Abstract: A method of determining patient-specific implant parameters for an implant used in a surgical procedure is described. A surgical system receives one or more initial transfer functions and one or more preoperative input factors for a patient and generates a surgical plan comprising one or more patient-specific implant parameters based on the one or more initial transfer functions and the one or more preoperative input factors for the patient. The surgical system further receives one or more intraoperative input factors for the patient and updates the one or more patient-specific implant parameters based on the one or more intraoperative input factors for the patient. An implant for the patient is selected based on the one or more updated patient-specific implant parameters.

Abstract: Devices, systems, and methods for measuring a force applied to a joint during a surgical procedure are disclosed. The device includes an insertion tool, a handle, and one or more force indicators. The insertion tool includes an insertion end and a base end. The one or more force indicators may be attached to the insertion tool and the handle. The insertion end of the device may be inserted into a joint during a surgical procedure and used to apply a force to the joint and/or measure the force using the one or more force indicators when the force is applied.

Abstract: Disclosed herein are viral vector production systems secreting nuclease for degradation of residual nucleic acid during viral vector production and methods of the same. Such a viral vector production system comprises a viral vector production cell comprising nucleic acid sequences encoding: 1) viral vector components; and 2) a nuclease, wherein the nuclease is expressed in the production cell and secreted in cell culture thereby degrading residual nucleic acid during viral vector production. Another such viral vector production system comprises 1) a viral vector production cell comprising nucleic acid sequences encoding viral vector components; and 2) a nuclease helper cell comprising a nucleic acid sequence encoding a nuclease, wherein the nuclease is expressed and secreted in co-culture of the production cell of 1) and the helper cell of 2), thereby degrading residual nucleic acid during viral vector production.

Abstract: Systems and methods for determining a care plan for a patient are disclosed. Data from a one or more databases are received or retrieved and used to determine a preferred care plan used to perform a surgical procedure or otherwise treat a patient. The data may include data pertaining to a patient, a healthcare professional, a healthcare facility, an implant, economic data, simulation data, imaging data, and/or the like. The data may be used to determine a plan that provides a positive outcome and patient satisfaction. The data may be updated over time or in real time to improve or refine the determination of care plans for the current patient or other patients.

Abstract: Methods and systems of augmenting an implant intraoperatively and preparing a cone for revision surgical procedure are disclosed. A system includes a cutting device, a tracking and navigation system and a cutting system in operable communication with the cutting device and the tracking and navigation system. The cutting device includes a communication system, a cutting element, and a plurality of optical trackers. The tracking and navigation system is configured to detect a location of optical trackers. The control system is configured to cause the tracking and navigation system to detect the location of the cutting device, determine a revised shape for an implant cavity, cause the cutting device to cut the implant cavity to the revised shape, select a shape for a cone to be placed in the revised implant cavity, and machine the cone to the selected shape.

Abstract: The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.

Abstract: The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.

Abstract: A reconfigurable bone adjustment device (1, 101, 201) includes a first member (10,110, 210, 1010) configured for attachment to a first bone fragment, a second member (20, 130, 230, 1030) configured for attachment to a second bone fragment and a reconfiguration assembly (2, 102, 401, 501, 601, 701, 801, 901, 1020) configured to move the second member relative to the first member. The reconfiguration assembly includes a drive mechanism (50, 150, 250, 440, 540, 640, 740, 840, 940, 1050) and a threaded rod (70, 170, 245, 470, 570, 670, 770, 870, 970, 1070, 1170) operatively coupled to the drive mechanism so that rotation of the drive mechanism rotates the threaded rod. The reconfiguration assembly operates to reduces stresses, forces, bending moments and/or eccentric moments on a junction and/or by configuring the junction in a manner whereby one of more of the forces, is isolated away from the junction.

Abstract: An intramedullary bone transport nail configured for axial bone segment transport by an externally applied magnetic field includes a nail body defining an internal chamber; locking portions for locking respective ends of the nail body in first and second bone fragments of a long bone, respectively; and a transport carriage assembly that is arranged in an axially movable manner within the internal chamber of the nail body and has an aperture for accommodating a transport bone segment screw for fixing a middle bone segment of the long bone to the bone transport carriage. The nail body defines an elongated longitudinal opening to allow axial motion of the transport bone segment screw as the transport carriage assembly moves axially by rotation of a threaded rod affixed to a magnetic driver. Rotation of the threaded rod is achieved by application of torque to the magnetic driver by a rotating external magnetic field.

Abstract: A cell for producing retroviral vectors comprising nucleic acid sequences encoding: i) gag-pol; ii) env; iii) the RNA genome of the retroviral vector; and iv) optionally rev, or a functional substitute thereof, wherein at least two nucleic acid sequences are located at the same genetic locus; and wherein the at least two nucleic acid sequences are in reverse and/or alternating orientations.

