amino acid sequence X0X1CMPCXS1XS2XS3DHXS4XS5ARRCX2X3CCGGYGX4CFGYQC LCX5X6X7X8 wherein (i) the N-terminal X0X1 cluster is AM, 0M, or 00; (ii) the solubility XS1XS2XS3XS4XS5 cluster is FTTQT, FTTES, SSSQT, SSSES, FSSQT, FSSES, or FSSQS; (iii) the internal X2X3X4 cluster is DKR, RDK, KDR, IKY, HKW, DRK, LKQ, KKK; and (iv) the C-terminal X5X6X7X8 cluster is N000, R000, NR00, NRG0, NRGY, NRRR, or RRRR; 0 denotes a position where no amino acid is present; the chlorotoxin derivative has a relative human MMP-2 binding that is at least 1.62 times higher than the wild-type chlorotoxin of SEQ ID NO: 1.

Abstract: A method and system are provided for characterizing a portion of biological tissue. A surface of the tissue is illuminated with light having a known wavelength spectrum capable of materially penetrating the tissue. The intensity of the illumination light remitted from the tissue in response to the illumination over a known measurement window is measured over a hyperspectral range of wavelengths for at least two distinguishable polarization components. Based on a model of the response of the tissue and the preceding measurements, data representative of the location and one or more characteristics of an abnormal portion of the tissue are produced. A method is provided to eliminate the masking effect of melanin to obtain accurate estimations of an anomaly.

Abstract: A breathalyzer system for use with a computer consisting of a breathalyzer, computer software and hardware, an interface and method for delaying posts by persons who cannot prove sobriety upon initial posting. The breathalyzer registers the level of sobriety, and the result is sent through an interface to the software. If the alcohol level is below an acceptable threshold, unencumbered access to the social media is granted. If the alcohol level is above an acceptable threshold, access to websites, posting on social media websites, uploading videos, online gambling, or making large purchases is restricted.

Abstract: A disposable tubular end cap for a dermoscope for examining the skin of an animal. The end cap has one end for receiving light from and transmitting light to the dermoscope, a removable calibration target disposed at the other end having optical characteristics similar to a standard skin type, and an identifier disposed on the end cap. The identifier uniquely identifies the end cap and associates it with both data regarding light emitted from the skin of an animal and calibration data derived from the calibration target. Animal tissue may be examined to identify lesions using a plurality of wavelengths and a plurality of polarizations.

Abstract: A breathalyzer system for use with a computer consisting of a breathalyzer, computer software and hardware, an interface and method for delaying posts by persons who cannot prove sobriety upon initial posting. The breathalyzer registers the level of sobriety, and the result is sent through an interface to the software. If the alcohol level is below an acceptable threshold, unencumbered access to the social media is granted. If the alcohol level is above an acceptable threshold, access to websites, posting on social media websites, uploading videos, online gambling, or making large purchases is restricted.

Abstract: A microscopy method and apparatus includes placing a specimen to be observed adjacent to a reflective holographic optical element (RDOE). A beam of light that is at least partially coherent is focused on a region of the specimen. The beam forward propagates through the specimen and is at least partially reflected backward through the specimen. The backward reflected light interferes with the forward propagating light to provide a three dimensional interference pattern that is at least partially within the specimen. A specimen region illuminated by the interference pattern is imaged at an image detector. Computational reconstruction is used to generate a microscopic image in all three spatial dimensions (X,Y,Z), simultaneously with resolution greater than conventional microscopy.