Abstract: Generally provided herein are methods, compounds, and compositions described useful for the treatment of light chain amyloidosis and other amyloid protein diseases.

Abstract: The valve system of this invention is for use on an internal combustion engine having a plurality of pistons slidable in respective cylinders each forming a combustion chamber. The engine comprises a block forming the cylinders and having a head or rotary valve housing mounted to the top of the block. In a multiple cylinder in-line engine design, a shaft is suitably supported extending within the housing and is driven via a timing belt from the crankshaft. A plurality of preferably parabolically shaped rotors are fixedly disposed along the length of the shaft at predetermined intervals with each rotor positioned above a cylinder and received by a bushing of the housing. The shaft is preferably spring loaded at one end and supported by bearings at both ends. Each rotor is constructed of a pressed graphite and has an arcuate recess for providing selective communication between either an inlet port or an exhaust port and a passage in the head leading to the combustion chamber.