Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: An adjustable harvest valve assembly for a bioreactor system which offers all of the benefits of a harvest port, while allowing cell-free liquid to be collected at various liquid heights and multiple times throughout the run.

Abstract: An aseptic sampling system includes substantially sealed sampling lines connecting one or more sample container to a vessel containing the fluid to be sampled. A flow control system includes valves and/or clamps placed strategically along the sampling lines and filtered vent lines are provided at strategic locations relative to a reversible fluid pump in communication with the sampling lines. The clamps are selectively actuated, the vent lines are selectively opened or closed, and the pump is operated in a forward or reverse direction to permit a volume of sample fluid to be drawn from the vessel and into a sample container and to permit fluid to be purged from the sampling lines either into the sample container or back into the vessel. Thus, sampling and purging can be accomplished without opening the system to potentially contaminating agents and without wasting or having to properly dispose the fluid.

Abstract: An aseptic sampling system includes substantially sealed sampling lines connecting one or more sample container to a vessel containing the fluid to be sampled. A flow control system includes valves and/or clamps placed strategically along the sampling lines and filtered vent lines are provided at strategic locations relative to a reversible fluid pump in communication with the sampling lines. The clamps are selectively actuated, the vent lines are selectively opened or closed, and the pump is operated in a forward or reverse direction to permit a volume of sample fluid to be drawn from the vessel and into a sample container and to permit fluid to be purged from the sampling lines either into the sample container or back into the vessel. Thus, sampling and purging can be accomplished without opening the system to potentially contaminating agents and without wasting or having to properly dispose the fluid.

Abstract: The present invention relates to methods and compositions for adenovirus mediated production of a polypeptide of interest in replication non-permissive cells. The invention also relates to compositions resulting from the methods and uses according to the invention.

Abstract: A display system with a matrix type flat panel, for example a liquid crystal panel, has addressing circuits to obtain a television type interlaced image. These circuits are divided into several blocks, both for the addressing of even-numbered and odd-numbered columns and for the addressing of even-numbered and odd-numbered lines, in order to obtain a high-definition image. The graphic processor means used to prepare the video signals to be displayed comprise two sub-groups, one for each of the odd or even image. The two subgroups are respectively associated with two different data measuring devices giving the same essential information, to allow at least one display to be maintained even if one device malfunctions, each of them having at least one symbol generator associated with an image memory to produce a protected display of essential data for use.