Patents by Inventor Daniel H. Kim

Daniel H. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long noncoding RNAS and cell reprogramming and differentiation
    Patent number: 9441224
    Abstract: Long noncoding RNAs (lncRNAs) are identified that enhance pluripotency reprogramming of somatic cells as well as differentiation of pluripotent cells. Induced pluripotent stem (iPS) cell generation from somatic cells leads to the upregulation and downregulation of identified lncRNAs. The modulation of these lncRNAs are capable of enhancing pluripotency of somatic cells as well as enhancing differentiation of a pluripotent cell.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: September 13, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Daniel H. Kim, Barbara J. Wold
  • METHODS FOR STIMULATING A DORSAL ROOT GANGLION
    Publication number: 20160250468
    Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
    Type: Application
    Filed: December 4, 2015
    Publication date: September 1, 2016
    Inventors: Daniel H. KIM, Mir A. IMRAN
  • NEUROSTIMULATION METHODS AND SYSTEMS
    Publication number: 20160250469
    Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
    Type: Application
    Filed: December 4, 2015
    Publication date: September 1, 2016
    Inventors: Daniel H. KIM, Mir A. IMRAN, Jeffery M. KRAMER
  • INTERSPINOUS SPACER
    Publication number: 20160242822
    Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal caming surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the caming surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.
    Type: Application
    Filed: October 19, 2015
    Publication date: August 25, 2016
    Inventors: Moti Altarac, Shawn Tebbe, Joey Camia Reglos, Yang Cheng, Murali P. Kadaba, Daniel H. Kim
  • Prosthetic intervertebral discs
    Publication number: 20160242926
    Abstract: A prosthetic intervertebral disc and methods for using the same are provided. The subject prosthetic discs are characterized by including top and bottom endplates separated by a fibrous compressible element that includes an annular region and a nuclear region. The two plates are held together at least one fiber wound around at least one region of the top endplate and at least one region of the bottom endplate. The subject discs may he employed with separate vertebral body fixation elements, or they may include integrated vertebral body fixation elements. Also provided are kits and systems that include the subject prosthetic discs.
    Type: Application
    Filed: April 27, 2016
    Publication date: August 25, 2016
    Applicant: Spinal Kinetics, Inc.
    Inventors: Daniel H. Kim, Sung Kyu Ha, Kungwoo Lee, Frank W. Frank
  • Spacer insertion instrument
    Patent number: 9393055
    Abstract: A percutaneous and minimally invasive instrument for inserting an interspinous process spacer into a patient is disclosed. The insertion instrument includes a first assembly connected to a handle assembly. The first assembly includes an inner shaft located inside an outer shaft and configured for relative translational motion with respect to the outer shaft. The relative translational motion causes one of the outer or inner shafts to move with respect to the other and thereby deflect at least one prong formed on one of the inner or outer shafts wherein such deflection causes engagement with a juxtapositioned interspinous spacer. The instrument further includes a driving tool configured for removable insertion into a proximal end of a passageway of the instrument.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: July 19, 2016
    Assignee: VertiFlex, Inc.
    Inventors: Moti Altarac, Shawn Tebbe, Daniel H. Kim
  • Prosthetic intervertebral discs
    Patent number: 9364336
    Abstract: A prosthetic intervertebral disc and methods for using the same are provided. The subject prosthetic discs are characterized by including top and bottom endplates separated by a fibrous compressible element that includes an annular region and a nuclear region. The two plates are held together at least one fiber wound around at least one region of the top endplate and at least one region of the bottom endplate. The subject discs may be employed with separate vertebral body fixation elements, or they may include integrated vertebral body fixation elements. Also provided are kits and systems that include the subject prosthetic discs.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: June 14, 2016
    Assignee: SPINAL KINETICS INC.
    Inventors: Daniel H. Kim, Kunwoo Lee, Curtis W. Frank, Sung Kyu Ha
  • Prosthetic intervertebral discs having end plates and an annular capsule
    Patent number: 9364337
    Abstract: Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: June 14, 2016
    Assignee: SPINAL KINETICS, INC.
