Patents by Inventor Daniel Griffith Anderson
Daniel Griffith Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150203439Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: January 16, 2015Publication date: July 23, 2015Inventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher G. Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel Griffith Anderson
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Patent number: 8986988Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.Type: GrantFiled: September 29, 2008Date of Patent: March 24, 2015Assignee: Massachusetts Institute of TechnologyInventors: Rohit Nandkumar Karnik, Seungpyo Hong, Ying Mei, Daniel Griffith Anderson, Jeffrey Michael Karp, Robert S. Langer, Suman Bose
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Patent number: 8969353Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: GrantFiled: November 6, 2009Date of Patent: March 3, 2015Assignee: Massachusetts Institute of TechnologyInventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher G. Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel Griffith Anderson
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Publication number: 20140329884Abstract: The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.Type: ApplicationFiled: May 1, 2014Publication date: November 6, 2014Inventors: Yizhou Dong, Akinleye C. Alabi, Hao Yin, Joseph R. Dorkin, Delai Chen, Robert S. Langer, Daniel Griffith Anderson, Ahmed A. Eltoukhy
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Publication number: 20140322309Abstract: ?-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these ?-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive ?-aminoamidine polymers and polynucleotides can be prepared. The inventive ?-aminoamidine polymers may also be used in preparing microparticles for drug delivery.Type: ApplicationFiled: December 15, 2012Publication date: October 30, 2014Applicant: Massachusetts Institute of TechnoloInventors: Arturo Jose Vegas, Kathryn Ann Whitehead, Daniel Griffith Anderson, Robert S. Langer, Joseph R. Dorkin
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Publication number: 20140314826Abstract: The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C?CR?—C(?O)—O—]nR??(I) [H2C?CR?—C(?O)—NH—]nR??(II) wherein n is 1, 2 or 3, R? is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.Type: ApplicationFiled: May 4, 2012Publication date: October 23, 2014Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE UNIVERSITY OF NOTTINGHAMInventors: Paul Williams, Morgan Russell Alexander, Martyn Christopher Davies, Robert Langer, Daniel Griffith Anderson
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Publication number: 20140256885Abstract: Hair treatment compositions are disclosed comprising a ?-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.Type: ApplicationFiled: March 25, 2014Publication date: September 11, 2014Applicant: Living Proof, Inc.Inventors: David Thomas Puerta, Susan Alice Thiell, Ronald P. McLaughlin, Daniel Griffith Anderson
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Patent number: 8808681Abstract: Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use.Type: GrantFiled: June 5, 2007Date of Patent: August 19, 2014Assignee: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Jason Alan Burdick, Robert S. Langer
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Publication number: 20140161830Abstract: Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.Type: ApplicationFiled: November 25, 2013Publication date: June 12, 2014Applicant: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Kathryn Ann Whitehead, Joseph R. Dorkin, Arturo Jose Vegas, Yunlong Zhang
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Patent number: 8748551Abstract: Hair treatment compositions are disclosed comprising a ?-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.Type: GrantFiled: December 20, 2012Date of Patent: June 10, 2014Assignee: Living Proof, Inc.Inventors: David Thomas Puerta, Susan Alice Thiell, Ronald P. McLaughlin, Daniel Griffith Anderson
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Publication number: 20140105960Abstract: Provided herein are hydrogels and hydrogel-forming compositions that are useful for, among others, tissue regeneration in vivo. Methods for generating such hydrogels, for example, from such hydrogel-forming compositions are also provided herein. Therapeutic methods employing hydrogels and hydrogel-forming composition, for example, for restoration of tissue perfusion in the context of acute ischemia, are also provided. The disclosure also describes kits comprising components useful for generating hydrogels as described herein.Type: ApplicationFiled: October 9, 2013Publication date: April 17, 2014Applicants: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: JANETA ZOLDAN, Robert S. Langer, Daniel S. Kohane, Daniel Griffith Anderson, Akihiko Kusanagi, Hila Epstein-Barash, Beata Chertok
