Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: Methods and systems for generating dynamic voicemail greetings are disclosed. According to an implementation, a voice call made from a caller to a recipient is directed to a voicemail server when the recipient is unreachable. The voicemail server may determine a relationship between the caller and the recipient. The voicemail server may further determine at least one of location data, event data, or time data associated with the recipient. The voicemail server may obtain the real-time location and event data from the recipient's phone and combine it with the saved location and event data to determine the content for the voicemail greeting message. The voicemail server may further select one or more templates based on the relationship between the caller and the recipient and the location and event content and generate a dynamic greeting message to be transmitted to the caller.

Abstract: Various of the disclosed embodiments contemplate systems and methods for assessing structural complexity within an intra-surgical environment. For example, in some embodiments, surface characteristics from three-dimensional models of a patient interior, such as a colon, bronchial tube, esophagus, etc. may be used to infer the surface's level of complexity. Once determined, complexity may inform a number of downstream operations, such as assisting surgical operators to identify complex regions requiring more thorough review, the automated recognition of healthy or unhealthy tissue states, etc. While some embodiments apply to generally cylindrical internal structures, such as a colon or branching pulmonary pathways, etc., other embodiments may be used within other structures, such as inflated laparoscopic regions between organs, joints, etc. Various embodiments also consider graphical and feedback indicia for representing the complexity assessments.

Abstract: An atherectomy system includes a handle having a handle housing, with a drive member extending through the handle housing and operably coupled to an atherectomy burr. A drive mechanism is disposed within the handle housing and is adapted to rotatably engage the drive member. The drive mechanism may include an electric drive motor, a drive gear that is rotatably engaged with the electric drive motor and a driven gear that is coupled with the drive member and is engaged with the drive gear such that rotation of the driven gear causes rotation of the drive member. The drive mechanism may be configured to enable a rotation speed of the atherectomy burr of up to at least about 200,000 revolutions per minute (rpm).

Abstract: Embodiments herein relate to systems and methods for intravascular lesion disruption. In an embodiment, a catheter system for imparting pressure to induce fractures upon a vascular lesion within or adjacent a blood vessel wall is included. The system includes a catheter configured to advance to a vascular lesion, the catheter including an elongate shaft that defines at least a first orifice for fluid flow; a balloon, coupled to the elongate shaft, that surrounds the first orifice where the balloon can expand from a collapsed configuration suitable for advancing the catheter through a patient's vasculature to a first expanded configuration suitable for anchoring the catheter in position relative to a treatment site; and a propulsion system configured to propel a fluid from the first orifice toward the balloon wall to create an inertial impulse in a vessel wall to transfer momentum to the vascular lesion. Other embodiments are also included herein.

Abstract: A method for matching a vehicle with a user including receiving a user ride request for a vehicle from a plurality of available vehicles from a user, receiving a threshold vehicle risk score preference for the user, receiving a user risk score for the user, receiving a threshold user risk score preference for the plurality of available vehicles, identifying a subset of the plurality of available vehicles having a vehicle risk score at or below the threshold vehicle risk score preference of the user and a threshold user risk score preference at or above the user risk score of the user, and presenting the user with ride options for selecting one of the subset of the plurality of available vehicles of the subset of available vehicles for the user ride request.

Abstract: In various embodiments a computer-implemented method for providing sustainability insights to a user designing an object. The method includes determining a first value of a sustainability metric associated with a design of an object, displaying, via a graphical user interface (GUI), a visual indication of the first value of the sustainability metric, and detecting a change to the design of the object. The method further includes, in response to detecting the change to the design of the object, determining a second value of the sustainability metric and displaying, via the GUI, a visual indication of the second value of the sustainability metric.

Abstract: In various embodiments a computer-implemented method for providing sustainability insights to a user designing an object. The method includes determining a value of a sustainability metric associated with a design of an object; determining a target value for the sustainability metric; determining an amount of progress made towards achieving the target value for the sustainability metric based on the value of the sustainability metric and the target value for the sustainability metric; and displaying, via a graphical user interface (GUI), a visual indication of the amount of progress made towards achieving the target value for the sustainability metric.

Abstract: A method for fabricating a SiC power semiconductor device includes: providing a SiC power semiconductor die; depositing a metallization layer over the power semiconductor die, the metallization layer including a first metal; arranging the power semiconductor die over a die carrier such that the metallization layer faces the die carrier, the die carrier being at least partially covered by a plating that includes Ni; and diffusion soldering the power semiconductor die to the die carrier such that a first intermetallic compound is formed between the power semiconductor die and the plating, the first intermetallic compound including Ni3Sn4.

Abstract: An atherectomy system includes a handle and a drive motor that is adapted to rotate a drive cable extending through the handle and operably coupled to an atherectomy burr. A control system is adapted to regulate operation of the drive motor, including providing the drive motor with a high frequency pulse width modulation (PWM) drive signal in order to operate the drive motor. The control system monitors a motor performance parameter such as motor speed or motor torque, and when the motor performance parameter approaches a limit of a performance range, the control system adds a low frequency PWM signal to the high frequency PWM drive signal, thereby causing the drive motor to produce a tactile signal that signals to the user that the motor performance parameter is approaching the limit of the performance range.