    Inventors: Daniel H. Kim, Thomas A. Afzal, Michael L. Reo, Uriel Hiram Chee, In Haeng Cho, Kunwoo Lee, Curtis W. Frank, Sung Kyu Ha
  • MINIMALLY INVASIVE TOOLING FOR DELIVERY OF INTERSPINOUS SPACER
    Publication number: 20160135853
    Abstract: A plurality of individual tools is provided where each tool is uniquely configured to perform a step or a portion of a step in a novel procedure associated with the implantation of a stabilizing device (e.g., an interspinous spacer) for stabilizing at least one spinal motion segment. The tools are usable individually, or more preferably as a tooling system in which the tools are collectively employed to implant an interspinous spacer, generally in a minimally invasive manner. For example, each of the tools is arranged with coordinated markings and/or other features to ensure consistent depths of insertion, proper orientation of the tools with respect to each other or an anatomical feature of the patient, and precise delivery of the spacer to maintain safe positioning throughout the implantation procedure.
    Type: Application
    Filed: October 9, 2015
    Publication date: May 19, 2016
    Inventors: Moti Altarac, Robert Gutierrez, Shawn Tebbe, Daniel H. Kim, J. Christopher Flaherty
  • Systems and methods for posterior dynamic stabilization of the spine
    Patent number: 9314279
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member. The methods involve the implantation of one or more devices or expandable spacers.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: April 19, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Daniel H. Kim
  • SELECTIVE STIMULATION TO MODULATE THE SYMPATHETIC NERVOUS SYSTEM
    Publication number: 20160082258
    Abstract: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
    Type: Application
    Filed: November 30, 2015
    Publication date: March 24, 2016
    Inventors: Jeffery M. KRAMER, Daniel H. KIM, Mir A. IMRAN
  • Systems and methods for posterior dynamic stabilization of the spine
    Patent number: 9283005
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: March 15, 2016
    Assignee: VertiFlex, Inc.
    Inventors: Shawn Tebbe, Moti Altarac, Daniel H. Kim
  • SYSTEMS AND METHODS FOR POSTERIOR DYNAMIC STABILIZATION OF THE SPINE
    Publication number: 20160066963
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.
    Type: Application
    Filed: September 4, 2015
    Publication date: March 10, 2016
    Inventor: Daniel H. Kim
  • SYSTEMS AND METHODS FOR POSTERIOR DYNAMIC STABILIZATION OF THE SPINE
    Publication number: 20160030092
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.
    Type: Application
    Filed: April 22, 2015
    Publication date: February 4, 2016
    Inventors: Moti Altarac, Shawn Tebbe, Daniel H. Kim, J. Christopher Flaherty
  • SYSTEMS AND METHODS FOR STABILIZING THE MOTION OR ADJUSTING THE POSITION OF THE SPINE
    Publication number: 20150374415
    Abstract: The present invention provides systems and methods for stabilizing or adjusting the position of at least one spinal motion segment.
    Type: Application
    Filed: April 1, 2015
    Publication date: December 31, 2015
    Inventor: Daniel H. Kim
  • Systems and methods for posterior dynamic stabilization of the spine
    Patent number: 9211146
    Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member or an expansion medium for injection within or for filling the interior of the expandable member via the port. The methods involve the implantation of one or more devices or expandable spacers.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: December 15, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Daniel H. Kim
  • Neurostimulation methods and systems
    Patent number: 9205261
    Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: December 8, 2015
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Spinal Modulation, Inc.
    Inventors: Daniel H. Kim, Mir A. Imran, Jeffery M. Kramer
  • Neurostimulation system
    Patent number: 9205259
    Abstract: Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: December 8, 2015
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Spinal Modulation, Inc.
    Inventors: Daniel H. Kim, Mir A. Imran
  • Methods for stimulating a dorsal root ganglion
    Patent number: 9205260
    Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: December 8, 2015
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Spinal Modulation, Inc.
    Inventors: Daniel H. Kim, Mir A. Imran
  • Interspinous spacer
    Patent number: 9161783
    Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal earning surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the earning surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 20, 2015
    Assignee: VertiFlex, Inc.
    Inventors: Moti Altarac, Shawn Tebbe, Joey Camia Reglos, Yang Cheng, Murali P. Kadaba, Daniel H. Kim