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Publication number: 20140094399Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: September 17, 2013Publication date: April 3, 2014Applicant: Massachusetts Institute of TechnologyInventors: Robert S. Langer, David M. Lynn, David A. Putnam, Mansoor M. Amiji, Daniel Griffith Anderson
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Publication number: 20130344022Abstract: The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.Type: ApplicationFiled: August 26, 2013Publication date: December 26, 2013Applicant: Living Proof, Inc.Inventors: Daniel Griffith Anderson, Amir Nashat, Mitchell John DeRosa, David Thomas Puerta, Ronald P. McLaughlin, Bryan Scott Akcasu, Susan Alice Thiell, Richard Matthew Ramirez
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Publication number: 20130336913Abstract: The present invention provides compositions, kits and methods for treating scalp hair. The compositions include fluorinated (but not perfluorinated), non-polymeric compounds in a suitable excipient to provide beneficial effects on hair.Type: ApplicationFiled: August 23, 2013Publication date: December 19, 2013Applicant: Living Proof, Inc.Inventors: Daniel Griffith Anderson, Amir Nashat, Mitchell John DeRosa, David Thomas Puerta, Ronald P. McLaughlin, Bryan Scott Akcasu, Susan Alice Thiell, Richard Matthew Ramirez
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Publication number: 20130302401Abstract: A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation.Type: ApplicationFiled: August 26, 2011Publication date: November 14, 2013Applicant: Massachusetts Institute of TechnologyInventors: Minglin Ma, Wendy F. Liu, Robert S. Langer, Daniel Griffith Anderson
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Patent number: 8562966Abstract: Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.Type: GrantFiled: December 6, 2011Date of Patent: October 22, 2013Assignee: Massachusetts Institute of TechnologyInventors: Gregory T. Zugates, Andreas Zumbuehl, Robert S. Langer, Daniel Griffith Anderson
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Patent number: 8557223Abstract: The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.Type: GrantFiled: July 22, 2010Date of Patent: October 15, 2013Assignee: Living Proof, Inc.Inventors: Daniel Griffith Anderson, Amir Nashat, Mitchell John DeRosa, David Thomas Puerta, Ronald P. McLaughlin, Bryan Scott Akcasu, Susan Alice Williams, Richard Matthew Ramirez
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Patent number: 8551463Abstract: The present invention provides compositions, kits and methods for treating scalp hair. The compositions include fluorinated (but not perfluorinated), non-polymeric compounds in a suitable excipient to provide beneficial effects on hair.Type: GrantFiled: June 9, 2010Date of Patent: October 8, 2013Assignee: Living Proof, Inc.Inventors: Daniel Griffith Anderson, Amir Nashat, Mitchell John DeRosa, David Thomas Puerta, Ronald P. McLaughlin, Bryan Scott Akcasu, Susan Alice Williams, Richard Matthew Ramirez
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Patent number: 8545818Abstract: The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.Type: GrantFiled: June 7, 2012Date of Patent: October 1, 2013Assignee: Living Proof, Inc.Inventors: Daniel Griffith Anderson, Amir Nashat, Mitchell John DeRosa, David Thomas Puerta, Ronald P. McLaughlin, Bryan Scott Akcasu, Susan Alice Williams, Richard Matthew Ramirez
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Publication number: 20130196948Abstract: Described herein are inventive compositions and methods relating to polymer conjugates and, in particular, to polymer conjugates having pendant side groups comprising ring moieties. In one aspect, embodiments are generally related to compositions that mimic naturally-occurring polyphenol compounds. The compositions comprise, in some embodiments, a polymer backbone having a plurality of hydroxyaromatic pendant side groups or derivatives thereof. For example, in some cases, a pendant side group may be a phenol or a substituted derivative thereof. In some cases, the pendant side group may be an oxidized hydroxyaromatic group, such as a quinone. In some embodiments, self-assembled structures comprising one or more of the polymer conjugates are provided. For example, the polymer conjugates may be combined with a complexing agent to form a particle. In some cases, a polymer conjugate may form a hydrogel.Type: ApplicationFiled: June 23, 2011Publication date: August 1, 2013Applicant: MASSACHUSETTS INSITUTE OF TECHNOLOGYInventors: Omar Fisher, Christopher G. Levins, Robert S. Langer, Daniel Griffith Anderson