Abstract: A low resistance generator includes a series of stator plates and rotors. Stator plates include the coils wrapped around coil spools. The stator plates and coil spools are made from non-conductive and non-ferromagnetic material. The coils are exposed to the surrounding air and cooled convectively by airflow caused by a rotation of the rotors in the gaps. Rotors house magnets and are disposed within gaps between the stator plates. The rotors are also made of non-conductive and non-ferromagnetic materials. The magnets may be disposed on the rotors to form columns. Two columns of magnets are joined together to form one or more closed magnetic loops, each column being joined by a gauss bridge disposed at first and second end rotors.

Abstract: A low resistance generator includes a series of stator plates and rotors. Stator plates include the coils wrapped around coil spools. The stator plates and coil spools are made from non-conductive and non-ferromagnetic material. The coils are exposed to the surrounding air and cooled convectively by airflow caused by a rotation of the rotors in the gaps. Rotors house magnets and are disposed within gaps between the stator plates. The rotors are also made of non-conductive and non-ferromagnetic materials. The magnets may be disposed on the rotors to form columns. Two columns of magnets are joined together to form one or more closed magnetic loops, each column being joined by a gauss bridge disposed at first and second end rotors.

Abstract: A low resistance generator includes a series of stator plates and rotors. Stator plates include the coils wrapped around coil spools. The stator plates and coil spools are made from non-conductive and non-ferromagnetic material. The coils are exposed to the surrounding air and cooled convectively by airflow caused by a rotation of the rotors in the gaps. Rotors house magnets and are disposed within gaps between the stator plates. The rotors are also made of non-conductive and non-ferromagnetic materials. The magnets may be disposed on the rotors to form columns. Two columns of magnets are joined together to form one or more closed magnetic loops, each column being joined by a gauss bridge disposed at first and second end rotors.

Abstract: The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.

Abstract: An adjustable surgical retractor clamping mechanism for attaching mechanism to an operating table. The mechanism includes an upper jaw, lower jaw, a drive member, an adjustable frame support post and a releasable clamp for adjusting the height of the surgical retracting frame. The upper portion of the lower jaw has a plurality of slots cut into the sidewalls of upper jaw to form at least one flexible finger. The clamp is in close sliding relationship to the upper portion of lower jaw member. The clamp includes a cam lever. Movement of the cam lever to its closed position compresses the clamp causing the flexible fingers to grip the adjustable post locking its longitudinal movement. Rotation of the cam lever to the open position releases the compressive force on the clamp, unlocking the adjustable post allowing the post to be longitudinally adjusted relative to the clamping mechanism.

Abstract: An adjustable surgical retractor system for clamping system to an operating table. The clamping mechanism includes an upper jaw, lower jaw, a drive member, an adjustable frame support post and releasable locking mechanism for adjusting the height of the surgical retracting frame. The releasable locking mechanism can be a mechanism that includes a sleeve in close sliding relationship to the upper portion of lower jaw member. The upper portion of the lower jaw has a plurality of sockets for receipt of a plurality of balls. The sleeve can have a first position which positions an internal shoulder in alignment with the sockets and urges the balls into engagement with circumferential grooves in post member to lock the post at desired height. In a second position, an internal groove in the sleeve can align with the sockets to allow the balls to move partially out of the sockets and out of engagement with the groove in the post so that the post can be longitudinally adjusted relative to the clamping mechanism.

Abstract: An apparatus, system and method including an event notification appliance including first and second light sources configured to indicate an event, including a fire and/or alert.

Abstract: A hazard alarm system includes a hazard alarm notification appliance, and a warning detector which detects a warning alert message from an external source (such as a governmental organization). The hazard alarm system processes the warning alert message and issues an alarm system alert via the notification appliance.

Abstract: An emergency medical collar adapted to be moved between a first more flexible state and a second more rigid state includes a body sized and adapted to be fitted to the neck region of a patient, and a chamber disposed inside of the body. The emergency medical collar also includes a support element disposed inside of the chamber. The emergency medical collar is adapted to allow attachment to the neck region of a patient when the neck of the patient is in a variety of positions, for example, neutral, extended, flexed, or lateral.

Abstract: In accordance with the embodiments of the present invention, an alarm system is provided. The alarm system includes a system controller coupled to at least one initiation device. At least one textual notification device such as for example a signboard is coupled to the system controller. In one embodiment, the textual notification device is a multi-line signboard having an alarm input and a secondary input. The textual notification device is supervised, controlled, and powered integrally with the system controller. In an additional embodiment, an audible generator can be provided that provides an audible message in conjunction with the visual message on the textual notification devices.