Abstract: A photoacoustic catheter adapted for placement within a blood vessel having a vessel wall includes an elongate shaft, a balloon and a photoacoustic transducer. The elongate shaft can extend from a proximal region to a distal region. The elongate shaft can include a light guide that is configured to be placed in optical communication with a light source. The balloon is coupled to the elongate shaft, and can be configured to expand from a collapsed configuration suitable for advancing the photoacoustic catheter through a patient's vasculature to a first expanded configuration suitable for anchoring the photoacoustic catheter in position relative to a treatment site. The photoacoustic transducer can be disposed on a surface of the balloon and in optical communication with the light guide. The photoacoustic transducer can include a light-absorbing material and a thermal expansion material.

Abstract: Methods, computer program products, and/or systems are provided that perform the following operations: determining a pacing requirement for host requests based on one or more thresholds; setting a pacing delay level based on the one or more thresholds in response to the determination of the pacing requirement; and implementing a memory request flow for a host request based on the pacing requirement and the pacing delay level.

Abstract: A catheter system for imparting pressure to induce fractures at a treatment site within or adjacent a blood vessel wall includes a catheter, a fortified balloon inflation fluid and a first light guide. The catheter includes an elongate shaft and a balloon that is coupled to the elongate shaft. The balloon has a balloon wall and can expand to a first expanded configuration to anchor the catheter in position relative. The fortified balloon inflation fluid can expand the balloon to the first expanded configuration. The fortified balloon inflation fluid includes a base inflation fluid and a fortification component. The fortification component reduces a threshold for inducing plasma formation in the fortified balloon inflation fluid compared to the base inflation fluid. The fortification component can include at least one of carbon and iron. The first light guide is disposed along the elongate shaft and is positioned at least partially within the balloon.

Abstract: Spatiotemporal robotic navigation may include providing a set of robots non-conflicting access to the same shared resources at different times so that the robots may operate without continually accounting for the locations of the other robots and workers operating in the particular site, without continually planning or updating paths after determining an initial path, and without continuously adjusting movements as the robots near one another. The spatiotemporal robotic navigation involves generating spatiotemporal plans. Each plan has a set of objectives that a robot is to execute by different time intervals. Each plan is generated so as to not conflict with the resources being accessed by other robots at time intervals set in the plans of other robots.

Abstract: Embodiments include methods, systems and computer program products for managing a flash memory device. Aspects include monitoring a percentage of memory of the flash memory device that is in a ready to use state. Aspects also include operating the flash memory device in a first operating mode based on a determination that the percentage is greater than a first threshold value. Aspects further include operating the flash memory device in a second operating mode based on a determination that the percentage has fallen below the first threshold value. Aspects include operating the flash memory device in a third operating mode until the percentage exceeds the first threshold value based on a determination that the percentage has fallen below a second threshold value, which is lower than the first threshold value. The erasing of ready to erase memory block stripes is only performed during the third operating mode.

Abstract: A transmission includes a first housing part, a second housing part connected to the first housing part, and bearings accommodated in the first housing part and supporting an input shaft in a rotatable manner. The input shaft projects through a recess that extends through the second housing part, and a cover part is connected to the first housing part. The cover part or a flange part inserted into the cover part accommodates a sealing system, which provides sealing with respect to the input shaft. The second housing part has an inlet for lubricating oil, which terminates in an axial bore being open with respect to the side of the first housing part facing the cover part, and in a second annular space. The opening of the axial bore facing the cover part is covered and/or sealed by the cover part, and rolling elements of two bearings at least also restricting and/or surrounding the second annular space together with the first housing part.

Abstract: Various examples are provided related to identification of anthropometric information for fitting of compression garments. In one example, a method of generating compression garment fit information includes acquiring images including a selected body part or body area in need of compression therapy; processing the acquired images along with a library of compression garment fit information; generating a 3D reconstruction of the selected body part/area; deriving anthropometric information for the selected body part/area from the 3D reconstruction; providing a compression value corresponding to a prescribed or intended amount of compression therapy applied to the selected body part/area; and generating compression garment fit information for the selected body part/area.

Abstract: Provided are robots that autonomously detect and correct individualized anomalies resulting from deviations in the sensors and/or actuators of individual robots, and environmental anomalies resulting from deviations in the environment elements that the robots rely on or use in the execution of different tasks. To do so, a robot may receive a task, may determine expected kinematics that include expected activations of a set of sensors and actuators by which the robot executes the task, may activate the set of sensors and actuators according to the expected kinematics, may track the actual kinematics resulting from activating the set of sensors and actuators according to the expected kinematics and continuing the activations until detecting one or more environment elements signaling completion of the task, and may adjust one or more sensors, actuators, or environment elements in response to the actual kinematics deviating from the expected kinematics.

Abstract: A photoacoustic catheter adapted for placement within a blood vessel having a vessel wall includes an elongate shaft, a balloon and a photoacoustic transducer. The elongate shaft can extend from a proximal region to a distal region. The elongate shaft can include a light guide that is configured to be placed in optical communication with a light source. The balloon is coupled to the elongate shaft, and can be configured to expand from a collapsed configuration suitable for advancing the photoacoustic catheter through a patient's vasculature to a first expanded configuration suitable for anchoring the photoacoustic catheter in position relative to a treatment site. The photoacoustic transducer can be disposed on a surface of the balloon and in optical communication with the light guide. The photoacoustic transducer can include a light-absorbing material and a thermal expansion material.

Abstract: The present disclosure provides apparatus and methods to both infer stent expansion (vessel expansion or compliance) and probability of procedural success (vessel patency) from pretreatment diagnostic imaging at the point-of-care and also train an inference model to generate such an inference, thus allowing a physician to choose with greater certainty an optimal treatment tool and treatment protocol for treating a vessel of a patient.